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About the Cover
Cover: A filmstrip depicting brightfield and pseudocolour intracellular Ca2+ levels in a fertilizing mouse egg. Following the addition of sperm a series of Ca2+ spikes (warm colours) are observed in the egg, which trigger its release from a metaphase II arrest. By coupling various cell-cycle proteins to GFP the temporal pattern of their destruction can be followed relative to the Ca2+ signal at fertilization. In so doing, it was found that D-box containing substrates were degraded within minutes of the first Ca2+ spike, but KEN-box containing substrates were degraded 1-2 hours later, when the second polar body was extruded. These observations support a role for both APCcdc20 and APCcdh1 in mouse egg activation. See article by Chang et al. (pp. 6289-6296).
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