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About the Cover
Cover: This ultrastructural image shows 'dystrophic neurites', a characteristic feature of the pathology in the Alzheimer disease (AD) brain. These structures, which are grossly swollen portions of an axon or sometimes a dendrite, are filled predominantly with autophagic vacuoles such as autophagosomes and autophagolysosomes, reflecting a pathological impairment in the crucial process of autophagy in AD. Disruption of autophagy has important implications for amyloid accumulation and neuron survival in this disease. See Commentary by Nixon (p.4081-4091).
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