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Baker, K. C., Taylor, M. J., Cummings, N. J., Tunon, M. A., Worboys, K. A. and Connerton, I. F (1996). Autocatalytic processing of pro-papaya proteinase IV is prevented by crowding of the active site cleft. Protein Eng 9, 525-529.[Abstract/Free Full Text]

Bates, P. A., Robertson, C. D., Tetley, L. and Coombs, G. H (1992). Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms. Parasitology 105, 193-202.

Boukai, L. K., Costa-Pinto, D., Soares, M. J., McMahon-Pratt, D. and Traub-Cseko, Y. M (2000). Trafficking of cysteine proteinase to Leishmania lysosomes: lack of involvement of glycosylation. Mol. Biochem. Parasitol 107, 321-325.[Medline]

Berti, P. J. and Storer, A. C (1995). Alignment/phylogeny of the papain superfamily of cysteine proteases. J. Mol. Biol 246, 273-283.[Medline]

Brickman, M. J. and Balber, A. E (1994). Transport of a lysosomal membrane glycoprotein from the Golgi to endosomes and lysosomes via the cell surface in African trypanosomes. J. Cell Sci 107, 3191-3200.[Abstract]

Burns, E. H., Marciel, A. M. and Musser, J. M (1997). Structure-function and pathogenesis studies of Streptococcus pyogenes extracellular cysteine protease. Adv. Exp. Med. Biol 418, 589-592.[Medline]

Cazzulo, J. J., Hellman, U., Couso, R. and Parodi, A. J. A (1990). Amino acid and carbohydrate composition of a lysosomal cysteine proteinase from Trypanosoma cruzi \320 absence of phosphorylated mannose residues. Mol. Biochem. Parasitol 38, 41-48.[Medline]

Coulombe, R., Grochulski, P., Sivaraman, J., Menard, R., Mort, J. S. and Cygler, M (1996). Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. EMBO J 15, 5492-5503.[Medline]

Duboise, S. M., Vannier-Santos, M. A., Costa-Pinto, D., Rivas, L., Pan, A. A., Traub-Cseko, Y. M., de Souza, W. and McMahon-Pratt, D (1994). The biosynthesis, processing, and immunolocalization of Leishmania pifanoi amastigote cysteine proteinases. Mol. Biochem. Parasitol 68, 119-132.[Medline]

Eakin, A. E., McGrath, M. E., McKerrow, J. H., Fletterick, R. J. and Craik, C. S (1993). Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi. J. Biol. Chem 268, 6115-6118.[Abstract/Free Full Text]

Engel, J. C., Doyle, P. S., Palmer, J., Hsieh, I., Bainton, D. F. and McKerrow, J. H (1998). Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi. J. Cell Sci 111, 597-606.[Abstract]

Engel, J. C., Torres Garcia, C., Hsieh, I., Doyle, P. S. and McKerrow, J. H (2000). Upregulation of the secretory pathway in cysteine proteinase inhibitor-resistant Trypanosoma cruzi. J. Cell Sci 113, 1345-1354.[Abstract]

Hellman, U., Wernstedt, C. and Cazzulo, J. J (1991). Self-proteolysis of the cysteine proteinase, cruzipain, from Trypanosoma cruzi gives a major fragment corresponding to its carboxy-terminal domain. Mol. Biochem. Parasitol 44, 15-21.[Medline]

Holwerda, B. C., Galvin, N. J., Baranski, T. J. and Rogers, J. C (1990). In vitro processing of aleurain, a barley vacuolar thiol protease. Plant Cell 2, 1091-1106.[Abstract/Free Full Text]

Huete-Perez, J. A., Engel, J. C., Brinen, L. S., Mottram, J. C. and McKerrow, J. H (1999). Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif. J. Biol. Chem 274, 16249-16256.[Abstract/Free Full Text]

Kelly, J. M., Ward, H. M., Miles, M. A. and Kendall, G (1992). A shuttle vector which facilitates the expression of transfected genes in Trypanosoma cruzi and Leishmania. Nucleic Acids Res 20, 3963-3969.[Abstract/Free Full Text]

Kornfeld, S. and Mellman, I (1989). The biogenesis of lysosomes. Ann. Rev. Cell Biol 5, 483-525.

LeBowitz, J. H., Coburn, C. M., McMahon-Pratt, D. and Beverley, S. M (1990). Development of a stable Leishmania expression vector and application to the study of parasite surface-antigen genes. Proc. Natl. Acad. Sci. USA 87, 9736-9740.[Abstract/Free Full Text]

Mach, L., Mort, J. S. and Gl\232ssl, J (1994). Maturation of human procathepsin B. Proenzyme activation and proteolytic processing of the precursor to the mature proteinase, in vitro , are primarily unimolecular processes. J. Biol. Chem 269, 13030-13035.[Abstract/Free Full Text]

Mason, R. W., Gal, S. and Gottesman, M. M (1987). The identification of the major excreted protein (Mep) from a transformed mouse fibroblast cell-line as a catalytically active precursor form of cathepsin L. Biochem. J 248, 449-454.[Medline]

McIntyre, G. and Erickson, A. H (1993). The lysosomal proenzyme receptor that binds procathepsin L to microsomal membranes at pH 5 is a 43KDa integral membrane protein. Proc. Natl. Acad. Sci. USA 90, 10588-10592.[Abstract/Free Full Text]

Menard, R., Carmona, E., Takebe, S., Dufour, E., Plouffe, C., Mason, P. and Mort, J. S (1998). Autocatalytic processing of recombinant human procathepsin L \320 contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro. J. Biol. Chem 273, 4478-4484.[Abstract/Free Full Text]

Mottram, J. C., Frame, M. J., Brooks, D. R., Tetley, L., Hutchison, J. E., Souza, A. E. and Coombs, G. H (1997). The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes which differin their stage-regulation and substrate preferences. J. Biol. Chem 272, 14285-14293.[Abstract/Free Full Text]

Mottram, J. C., North, M. J., Barry, J. D. and Coombs, G. H (1989). A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension. FEBS Lett 258, 211-215.[Medline]

Mottram, J. C., Robertson, C. D., Coombs, G. H. and Barry, J. D (1992). A developmentally regulated cysteine proteinase gene of Leishmania mexicana. Mol. Microbiol 6, 1925-1932.[Medline]

Mottram, J. C., Souza, A. E., Hutchison, J. E., Carter, R., Frame, M. J. and Coombs, G. H (1996). Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. Proc. Natl. Acad. Sci. USA 93, 6008-6013.[Abstract/Free Full Text]

Nagler, D. K., Zhang, R. L., Tam, W., Sulea, T., Purisima, E. O. and Menard, R (1999). Human cathepsin X: A cysteine protease with unique carboxypeptidase activity. Biochemistry 38, 12648-12654.[Medline]

Nomura, T. and Fujisawa, Y (1997). Processing properties of recombinant human procathepsin L. Biochem. Biophys. Res. Commun 230, 143-146.[Medline]

Pupkis, M. F., Tetley, L. and Coombs, G. H (1986). Leishmania mexicana : amastigote hydrolases in unusual lysosomes. Exp. Parasitol 62, 29-39.[Medline]

Robertson, C. D. and Coombs, G. H (1990). Characterization of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana. Mol. Biochem. Parasitol 42, 269-276.[Medline]

Sanderson, S. J., Pollock, K. G., Hilley, J. D., Meldal, M., Hilaire, P. S., Juliano, M. A., Juliano, L., Mottram, J. C. and Coombs, G. H (2000). Expression and characterisation of a recombinant cysteine proteinase of Leishmania mexicana. Biochem. J 347, 383-388.[Medline]

Selzer, P. M., Pingel, S., Hsieh, I., Ugele, B., Chan, V. J., Engel, J. C., Bogyo, M., Russell, D. G., Sakanari, J. A. and McKerrow, J. H (1999). Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. Proc. Natl. Acad. Sci. USA 96, 11015-11022.[Abstract/Free Full Text]

Souza, A. E., Bates, P. A., Coombs, G. H. and Mottram, J. C (1994). Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana. Mol. Biochem. Parasitol 63, 213-220.[Medline]

Vernet, T., Berti, P. J., Demontigny, C., Musil, R., Tessier, D. C., Menard, R., Magny, M. C., Storer, A. C. and Thomas, D. Y (1995). The ionization state of a conserved amino-acid motif within the pro region participates in the regulation of intramolecular processing. J. Biol. Chem 270, 10838-10846.[Abstract/Free Full Text]

Vernet, T., Khouri, H. E., Laflamme, P., Tessier, D. C., Musil, R., Goursalin, B. J., Storer, A. C. and Thomas, D. Y (1991). Processing of the papain precursor \320 purification of the zymogen and characterization of its mechanism of processing. J. Biol. Chem 266, 21451-21457.[Abstract/Free Full Text]

Vernet, T., Tessier, D. C., Richardson, C., Laliberte, F., Khouri, H. E., Bell, A. W., Storer, A. C. and Thomas, D. Y (1990). Secretion of functional papain precursor from insect cells \320 requirement for N-glycosylation of the pro-region. J. Biol. Chem 265, 16661-16666.[Abstract/Free Full Text]

Zhu, Y. and Conner, G. E (1994). Intermolecular association of lysosomal protein precursors during biosynthesis. J. Biol. Chem 269, 3846-3851.[Abstract/Free Full Text]


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