The WD protein Rack1 mediates protein kinase C and integrin-dependent cell migration

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Buensuceso, C. S.
	Articles by O'Toole, T. E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Buensuceso, C. S.
	Articles by O'Toole, T. E.

Battaini, F., Pascale, A., Paoletti, R. and Govoni, S (1997). The role of anchoring protein Rack1 in PKC activation in the aging rat brain. Trends Neurosci 20, 410-415.[Medline]

Cary, L. A., Chang, J. F. and Guan, J (1996). Stimulation of cell migration by overexpression of focal adhesion kinase and its association with src and fyn. J. Cell Sci 109, 1787-1794.[Abstract]

Chang, B. Y., Conroy, K. B., Machleder, E. M. and Cartwright, C. A (1998). Rack1, a receptor for activated C kinase and a homolog of thesubunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH3T3 cells. Mol. Cell. Biol 18, 3245-3256.[Abstract/Free Full Text]

Chen, P., Xie, H., Sekar, M., Gupta, K. and Wells, A (1994). Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required but mitogen-activated protein kinase is not sufficient for induced cell movement. J. Cell Biol 127, 847-857.[Abstract/Free Full Text]

Csukai, M., Chen, C.-H., DeMatteis, M. A. and Mochly-Rosen, D (1997). The coatomer protein-COP, a selective binding protein (Rack) for protein kinase C. J. Biol. Chem 272, 29200-29206.[Abstract/Free Full Text]

Derman, M. P., Toker, A. J., Hartwig, H., Spokes, K., Falck, J. R, Chen, C. S., Cantley, L. C. and Cantley, L. G (1997). The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J. Biol. Chem 272, 6465-6470.[Abstract/Free Full Text]

Fincham, V. J. and Frame, M. C (1998). The catalytic activity of Src is dispensible for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J 17, 81-92.[Medline]

Garcia-Higuera, I., Gaitatzes, C., Smith, T. F. and Neer, E. J (1998). Folding a WD repeat propeller. J. Biol. Chem 273, 9041-9049.[Abstract/Free Full Text]

Geijsen, N., Spaargaren, M., Raaijmakers, J. A. M., Lammers, J.-W. J., Koenderman, L. and Coffer, P. J (1999). Association of Rack1 and PKCwith the common -chain of the IL-5/IL-3/GM-CSF receptor. Oncogene 18, 5126-5130.[Medline]

Gilmore, A. P. and Romer, L. H (1996). Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell 7, 1209-1224.[Abstract]

Haller, H., Lindschau, C., Maasch, C., Olthoff, H., Kurscheid, D. and Luft, F. C (1998). Integrin-induced protein kinase Cand C translocation to focal adhesions mediates vascular smooth muscle cell spreading. Circ. Res 82, 157-165.[Abstract/Free Full Text]

Huttenlocher, A., Ginsberg, M. H. and Horwitz, A. F (1996). Modulationof cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J. Cell Biol 134, 1551-1562.[Abstract/Free Full Text]

Huttenlocher, A., Palecek, S. P., Lu, Q., Zhang, W., Mellgren, R. L., Lauffenburger, D. A., Ginsberg, M. H. and Horwitz, A. F (1997). Regulation of cell migration by the calcium-dependent protease calpain. J. Biol. Chem 272, 32719-32722.[Abstract/Free Full Text]

Ilic, D., Furuat, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, J., Fujimoto, J., Okada, M., Yamamoto, T. and Aizawa, S (1995). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544.[Medline]

Klemke, R. L., Cai, S., Giannini, A. L., Gallagher, P. J., deLanerolle, P. and Cheresh, D. A (1997). Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol 137, 481-492.[Abstract/Free Full Text]

Klemke, R. L., Leng, J., Molander, R., Brooks, P. C., Vuori, K. and Cheresh, D. A (1998). Cas/crk coupling serves as a \324molecular switch' for induction of cell migration. J. Cell Biol 140, 961-972.[Abstract/Free Full Text]

Laudanna, C., Mochly-Rosen, D., Liron, T., Constantin, G. and Butcher, E. C (1998). Evidence ofprotein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J. Biol. Chem 273, 30306-30315.[Abstract/Free Full Text]

Lewis, J. M., Cheresh, D. A. and Schwartz, M. A (1996). Protein kinase C regulatesv 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J. Cell Biol 134, 1323-1332.[Abstract/Free Full Text]

Liliental, J. and Chang, D. D (1998). Rack1, a receptor for activated protein kinase C, interacts with integrinsubunit. J. Biol. Chem 273, 2379-2383.[Abstract/Free Full Text]

Miranti, C. K., Ohno, S. and Brugge, J. S (1999). Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of shc. J. Biol. Chem 274, 10571-10581.[Abstract/Free Full Text]

Mochly-Rosen, D. and Gordon, A. S (1998). Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J 12, 35-42.[Abstract/Free Full Text]

Naik, U. P., Patel, P. M. and Parise, L. V (1997). Identification of a novel calcium-binding protein that interacts with the integrinIIbcytoplasmic domain. J. Biol. Chem 272, 4651-4656.[Abstract/Free Full Text]

Neer, E. J., Schmidt, C. J., Nambudripad, R. and Smith, T. F (1994). The ancient regulatory-protein family of WD-repeat proteins. Nature 371, 297-300.[Medline]

Ng, T., Shima, D., Squire, A., Bastiaens, P. I. H., Gschmeissner, S., Humphries, M. J. and Parker, P. J (1999). PKCregulates 1 integrin-dependent cell motility through association and control of integrin traffic. EMBO J 14, 3909-3923.

Nguyen, D. H. D., Catling, A. D., Webb, D. J., Sankovic, M., Walker, L. A., Somlyo A. V., Weber, M. J. and Gonias, S. L (1999). Myosin light chain kinase functions downstream of ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J. Cell Biol 146, 149-164.[Abstract/Free Full Text]

Nobes, C. D. and Hall, A (1995). Rho, rac and cdc42 GTPases regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 81, 53-62.[Medline]

Nobes, C. D. and Hall, A (1999). Rho GTPases control polarity, protusion, and adhesion during cell movement. J. Cell Biol 144, 1235-1244.[Abstract/Free Full Text]

O'Toole, T. E., Loftus, J. C., Du, X., Glass, A. A., Ruggeri, Z. M., Shattil, S. J., Plow, E. F. and Ginsberg, M. H (1990). Affinity modulation of theIIb 3integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regulation 1, 883-893.[Medline]

Panetti, T.S., Wilcox, S. A., Horzempa, C. and McKeown-Longo, P. J (1995). v 5integrin receptor-mediated endocytosis of vitronectin is protein kinase C-dependent. J. Biol. Chem 270, 18593-18597.[Abstract/Free Full Text]

Rietzler, M., Bittner, M., Kolanus, W., Schuster, A. and Holzmann, B (1998). The human WD repeat protein WAIT-1 specifically interacts withthe cytoplasmic tails of7-integrins. J. Biol. Chem 273, 27459-27466.[Abstract/Free Full Text]

Rigot, V., Lehmann, M., Andre, F., Daemi, N., Marvaldi, J. and Luis, J (1998). Integrin ligation and PKC activation are required for migration of colon carcinoma cells. J. Cell Sci 111, 3119-3127.[Abstract]

Rodriguez, M. M., Ron, D., Touhara, K., Chen, C.-H. and Mochly-Rosen, D (1999). Rack1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro. Biochemistry 38, 13787-13794.[Medline]

Rodriguez-Vicana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A. and Downward, J (1997). Role of phosphoinositide-3-OH kinase in cell transformation and control of the actin cytoskeleton by ras. Cell 89, 457-467.[Medline]

Ron, D., Chen, C.-H., Caldwell, J., Jamieson, L., Orr, E. and Mochly-Rosen, D (1994). Cloning of an intracellular receptor for protein kinase C: a homolog of thesubunit of G proteins. Proc. Natl. Acad. Sci. USA 91, 839-843.[Abstract/Free Full Text]

Ron, D. and Mochly-Rosen, D (1994). Agonists and antagonists of protein kinase C function, derived from its binding proteins. J. Biol. Chem 269, 21395-21398.[Abstract/Free Full Text]

Ron, D., Luo, J. and Mochly-Rosen, D (1995). C2 region-derived peptides inhibit translocation and function ofprotein kinase C in vivo. J. Biol. Chem 270, 24180-24187.[Abstract/Free Full Text]

Shattil, S. J., O'Toole T. E., Eigenthaler, M., Thon, V., Williams, M., Babior, B. M. and Ginsberg, M. H (1995). 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin 3subunit. J. Cell Biol 131, 807-816.[Abstract/Free Full Text]

Staudinger, J., Zhou, J., Burgess, R., Elledge, S. J. and Olson, E. N (1995). Pick1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J. Cell Biol 128, 263-271.[Abstract/Free Full Text]

Takaishi, K., Kiluchi, A., Kuroda, S., Kotani, K., Sasaki, T. and Takai, Y (1993). Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol. Cell. Biol 13, 72-79.[Abstract/Free Full Text]

Volkov, Y., Long, A. and Kelleher, D (1998). Inside the crawling T cell: leukocyte function-associated antigen-1 cross-linking is associated with microtubule-directed translocation of protein kinase C isoenzymes(I) and. J. Immunol 161, 6487-6495.[Abstract/Free Full Text]

Vuori, K. and Ruoslahti, E (1993). Activation of protein kinase C precedes5 1integrin-mediated cell spreading on fibronectin. J. Biol. Chem 268, 21459-21462.[Abstract/Free Full Text]

Yarwood, S. J., Steele, M. R., Scotland, G., Houslay, M. D. and Bolger, G. B (1999). The Rack1 signaling scaffold protein selectively interacts with cAMP-specific phosphodiesterase PDE4D5 isoform. J. Biol. Chem 274, 14909-14917.[Abstract/Free Full Text]

Zhang, X. A. and Hemler, M. E (1999). Interaction of the integrin1 cytoplasmic domain with ICAP-1 protein. J. Biol. Chem 274, 11-19.[Abstract/Free Full Text]

Zhang, Z.-H., Johnson, J. A., El-Sherif, N., Mochly-Rosen, D. and Boutjdir, M (1997). C2-region derived peptides of-protein kinase C regulate cardiac calcium channel. Circ. Res 80, 720-729.[Abstract/Free Full Text]

This article has been cited by other articles:

S. Chen, F. Lin, M. E. Shin, F. Wang, L. Shen, and H. E. Hamm
RACK1 Regulates Directional Cell Migration by Acting on G{beta}{gamma} at the Interface with Its Effectors PLC{beta} and PI3K{gamma}
Mol. Biol. Cell, September 1, 2008; 19(9): 3909 - 3922.
[Abstract] [Full Text] [PDF]

P. A. Kiely, G. S. Baillie, M. J. Lynch, M. D. Houslay, and R. O'Connor
Tyrosine 302 in RACK1 Is Essential for Insulin-like Growth Factor-I-mediated Competitive Binding of PP2A and {beta}1 Integrin and for Tumor Cell Proliferation and Migration
J. Biol. Chem., August 22, 2008; 283(34): 22952 - 22961.
[Abstract] [Full Text] [PDF]

O. Valerius, M. Kleinschmidt, N. Rachfall, F. Schulze, S. Lopez Marin, M. Hoppert, K. Streckfuss-Bomeke, C. Fischer, and G. H. Braus
The Saccharomyces Homolog of Mammalian RACK1, Cpc2/Asc1p, Is Required for FLO11-dependent Adhesive Growth and Dimorphism
Mol. Cell. Proteomics, November 1, 2007; 6(11): 1968 - 1979.
[Abstract] [Full Text] [PDF]

S. Kraus, D. Gioeli, T. Vomastek, V. Gordon, and M. J. Weber
Receptor for Activated C Kinase 1 (RACK1) and Src Regulate the Tyrosine Phosphorylation and Function of the Androgen Receptor.
Cancer Res., November 15, 2006; 66(22): 11047 - 11054.
[Abstract] [Full Text] [PDF]

T. Shi, Z.-H. Duan, R. Papay, E. Pluskota, R. J. Gaivin, C. A. de la Motte, E. F. Plow, and D. M. Perez
Novel {alpha}1-Adrenergic Receptor Signaling Pathways: Secreted Factors and Interactions with the Extracellular Matrix
Mol. Pharmacol., July 1, 2006; 70(1): 129 - 142.
[Abstract] [Full Text] [PDF]

P. A. Kiely, D. O'Gorman, K. Luong, D. Ron, and R. O'Connor
Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and {beta}1 Integrin To Promote Cell Migration.
Mol. Cell. Biol., June 1, 2006; 26(11): 4041 - 4051.
[Abstract] [Full Text] [PDF]

W. Zhang, C. S. Zong, U. Hermanto, P. Lopez-Bergami, Z. Ronai, and L.-H. Wang
RACK1 Recruits STAT3 Specifically to Insulin and Insulin-Like Growth Factor 1 Receptors for Activation, Which Is Important for Regulating Anchorage-Independent Growth
Mol. Cell. Biol., January 15, 2006; 26(2): 413 - 424.
[Abstract] [Full Text] [PDF]

M. Mourtada-Maarabouni, L. Kirkham, F. Farzaneh, and G. T. Williams
Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis
J. Leukoc. Biol., August 1, 2005; 78(2): 503 - 514.
[Abstract] [Full Text] [PDF]

P. A. Kiely, M. Leahy, D. O'Gorman, and R. O'Connor
RACK1-mediated Integration of Adhesion and Insulin-like Growth Factor I (IGF-I) Signaling and Cell Migration Are Defective in Cells Expressing an IGF-I Receptor Mutated at Tyrosines 1250 and 1251
J. Biol. Chem., March 4, 2005; 280(9): 7624 - 7633.
[Abstract] [Full Text] [PDF]

C. S. Buensuceso, A. Obergfell, A. Soriani, K. Eto, W. B. Kiosses, E. G. Arias-Salgado, T. Kawakami, and S. J. Shattil
Regulation of Outside-in Signaling in Platelets by Integrin-associated Protein Kinase C{beta}
J. Biol. Chem., January 7, 2005; 280(1): 644 - 653.
[Abstract] [Full Text] [PDF]

R. Arya, V. Kedar, J. R. Hwang, H. McDonough, H.-H. Li, J. Taylor, and C. Patterson
Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy
J. Cell Biol., December 20, 2004; 167(6): 1147 - 1159.
[Abstract] [Full Text] [PDF]

X. Huang and J. W. Walker
Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes
J. Cell Sci., April 15, 2004; 117(10): 1971 - 1978.
[Abstract] [Full Text] [PDF]

S. Guil, N. de La Iglesia, J. Fernandez-Larrea, D. Cifuentes, J. C. Ferrer, J. J. Guinovart, and M. Bach-Elias
Alternative Splicing of the Human Proto-oncogene c-H-ras Renders a New Ras Family Protein That Trafficks to Cytoplasm and Nucleus
Cancer Res., September 1, 2003; 63(17): 5178 - 5187.
[Abstract] [Full Text] [PDF]

E. A. Cox, D. Bennin, A. T. Doan, T. O'Toole, and A. Huttenlocher
RACK1 Regulates Integrin-mediated Adhesion, Protrusion, and Chemotactic Cell Migration via Its Src-binding Site
Mol. Biol. Cell, February 1, 2003; 14(2): 658 - 669.
[Abstract] [Full Text] [PDF]

E. J. Dell, J. Connor, S. Chen, E. G. Stebbins, N. P. Skiba, D. Mochly-Rosen, and H. E. Hamm
The beta gamma Subunit of Heterotrimeric G Proteins Interacts with RACK1 and Two Other WD Repeat Proteins
J. Biol. Chem., December 13, 2002; 277(51): 49888 - 49895.
[Abstract] [Full Text] [PDF]

A. McCahill, J. Warwicker, G. B. Bolger, M. D. Houslay, and S. J. Yarwood
The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms
Mol. Pharmacol., December 1, 2002; 62(6): 1261 - 1273.
[Full Text] [PDF]

A. E. Tcherkasowa, S. Adam-Klages, M.-L. Kruse, K. Wiegmann, S. Mathieu, W. Kolanus, M. Kronke, and D. Adam
Interaction with Factor Associated with Neutral Sphingomyelinase Activation, a WD Motif-Containing Protein, Identifies Receptor for Activated C-Kinase 1 as a Novel Component of the Signaling Pathways of the p55 TNF Receptor
J. Immunol., November 1, 2002; 169(9): 5161 - 5170.
[Abstract] [Full Text] [PDF]

A. Besson, T. L. Wilson, and V. W. Yong
The Anchoring Protein RACK1 Links Protein Kinase Cepsilon to Integrin beta Chains. REQUIREMENT FOR ADHESION AND MOTILITY
J. Biol. Chem., June 7, 2002; 277(24): 22073 - 22084.
[Abstract] [Full Text] [PDF]

U. Hermanto, C. S. Zong, W. Li, and L.-H. Wang
RACK1, an Insulin-Like Growth Factor I (IGF-I) Receptor-Interacting Protein, Modulates IGF-I-Dependent Integrin Signaling and Promotes Cell Spreading and Contact with Extracellular Matrix
Mol. Cell. Biol., April 1, 2002; 22(7): 2345 - 2365.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Buensuceso, C. S.

Articles by O'Toole, T. E.

Search for Related Content

PubMed

PubMed Citation

Articles by Buensuceso, C. S.

Articles by O'Toole, T. E.

				P. A. Kiely, G. S. Baillie, M. J. Lynch, M. D. Houslay, and R. O'Connor Tyrosine 302 in RACK1 Is Essential for Insulin-like Growth Factor-I-mediated Competitive Binding of PP2A and {beta}1 Integrin and for Tumor Cell Proliferation and Migration J. Biol. Chem., August 22, 2008; 283(34): 22952 - 22961. [Abstract] [Full Text] [PDF]

				O. Valerius, M. Kleinschmidt, N. Rachfall, F. Schulze, S. Lopez Marin, M. Hoppert, K. Streckfuss-Bomeke, C. Fischer, and G. H. Braus The Saccharomyces Homolog of Mammalian RACK1, Cpc2/Asc1p, Is Required for FLO11-dependent Adhesive Growth and Dimorphism Mol. Cell. Proteomics, November 1, 2007; 6(11): 1968 - 1979. [Abstract] [Full Text] [PDF]

				S. Kraus, D. Gioeli, T. Vomastek, V. Gordon, and M. J. Weber Receptor for Activated C Kinase 1 (RACK1) and Src Regulate the Tyrosine Phosphorylation and Function of the Androgen Receptor. Cancer Res., November 15, 2006; 66(22): 11047 - 11054. [Abstract] [Full Text] [PDF]

				T. Shi, Z.-H. Duan, R. Papay, E. Pluskota, R. J. Gaivin, C. A. de la Motte, E. F. Plow, and D. M. Perez Novel {alpha}1-Adrenergic Receptor Signaling Pathways: Secreted Factors and Interactions with the Extracellular Matrix Mol. Pharmacol., July 1, 2006; 70(1): 129 - 142. [Abstract] [Full Text] [PDF]

				P. A. Kiely, D. O'Gorman, K. Luong, D. Ron, and R. O'Connor Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and {beta}1 Integrin To Promote Cell Migration. Mol. Cell. Biol., June 1, 2006; 26(11): 4041 - 4051. [Abstract] [Full Text] [PDF]

				W. Zhang, C. S. Zong, U. Hermanto, P. Lopez-Bergami, Z. Ronai, and L.-H. Wang RACK1 Recruits STAT3 Specifically to Insulin and Insulin-Like Growth Factor 1 Receptors for Activation, Which Is Important for Regulating Anchorage-Independent Growth Mol. Cell. Biol., January 15, 2006; 26(2): 413 - 424. [Abstract] [Full Text] [PDF]

				M. Mourtada-Maarabouni, L. Kirkham, F. Farzaneh, and G. T. Williams Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis J. Leukoc. Biol., August 1, 2005; 78(2): 503 - 514. [Abstract] [Full Text] [PDF]

				P. A. Kiely, M. Leahy, D. O'Gorman, and R. O'Connor RACK1-mediated Integration of Adhesion and Insulin-like Growth Factor I (IGF-I) Signaling and Cell Migration Are Defective in Cells Expressing an IGF-I Receptor Mutated at Tyrosines 1250 and 1251 J. Biol. Chem., March 4, 2005; 280(9): 7624 - 7633. [Abstract] [Full Text] [PDF]

				C. S. Buensuceso, A. Obergfell, A. Soriani, K. Eto, W. B. Kiosses, E. G. Arias-Salgado, T. Kawakami, and S. J. Shattil Regulation of Outside-in Signaling in Platelets by Integrin-associated Protein Kinase C{beta} J. Biol. Chem., January 7, 2005; 280(1): 644 - 653. [Abstract] [Full Text] [PDF]

				R. Arya, V. Kedar, J. R. Hwang, H. McDonough, H.-H. Li, J. Taylor, and C. Patterson Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy J. Cell Biol., December 20, 2004; 167(6): 1147 - 1159. [Abstract] [Full Text] [PDF]

				X. Huang and J. W. Walker Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes J. Cell Sci., April 15, 2004; 117(10): 1971 - 1978. [Abstract] [Full Text] [PDF]

				S. Guil, N. de La Iglesia, J. Fernandez-Larrea, D. Cifuentes, J. C. Ferrer, J. J. Guinovart, and M. Bach-Elias Alternative Splicing of the Human Proto-oncogene c-H-ras Renders a New Ras Family Protein That Trafficks to Cytoplasm and Nucleus Cancer Res., September 1, 2003; 63(17): 5178 - 5187. [Abstract] [Full Text] [PDF]

				E. A. Cox, D. Bennin, A. T. Doan, T. O'Toole, and A. Huttenlocher RACK1 Regulates Integrin-mediated Adhesion, Protrusion, and Chemotactic Cell Migration via Its Src-binding Site Mol. Biol. Cell, February 1, 2003; 14(2): 658 - 669. [Abstract] [Full Text] [PDF]

				E. J. Dell, J. Connor, S. Chen, E. G. Stebbins, N. P. Skiba, D. Mochly-Rosen, and H. E. Hamm The beta gamma Subunit of Heterotrimeric G Proteins Interacts with RACK1 and Two Other WD Repeat Proteins J. Biol. Chem., December 13, 2002; 277(51): 49888 - 49895. [Abstract] [Full Text] [PDF]

				A. McCahill, J. Warwicker, G. B. Bolger, M. D. Houslay, and S. J. Yarwood The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms Mol. Pharmacol., December 1, 2002; 62(6): 1261 - 1273. [Full Text] [PDF]

				A. E. Tcherkasowa, S. Adam-Klages, M.-L. Kruse, K. Wiegmann, S. Mathieu, W. Kolanus, M. Kronke, and D. Adam Interaction with Factor Associated with Neutral Sphingomyelinase Activation, a WD Motif-Containing Protein, Identifies Receptor for Activated C-Kinase 1 as a Novel Component of the Signaling Pathways of the p55 TNF Receptor J. Immunol., November 1, 2002; 169(9): 5161 - 5170. [Abstract] [Full Text] [PDF]

				A. Besson, T. L. Wilson, and V. W. Yong The Anchoring Protein RACK1 Links Protein Kinase Cepsilon to Integrin beta Chains. REQUIREMENT FOR ADHESION AND MOTILITY J. Biol. Chem., June 7, 2002; 277(24): 22073 - 22084. [Abstract] [Full Text] [PDF]

				U. Hermanto, C. S. Zong, W. Li, and L.-H. Wang RACK1, an Insulin-Like Growth Factor I (IGF-I) Receptor-Interacting Protein, Modulates IGF-I-Dependent Integrin Signaling and Promotes Cell Spreading and Contact with Extracellular Matrix Mol. Cell. Biol., April 1, 2002; 22(7): 2345 - 2365. [Abstract] [Full Text] [PDF]