C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease

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				Y. P. Wang, J. Biernat, M. Pickhardt, E. Mandelkow, and E.-M. Mandelkow Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model PNAS, June 12, 2007; 104(24): 10252 - 10257. [Abstract] [Full Text] [PDF]

				S. Zibaee, O. S. Makin, M. Goedert, and L. C. Serpell A simple algorithm locates beta-strands in the amyloid fibril core of {alpha}-synuclein, Abeta, and tau using the amino acid sequence alone Protein Sci., May 1, 2007; 16(5): 906 - 918. [Abstract] [Full Text] [PDF]

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				H. Ding, T. A. Matthews, and G. V. W. Johnson Site-specific Phosphorylation and Caspase Cleavage Differentially Impact Tau-Microtubule Interactions and Tau Aggregation J. Biol. Chem., July 14, 2006; 281(28): 19107 - 19114. [Abstract] [Full Text] [PDF]

				K. Mi, P. J. Dolan, and G. V. W. Johnson The Low Density Lipoprotein Receptor-related Protein 6 Interacts with Glycogen Synthase Kinase 3 and Attenuates Activity J. Biol. Chem., February 24, 2006; 281(8): 4787 - 4794. [Abstract] [Full Text] [PDF]

				K. Bhaskar, S.-H. Yen, and G. Lee Disease-related Modifications in Tau Affect the Interaction between Fyn and Tau J. Biol. Chem., October 21, 2005; 280(42): 35119 - 35125. [Abstract] [Full Text] [PDF]

				M. Pickhardt, Z. Gazova, M. von Bergen, I. Khlistunova, Y. Wang, A. Hascher, E.-M. Mandelkow, J. Biernat, and E. Mandelkow Anthraquinones Inhibit Tau Aggregation and Dissolve Alzheimer's Paired Helical Filaments in Vitro and in Cells J. Biol. Chem., February 4, 2005; 280(5): 3628 - 3635. [Abstract] [Full Text] [PDF]

				K. Papanikolopoulou, G. Schoehn, V. Forge, V. T. Forsyth, C. Riekel, J.-F. Hernandez, R. W. H. Ruigrok, and A. Mitraki Amyloid Fibril Formation from Sequences of a Natural {beta}-Structured Fibrous Protein, the Adenovirus Fiber J. Biol. Chem., January 28, 2005; 280(4): 2481 - 2490. [Abstract] [Full Text] [PDF]

				W. H. Stoothoff, J.-H. Cho, R. P. McDonald, and G. V. W. Johnson FRAT-2 Preferentially Increases Glycogen Synthase Kinase 3{beta}-mediated Phosphorylation of Primed Sites, Which Results in Enhanced Tau Phosphorylation J. Biol. Chem., January 7, 2005; 280(1): 270 - 276. [Abstract] [Full Text] [PDF]

				J.-H. Cho and G. V. W. Johnson Glycogen Synthase Kinase 3{beta} Induces Caspase-cleaved Tau Aggregation in Situ J. Biol. Chem., December 24, 2004; 279(52): 54716 - 54723. [Abstract] [Full Text] [PDF]

				M. Necula and J. Kuret Pseudophosphorylation and Glycation of Tau Protein Enhance but Do Not Trigger Fibrillization in Vitro J. Biol. Chem., November 26, 2004; 279(48): 49694 - 49703. [Abstract] [Full Text] [PDF]

				G. V. W. Johnson and W. H. Stoothoff Tau phosphorylation in neuronal cell function and dysfunction J. Cell Sci., November 15, 2004; 117(24): 5721 - 5729. [Abstract] [Full Text] [PDF]

				P. M. Horowitz, K. R. Patterson, A. L. Guillozet-Bongaarts, M. R. Reynolds, C. A. Carroll, S. T. Weintraub, D. A. Bennett, V. L. Cryns, R. W. Berry, and L. I. Binder Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease J. Neurosci., September 8, 2004; 24(36): 7895 - 7902. [Abstract] [Full Text] [PDF]

				M. Margittai and R. Langen Template-assisted filament growth by parallel stacking of tau PNAS, July 13, 2004; 101(28): 10278 - 10283. [Abstract] [Full Text] [PDF]

				W. J. Goux, L. Kopplin, A. D. Nguyen, K. Leak, M. Rutkofsky, V. D. Shanmuganandam, D. Sharma, H. Inouye, and D. A. Kirschner The Formation of Straight and Twisted Filaments from Short Tau Peptides J. Biol. Chem., June 25, 2004; 279(26): 26868 - 26875. [Abstract] [Full Text] [PDF]

				J. AVILA, J. J. LUCAS, M. PEREZ, and F. HERNANDEZ Role of Tau Protein in Both Physiological and Pathological Conditions Physiol Rev, April 1, 2004; 84(2): 361 - 384. [Abstract] [Full Text] [PDF]

				F. Moreno-Herrero, M. Perez, A. M. Baro, and J. Avila Characterization by Atomic Force Microscopy of Alzheimer Paired Helical Filaments under Physiological Conditions Biophys. J., January 1, 2004; 86(1): 517 - 525. [Abstract] [Full Text] [PDF]

				A. Ferrari, F. Hoerndli, T. Baechi, R. M. Nitsch, and J. Gotz {beta}-Amyloid Induces Paired Helical Filament-like Tau Filaments in Tissue Culture J. Biol. Chem., October 10, 2003; 278(41): 40162 - 40168. [Abstract] [Full Text] [PDF]

				T. C. Gamblin, F. Chen, A. Zambrano, A. Abraha, S. Lagalwar, A. L. Guillozet, M. Lu, Y. Fu, F. Garcia-Sierra, N. LaPointe, et al. Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease PNAS, August 19, 2003; 100(17): 10032 - 10037. [Abstract] [Full Text] [PDF]

				L. Li, M. von Bergen, E.-M. Mandelkow, and E. Mandelkow Structure, Stability, and Aggregation of Paired Helical Filaments from Tau Protein and FTDP-17 Mutants Probed by Tryptophan Scanning Mutagenesis J. Biol. Chem., October 25, 2002; 277(44): 41390 - 41400. [Abstract] [Full Text] [PDF]