spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    


This Article
Right arrow Summary Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bertinato, J.
Right arrow Articles by Hache, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bertinato, J.
Right arrow Articles by Hache, R. J.
Andrews, N. C. and Faller, D. V (1991). A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucl. Acids Res 19, 2499-.[Free Full Text]

Bailey, S. M., Meyne, J., Chen, D. J., Kurimasa, A., Li, G. C., Lehnert, B. E. and Goodwin, E. H (1999). DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc. Nat. Acad. Sci. USA 96, 14899-14904.[Abstract/Free Full Text]

Bakalkin, G., Yakovleva, T., Hurd, Y. L., Nussenzweig, A., Li, G. C. and Terenius, L (1998). Autoantigen Ku in the brain. Developmentally regulated expression and subcellular localization. Neuroreport 9, 2147-2151.[Medline]

Blier, P. R., Griffith, A. J., Craft, J. and Hardin, J. A (1993). Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. J. Biol. Chem 268, 7594-7601.[Abstract/Free Full Text]

Boubnov, N. V., Hall, K. T., Wills, Z., Lee, S. E., He, D. M., Benjamin, D. M., Pulaski, C. R., Band, H., Reeves, W., Hendrickson, E. A. et al. ( (1995). Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen. Proc. Nat. Acad. Sci. USA 92, 890-894.[Abstract/Free Full Text]

Boulton, S. J. and Jackson, S. P (1996). Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucl. Acids Res 24, 4639-4648.[Abstract/Free Full Text]

Cary, R. B., Chen, F., Shen, Z. and Chen, D. J (1998). A central region of Ku80 mediates interaction with Ku70 in vivo. Nucl. Acids Res 26, 974-979.[Abstract/Free Full Text]

Chan, J. Y., Lerman, M. I., Prabhakar, B. S., Isozaki, O., Santisteban, P., Kuppers, R. C., Oates, E. L., Notkins, A. L. and Kohn, L. D (1989). Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen. J. Biol. Chem 264, 3651-3654.[Abstract/Free Full Text]

Conti, E., Uy, M., Leighton, L., Blobel, G. and Kuriyan, J (1998). Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell 94, 193-204.[Medline]

Dalziel, R. G., Mendelson, S. C. and Quinn, J. P (1992). The nuclear autoimmune antigen Ku is also present on the cell surface. Autoimmunity 13, 265-267.[Medline]

Difilippantonio, M. J., Zhu, J., Chen, H. T., Meffre, E., Nussenzweig, M. C., Max, E. E., Ried, T. and Nussenzweig, A (2000). DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404, 510-514.[Medline]

Dingwall, C. and Laskey, R. A (1991). Nuclear targeting sequences\320a consensus? [see comments]. Trends Biochem. Sci 16, 478-481.[Medline]

Dvir, A., Stein, L. Y., Calore, B. L. and Dynan, W. S (1993). Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. J. Biol. Chem 268, 10440-10447.[Abstract/Free Full Text]

Falzon, M., Fewell, J. W. and Kuff, E. L (1993). EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single-to double-strand transitions in DNA. J. Biol. Chem 268, 10546-10552.[Abstract/Free Full Text]

Finnie, N. J., Gottlieb, T. M., Blunt, T., Jeggo, P. A. and Jackson, S. P (1995). DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Nat. Acad. Sci. USA 92, 320-324.[Abstract/Free Full Text]

Ghoshal, K., Li, Z. and Jacob, S. T (1998). Overexpression of the large subunit of the protein Ku suppresses metallothionein-I induction by heavy metals. Proc. Nat. Acad. Sci. USA 95, 10390-10395.[Abstract/Free Full Text]

Giffin, W., Torrance, H., Rodda, D. J., Prefontaine, G. G., Pope, L. and Hache, R. J. G (1996). Sequence-specific DNA binding by ku autoantigen and its effects on transcription. Nature 380, 265-268.[Medline]

Giffin, W., Kwast-Welfeld, J., Rodda, D. J., Prefontaine, G. G., Traykova-Andonova, M., Zhang, Y., Weigel, N. L., Lefebvre, Y. A. and Hache, R. J (1997). Sequence-specific DNA binding and transcription factor phosphorylation by Ku Autoantigen/DNA-dependent protein kinase. Phosphorylation of Ser-527 of the rat glucocorticoid receptor. J. Biol. Chem 272, 5647-5658.[Abstract/Free Full Text]

Giffin, W., Gong, W., Schild-Poulter, C. and Hache, R. J (1999). Ku antigen-DNA conformation determines the activation of DNA-dependent protein kinase and DNA sequence-directed repression of mouse mammary tumor virus transcription. Mol. Cell. Biol 19, 4065-4078.[Abstract/Free Full Text]

Gorlich, D. and Mattaj, I. W (1996). Nucleocytoplasmic transport. Science 271, 1513-1518.[Abstract]

Gottlieb, T. M. and Jackson, S. P (1993). The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142.[Medline]

Gravel, S., Larrivee, M., Labrecque, P. and Wellinger, R. J (1998). YeastKu as a regulator of chromosomal DNA end structure. Science 280, 741-744.[Abstract/Free Full Text]

Gu, Y., Jin, S., Gao, Y., Weaver, D. T. and Alt, F. W (1997). Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc. Nat. Acad. Sci. USA 94, 8076-8081.[Abstract/Free Full Text]

Gu, Y., Sekiguchi, J., Gao, Y., Dikkes, P., Frank, K., Ferguson, D., Hasty, P., Chun, J. and Alt, F. W (2000). Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc. Nat. Acad. Sci. USA 97, 2668-2673.[Abstract/Free Full Text]

Hache, R. J., Tse, R., Reich, T., Savory, J. G. and Lefebvre, Y. A (1999). Nucleocytoplasmic trafficking of steroid-free glucocorticoid receptor. J. Biol. Chem 274, 1432-1439.[Abstract/Free Full Text]

Higashiura, M., Shimizu, Y., Tanimoto, M., Morita, T. and Yagura, T (1992). Immunolocalization of Ku-proteins (p80/p70): localization of p70 to nucleoli and periphery of both interphase nuclei and metaphase chromosomes. Exp. Cell. Res 201, 444-451.[Medline]

Hsu, H. L., Gilley, D., Blackburn, E. H. and Chen, D. J (1999). Ku is associated with the telomere in mammals. Proc. Nat. Acad. Sci. USA 96, 12454-12458.[Abstract/Free Full Text]

Jin, S. and Weaver, D. T (1997). Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. EMBO J 16, 6874-6885.[Medline]

Kalderon, D., Richardson, W. D., Markham, A. F. and Smith, A. E (1984). Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature 311, 33-38.[Medline]

Kohler, M., Speck, C., Christiansen, M., Bischoff, F. R., Prehn, S., Haller, H., Gorlich, D. and Hartmann, E (1999). Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. Mol. Cell. Biol 19, 7782-7791.[Abstract/Free Full Text]

Koike, M., Awaji, T., Kataoka, M., Tsujimoto, G., Kartasova, T., Koike, A. and Shiomi, T (1999). Differential subcellular localization of DNA-dependent protein kinase components Ku and DNA-PKcs during mitosis. J. Cell Sci 112, 4031-4039.[Abstract]

Koike, M., Ikuta, T., Miyasaka, T. and Shiomi, T (1999). Ku80 can translocate to the nucleus independent of the translocation of Ku70 using its own nuclear localization signal. Oncogene 18, 7495-7505.[Medline]

Kuhn, A., Gottlieb, T. M., Jackson, S. P. and Grummt, I (1995). DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I. Genes Dev 9, 193-203.[Abstract/Free Full Text]

Labhart, P (1995). DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I. Proc. Nat. Acad. Sci. USA 92, 2934-2938.[Abstract/Free Full Text]

Lanford, R. E. and Butel, J. S (1984). Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen. Cell 37, 801-813.[Medline]

Lees-Miller, S. P (1996). The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight. Biochem. Cell. Biol 74, 503-512.[Medline]

Li, G. C., Yang, S. H., Kim, D., Nussenzweig, A., Ouyang, H., Wei, J., Burgman, P. and Li, L (1995). Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen. Proc. Nat. Acad. Sci. USA 92, 4512-4516.[Abstract/Free Full Text]

Lieber, M. R., Grawunder, U., Wu, X. and Yaneva, M (1997). Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr. Opin. Genet. Dev 7, 99-104.[Medline]

Mimori, T., Akizuki, M., Yamagata, H., Inada, S., Yoshida, S. and Homma, M (1981). Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. J. Clin. Invest 68, 611-620.

Myung, K., He, D. M., Lee, S. E. and Hendrickson, E. A (1997). KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity. EMBO J 16, 3172-3184.[Medline]

Nemergut, M. E. and Macara, I. G (2000). Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanisms. J. Cell Biol 149, 835-850.[Abstract/Free Full Text]

Nussenzweig, A., Chen, C., da Costa Soares, V., Sanchez, M., Sokol, K., Nussenzweig, M. C. and Li, G. C (1996). Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382, 551-555.[Medline]

Nussenzweig, A., Sokol, K., Burgman, P., Li, L. and Li, G. C (1997). Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development. Proc. Nat. Acad. Sci. USA 94, 13588-13593.[Abstract/Free Full Text]

Ochem, A. E., Skopac, D., Costa, M., Rabilloud, T., Vuillard, L., Simoncsits, A., Giacca, M. and Falaschi, A (1997). Functional properties of the separate subunits of human DNA helicase II/Ku autoantigen. J. Biol. Chem 272, 29919-29926.[Abstract/Free Full Text]

Osipovich, O., Durum, S. K. and Muegge, K (1997). Defining the minimal domain of Ku80 for interaction with Ku70. J. Biol. Chem 272, 27259-27265.[Abstract/Free Full Text]

Pante, N. and Aebi, U (1996). Toward the molecular dissection of protein import into nuclei. Curr. Opin. Cell Biol 8, 397-406.[Medline]

Prabhakar, B. S., Allaway, G. P., Srinivasappa, J. and Notkins, A. L (1990). Cell surface expression of the 70-kD component of Ku, a DNA-binding nuclear autoantigen. J. Clin. Invest 86, 1301-1305.

Rathmell, W. K. and Chu, G (1994). A DNA end-binding factor involved in double-strand break repair and V(D)J recombination. Mol. Cell. Biol 14, 4741-4748.[Abstract/Free Full Text]

Reeves, W. H. and Sthoeger, Z. M (1989). Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen. J. Biol. Chem 264, 5047-5052.[Abstract/Free Full Text]

Robbins, J., Dilworth, S. M., Laskey, R. A. and Dingwall, C (1991). Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64, 615-623.[Medline]

Smider, V., Rathmell, W. K., Lieber, M. R. and Chu, G (1994). Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266, 288-291.[Abstract/Free Full Text]

Taccioli, G. E., Gottlieb, T. M., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A. R., Alt, F. W., Jackson, S. P. and Jeggo, P. A (1994). Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265, 1442-1445.[Abstract/Free Full Text]

Teoh, G., Urashima, M., Greenfield, E. A., Nguyen, K. A., Lee, J. F., Chauhan, D., Ogata, A., Treon, S. P. and Anderson, K. C (1998). The 86-kD subunit of Ku autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells. J. Clin. Invest 101, 1379-1388.[Medline]

Tuteja, N., Tuteja, R., Ochem, A., Taneja, P., Huang, N. W., Simoncsits, A., Susic, S., Rahman, K., Marusic, L., Chen, J. et al. ( (1994). Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. EMBO J 13, 4991-5001.[Medline]

Ullman, K. S., Powers, M. A. and Forbes, D. J (1997). Nuclear export receptors: from importin to exportin. Cell 90, 967-970.[Medline]

Wang, J., Satoh, M., Pierani, A., Schmitt, J., Chou, C. H., Stunnenberg, H. G., Roeder, R. G. and Reeves, W. H (1994). Assembly and DNA binding of recombinant Ku (p70/p80) autoantigen defined by a novel monoclonal antibody specific for p70/p80 heterodimers. J. Cell Sci 107, 3223-3233.[Abstract]

Wang, J., Dong, X., Myung, K., Hendrickson, E. A. and Reeves, W. H (1998). Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding. J. Biol. Chem 273, 842-848.[Abstract/Free Full Text]

Wang, J., Dong, X. and Reeves, W. H (1998). A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen. J. Biol. Chem 273, 31068-31074.[Abstract/Free Full Text]

Welch, K., Franke, J., Kohler, M. and Macara, I. G (1999). RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3. Mol. Cell. Biol 19, 8400-8411.[Abstract/Free Full Text]

Wu, X. and Lieber, M. R (1996). Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Mol. Cell. Biol 16, 5186-5193.[Abstract]

Yaneva, M. and Jhiang, S (1991). Expression of the Ku protein during cell proliferation. Biochim. Biophys. Acta 1090, 181-187.[Medline]

Yang, S. H., Nussenzweig, A., Li, L., Kim, D., Ouyang, H., Burgman, P. and Li, G. C (1996). Modulation of thermal induction of hsp70 expression by Ku autoantigen or its individual subunits. Mol. Cell. Biol 16, 3799-806.[Abstract]

Yu, E., Song, K., Moon, H., Maul, G. G. and Lee, I (1998). Characteristic immunolocalization of Ku protein as nuclear matrix. Hybridoma 17, 413-420.[Medline]




This article has been cited by other articles:


Home page
J BiochemHome page
M. Kato, T. Nonaka, and S. Imajoh-Ohmi
Cleavage at the Carboxyl-Terminus of Ku80 during Apoptosis in Human Jurkat T Cells
J. Biochem., June 1, 2005; 137(6): 685 - 692.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
C. J. Janzen, F. Lander, O. Dreesen, and G. A. M. Cross
Telomere length regulation and transcriptional silencing in KU80-deficient Trypanosoma brucei
Nucleic Acids Res., December 15, 2004; 32(22): 6575 - 6584.
[Abstract] [Full Text] [PDF]


This Article
Right arrow Summary Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bertinato, J.
Right arrow Articles by Hache, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bertinato, J.
Right arrow Articles by Hache, R. J.