Mutant cadherin affects epithelial morphogenesis and invasion, but not transformation

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Aberle, H., Butz, S., Stappert, J., Weissig, H., Kemler, R. and Hoschuetzky, H (1994). Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J. Cell Sci 107, 3665-3663.

Barth, A. I. M., Stewart, D. B. and Nelson, W. J (1999). T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant-catenin. Proc. Natl. Acad. Sci. USA 96, 4947-4952.[Abstract/Free Full Text]

Becker, K.-F., Atkinson, M. J., Reich, U., Becker, I., Nekarda, H., Siewert, J. R. and H\232fler, H (1994). E-cadherin gene mutation provide clues to diffuse type gastric carcinomas. Cancer Res 54, 3845-3852.[Abstract/Free Full Text]

Becker, K.-F., Atkinson, M. J., Reich, U., Huang, H.-H., Nekarda, H.,Siewert, J. R. and H\232fler, H (1993). Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas. Hum. Mol. Genetics 2, 803-804.[Free Full Text]

Behrens, J (1999). Cadherins and catenins: role in signal transduction and tumor progression. Cancer Met. Rev 18, 15-30.[Medline]

Behrens, J., Mareel, M. M., Van Roy, F. M. and Birchmeier, W (1989). Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J. Cell Biol 108, 2435-2447.[Abstract/Free Full Text]

Berx, G., Becker, K. F., H\232fler, H. and van Roy, F (1998). Mutations of the human E-cadherin (CDH-1) gene. Human Mutation 12, 226-237.[Medline]

Berx, G., Cleton-Jansen, A.-M., Nollet, F., de Leeuw, J. F., van de Vijver, M. J., Cornelisse, C. and van Roy, F (1995). E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J 14, 6107-6115.[Medline]

Birchmeier, W. and Behrens, J (1994). Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta 1198, 11-26.[Medline]

Brewer, C (1994). Cytomegalovirus plasmid vectors for permanent lines of polarized epithelial cells. Methods Cell Biol 43, 233-245.

Bringuier, P.-P., Giroldi, L. A., Umbas, R., Shimazui, T. and Schalken, J.A (1999). Mechanisms associated with abnormal E-cadherin immunoreactivity in human bladder tumors. Int. J. Cancer 83, 591-595.[Medline]

Bussemakers, M. J. G., Giroldi, L. A., van Bokhoven, A. and Schalken, J.A (1994). Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines. Biochem. Biophys. Res. Comm 203, 1284-1290.[Medline]

Christofori, G. and Semb, H (1999). The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem. Sci 24, 73-76.[Medline]

Damsky, C. H., Richa, J., Solter, D., Knudsen, K. and Buck, C. A (1983). Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue. Cell 34, 455-466.[Medline]

Daniel, C. W., Strickland, P. and Friedman, Y (1995). Expression and functional role of E-and P-cadherins in mouse mammary ductal morphogenesis and growth. Dev. Biol 169, 511-519.[Medline]

Doki, Y., Shiozaki, H., Tahara, H., Inoue, M., Oka, H., Iihara, K., Kadowaki, T., Takeichi, M. and Mori, T (1993). Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer Res 53, 3421-3426.[Abstract/Free Full Text]

Frixen, U. H., Berhens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., L\232chner, D. and Birchmeier, W (1991). E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol 113, 173-185.[Abstract/Free Full Text]

Gayther, S. A., Gorringe, K. L., Ramus, S. J., Huntsman, D., Roviello, F., Grehan, N., Machado, J. C., Pinto, E., Seruca, R., Halling, K. et al. ( (1998). Identification of germ-line E-cadherin mutations in gastric cancer families of European origin. Cancer Res 58, 4086-4089.[Abstract/Free Full Text]

Gossen, M. and Bujard, H (1992). Tight control of gene expression in mammalian cells by tetracycline-reponsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547-5551.[Abstract/Free Full Text]

Guilford, P., Hopkins, J., Harraway, J., McLeod, M., McLeod, N., Harawira, P., Taite, H., Scoular, R., Miller, A. and Reeve, A (1998). E-cadherin germline mutations in familial gastric cancer. Nature 392, 402-405.[Medline]

Gumbiner, B. and Simons, K (1986). A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like peptide. J. Cell Biol 102, 457-468.[Abstract/Free Full Text]

Hajra, K. M., Ji, X. and Fearon, E. R (1999). Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements. Oncogene 18, 7274-7279.[Medline]

Hall, H. G., Farson, D. A. and Bissell, M. J (1982). Lumen formation by epithelial cell lines in resonse to collagen overlay: a morphogenetic model in culture. Proc. Natl. Acad. Sci. USA 79, 4672-4676.[Abstract/Free Full Text]

Hermiston, M. L. and Gordon, J. I (1995). In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation and regulation of programmed cell death. J. Cell Biol 129, 489-506.[Abstract/Free Full Text]

Hermiston, M. L. and Gordon, J. I (1995). Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270, 1203-1207.[Abstract/Free Full Text]

Huiping, C., Sigurgeirsdottir, J. R., Jonasson, J. G., Eiriksdottir, G., Johannsdottir, J. T., Egilsson, V. and Ingvarsson, S (1999). Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer. Brit. J. Cancer 81, 1103-1110.[Medline]

Hyafil, F., Morello, D., Babinet, C. and Jacob, R (1980). A cell surfaceglycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos. Cell 21, 927-934.[Medline]

Jiang, W. G (1996). E-cadherin and its associated protein catenins, cancer invasion and metastasis. Brit. J. Surg 83, 437-446.[Medline]

Jou, T.-S., Stewart, D. B., Stappert, J., Nelson, W. J. and Marrs, J. A (1995). Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc. Natl. Acad. Sci. USA 92, 5067-5071.[Abstract/Free Full Text]

Keirsebilck, A., Van Hoorde, L., Gao, Y., De Bruyne, G., Bruyneel, E., Vermassen, P., Mareel, M. and van Roy, F (1998). Mechanisms of downregulation of transfected E-cadherin cDNA during formation of invasive tumors in syngeneic mice. Invasion Metastasis 18, 44-56.[Medline]

Lu, Q., Paredes, M., Medina, M., Zhou, J., Cavallo, R., Peifer, M., Orecchio, L. and Kosik, K. S (1999). -catenin, an adhesive junction-associated protein which promotes cell scattering. J. Cell Biol 144, 519-532.[Abstract/Free Full Text]

Mareel, M. M., Behrens, J., Birchmeier, W., De Bruyne, G. K., Vleminckx, K., Hogewus, A., Fiers, W. C. and Van Roy, F. M (1991). Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice. Int. J. Cancer 47, 922-928.[Medline]

Marrs, J. A., Napolitano, E. W., Murphy-Erdosh, C., Mays, R. W., Reichardt, L. F. and Nelson, W. J (1993). Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+-K+-ATPase distributions in polarized epithelia. J. Cell Biol 123, 149-164.[Abstract/Free Full Text]

Marrs, J. A., Andersson-Fisone, C., Jeong, M. C., Cohen-Gould, L., Zurzolo, C., Nabi, I. R., Rodriguez-Boulan, E. and Nelson, W. J (1995). Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules. J. Cell Biol 129, 507-519.[Abstract/Free Full Text]

McAteer, J. A., Evan, A. P. and Gardner, K. D (1987). Morphogenetic clonal growth of kidney epithlial cell line MDCK. Anat. Rec 217, 229-239.[Medline]

McNeill, H., Ozawa, M., Kemler, R. and Nelson, W. J (1990). Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell 62, 309-316.[Medline]

Moll, R., Mitze, M., Frixen, U. H. and Birchmeier, W (1993). Differential loss of E-cadherin expression in infitrating ductal and lobular breast carcinomas. Am. J. Path 143, 1731-1742.[Abstract]

Montesano, R., Matsumoto, K., Nakamura, T. and Orci, L (1991). Identification of a fibroblast-derived epithlial morphogen and hepatocyte growth factor. Cell 67, 901-908.[Medline]

Nagafuchi, S., Shirayoshi, Y., Okazaki, K., Yasuda, K. and Takeichi, M (1987). Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 329, 341-343.[Medline]

Oda, T., Kanai, Y., Oyama, T., Yoshiura, K., Shimoyama, Y., Birchmeier, W., Sugimura, T. and Hirohashi, S (1994). E-cadherin gene mutation in human gastric carcinoma cell lines. Proc. Natl. Acad. Sci. USA 91, 1858-1862.[Abstract/Free Full Text]

Ojakian, G. K. and Schwimmer, R (1988). The polarized distribution of an apical cell surface glycoprotein is maintained by interactions with the cytopskeleton of Madin-Darby canine kidney cells. J. Cell Biol 107, 2377-2387.[Abstract/Free Full Text]

Ozawa, M., Baribault, H. and Kemler, R (1989). The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 8, 1711-1717.[Medline]

Ozawa, M. and Kemler, R (1998). The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J. Cell Biol 142, 1605-1613.[Abstract/Free Full Text]

Perl, A. K., Wilgnebus, P., Dahl, U., Semb, H. and Christofori, G (1998). A causal role for E-cadherin in the transition form adenoma to carcinoma. Nature 392, 190-193.[Medline]

Pollack, A. L., Barth, A. I. M., Altschuler, Y., Nelson, W. J. and Mostov, K. E (1997). Dynamics of-catenin interactions with APC protein regulate epithelial tubulogenesis. J. Cell Biol 137, 1651-1662.[Abstract/Free Full Text]

Pollack, A. L., Runyan, R. B. and Mostov, K. E (1998). Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis. Dev. Biol 204, 64-79.[Medline]

Reynolds, A. B., Daniel, J., McCrea, P. D., Wheelock, M. J., Wu, J. andZhang, Z (1994). Identification of a new catenin: the tyrosine kinase substrate p120casassociate with E-cadherin complexes. Mol. Cell. Biol 14, 8333-8342.[Abstract/Free Full Text]

Ringwald, M., Schuh, R., Vestweber, D., Eistetter, H., Lottspeich, F., Engel, J., Dolz, R., Jahnig, F., Epplen, J., Mayer, S. et al. ( (1987). The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion. EMBO J 6, 3647-3653.[Medline]

Rodriguez-Boulan, E. and Nelson, W. J (1989). Morphogenesis of the polarized epithelial phenotype. Science 245, 718-725.[Abstract/Free Full Text]

Santos, O. F. P., Moura, L. A., Roasen, E. M. and Nigam, S. K (1993). Modulation of HGF-induced tubulogenesis and branching by multiple phosphorylation mechanisms. Dev. Biol 159, 535-548.[Medline]

Sommers, C. L., Thompson, E. W., Torri, J. A., Kemler, R., Gelmann, E.P. and Byers, S. W (1991). Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities. Cell Growth Diff 2, 365-372.[Abstract]

St Croix, B., Sheehan, C., Rak, J. W., Florenes, V. A., Slingerlnad, J. M. and Kerbel, R. S (1998). E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27KIP1. J. Cell Biol 142, 557-571.[Abstract/Free Full Text]

Stevenson, B. R., Siliciano, J. D., Mooseker, M. S. and Goodenough, D. A (1986). Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol 103, 755-766.[Abstract/Free Full Text]

Stewart, D., Barth, A. I. M. and Nelson, W. J (2000). Differential regulation of endogenous cadherin expression in MDCK cells by cell-cell adhesion and activation of beta-catenin signaling. J. Biol. Chem 275, 20707-20716.[Abstract/Free Full Text]

Takeichi, M (1990). Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem 59, 237-252.[Medline]

Takeichi, M (1993). Cadherins in cancer: implications for invasion and metastasis. Curr. Opin. Cell. Biol 5, 806-811.[Medline]

Troxell, M. L., Chen, Y.-T., Cobb, N., Nelson, W. J. and Marrs, J. A (1999). Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression. Am. J. Physiol 276, 404-418.

Troxell, M. L., Gopalakrishnan, S., McCormack, J., Poteat, B. A., Pennington, J., Garringer, S. M., Schneeberger, E. E., Nelson, W. J. and Marrs, J. A (2000). Inhibiting cadherin function by dominant mutant E-cadherin expression increases the extent of tight junction assembly. J. Cell Sci 113, 985-996.[Abstract]

Vestweber, D. and Kemler, R (1984). Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissue. Exp. Cell Res 152, 169-178.[Medline]

Vleminckx, K., Vakaet Jr., L., Mareel, M., Fiers, W. and Van Roy, F (1991). Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals and invasion suppressor role. Cell 66, 107-119.[Medline]

Vos, C. B. J., Cleton-Jansen, A. M., Berx, G., de Leeuw, W. J. F., ter Haar, N. T., van Roy, F., Cornelisse, C. J., Peterse, J. L. and van de Vijver, M.J (1997). E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis. Brit. J. Cancer 76, 1131-1133.[Medline]

Wang, A. Z., Ojakian, G. K. and Nelson, W. J (1990). Steps in the morphogenesis of a polarized epithelium I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts. J. Cell Sci 95, 137-151.[Abstract/Free Full Text]

Yap, A. S (1998). The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic review. Cancer Invest 16, 252-261.[Medline]

Yap, A. S., Niessen, C. M. and Gumbiner, B. M (1998). The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening and interaction with p120ctn. J. Cell Biol 141, 779-789.[Abstract/Free Full Text]

Yeaman, C., Grindstaff, K. K. and Nelson, W. J (1999). New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol. Rev 79, 73-98.[Abstract/Free Full Text]

Zhu, A. J. and Watt, F. M (1996). Expression of dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. J. Cell Sci 109, 3013-3023.[Abstract]

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				S. Babb-Clendenon, Y.-c. Shen, Q. Liu, K. E. Turner, M. S. Mills, G. W. Cook, C. A. Miller, V. H. Gattone II, K. F. Barald, and J. A. Marrs Cadherin-2 participates in the morphogenesis of the zebrafish inner ear J. Cell Sci., December 15, 2006; 119(24): 5169 - 5177. [Abstract] [Full Text] [PDF]

				J. A. Scott and A. S. Yap Cinderella no longer: {alpha}-catenin steps out of cadherin's shadow J. Cell Sci., November 15, 2006; 119(22): 4599 - 4605. [Abstract] [Full Text] [PDF]

				R. Kroschewski Molecular Mechanisms of Epithelial Polarity: About Shapes, Forces, and Orientation Problems Physiology, April 1, 2004; 19(2): 61 - 66. [Abstract] [Full Text] [PDF]

				K. L. Schmeichel and M. J. Bissell Modeling tissue-specific signaling and organ function in three dimensions J. Cell Sci., June 15, 2003; 116(12): 2377 - 2388. [Abstract] [Full Text] [PDF]

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