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First published online September 15, 2004
doi: 10.1242/10.1242/jcs.01341

Journal of Cell Science 117, 4681-4690 (2004)
Published by The Company of Biologists 2004
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Research Article

Nerve regeneration and wound healing are stimulated and directed by an endogenous electrical field in vivo

Bing Song*, Min Zhao, John Forrester and Colin McCaig*

College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK

* Authors for correspondence (e-mail: b.song{at}abdn.ac.uk; c.mccaig{at}abdn.ac.uk)

Accepted 2 June 2004

Biological roles for naturally occurring, extracellular physiological electric fields have been proposed over the past century. However, in the molecular era, many biologists presume that electric fields have little physiological relevance because there has been no unequivocal demonstration of their importance at the single-cell level in vivo. We have used an in vivo rat corneal model, which generates its own endogenous electric field and show that nerve sprouting, the direction of nerve growth and the rate of epithelial wound healing are controlled coordinately by the wound-induced electric field.

Key words: Nerve regeneration, Wound healing, Cornea, Electric field


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JCS 2004 117: 2001. [Full Text]  



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