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About the Cover
Cover: The Toxoplasma gondii microneme protein MIC8 serves as an escorter for the non-membrane adhesin TgMIC3. A confocal microscopy image of double immunofluorescence on intracellular parasites expressing the endogenous TgMIC3 (in green) and transiently tranfected with a vector expressing a lipid-anchored form of MIC8 (MIC8-GPI, in red) is shown. In vacuoles containing a rosette of non-transfected parasites, TgMIC3 is perfectly sorted to the apical micronemes. In sharp contrast, in the transiently transfected parasites, TgMIC3 was rerouted to the plasma membrane by its interaction with MIC8-GPI where they colocalised, giving rise to yellow in the merge picture (kindly documented by Thierry Soldati). See the article by Meissner et al. in this issue (pp. 563-574).
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