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About the Cover
Cover: Taxol-stabilized microtubules were polymerized from rhodamine-labeled tubulin and were bound to the surface of a glass microchamber. Endocytic vesicles isolated from rat liver 5 minutes after intravenous injection of Texas-Red asialoorosomucoid were perfused into the chamber, where they bound to the microtubules. Immunodetection of Rab4 (green) revealed a high degree of colocalization of early endocytic vesicles (red) with this protein, consistent with the hypothesis that Rab4 serves as a molecular switch that activates minus-end kinesin-based motility, facilitating early endocytic vesicle fission and consequent receptor-ligand segregation. See article by E. Bananis et al. (pp. 2749-2761).
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