Formation of glycine receptor clusters and their accumulation at synapses

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Meier, J.
	Articles by Vannier, C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Meier, J.
	Articles by Vannier, C.

Altschuler, R., Betz, H., Parakkal, M. H., Reeks, K. A. and Wenthold, R. J (1986). Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor. Brain Res 369, 316-320.[Medline]

Baude, A., Sequier, J. M., McKernan, R. M., Olivier, K. R. and Somogyi, P (1992). Differential subcellular distribution of the a6 subunit versus the1 and 2/3 subunits of the GABAA/benzodiazepine receptor complex in granule cells of the cerebellar cortex. Neuroscience 51, 739-748.[Medline]

Baude, A., Nusser, Z., Roberts, J. D., Mulvihill, E., McIlhinney, R. A. and Somogyi, P (1993). The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron 11, 771-787.[Medline]

Bechade, C., Colin, I., Kirsch, J., Betz, H. and Triller, A (1996). Expression of glycine receptorsubunits and gephyrin in cultured spinal neurons. Eur. J. Neurosci 8, 429-435.[Medline]

Betz, H (1991). Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci 14, 458-461.[Medline]

Bormann, J., Rundstrom, N., Betz, H. and Langosch, D (1993). Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo-and hetero-oligomers. EMBO J 12, 3729-3737.[Medline]

Brakeman, P. R., Lanahan, A. A., O'Brien, R., Roche, K., Barnes, C. A., Huganir, R. L. and Worley, P. F (1997). Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386, 284-288.[Medline]

Brewer, G. J., Torricelli, J. R., Evege, E. K. and Price, P. J (1993). Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res 35, 567-576.[Medline]

Chen, C. and Okayama, H (1987). High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol 7, 2745-2752.[Abstract/Free Full Text]

Chirgwin, J. M., Przybyla, A., MacDonald, R. and Rutter, W (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294-5299.[Medline]

Colin, I., Rostaing, P., Augustin, A. and Triller, A (1998). Localization of components of glycinergic synapses during rat spinal cord development. J. Comp. Neurol 398, 359-372.[Medline]

Colin, I., Rostaing, P. and Triller, A (1996). Gephyrin accumulates at specific plasmalemma loci during neuronal maturation in vitro. J. Comp. Neurol 374, 467-479.[Medline]

Craig, A. M., Blackstone, C. D., Huganir, R. L. and Banker, G (1994). Selective clustering of glutamate and-aminobutyric acid receptors opposite terminals releasing the corresponding neurotransmitters. Proc. Natl. Acad. Sci. USA 91, 12373-12377.[Abstract/Free Full Text]

Dong, H., O'Brien, R. J., Fung, E. T., Lanahan, A. A., Worley, P. F. and Huganir, R. L (1997). GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386, 279-284.[Medline]

Evan, G. I., Lewis, G. K., Ramsay, G. and Bishop, J. M (1985). Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol 5, 3610-3616.[Abstract/Free Full Text]

Feng, G., Steinbach, J. H. and Sanes, J. R (1998). Rapsyn clusters neuronal acetylcholine receptors but is inessential for formation of an interneuronal cholinergic synapse. J. Neurosci 18, 4166-4176.[Abstract/Free Full Text]

Feng, G., Tintrup, H., Kirsch, J., Nichol, M. C., Kuhse, J., Betz, H. and Sanes, J. R (1998). Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. Science 282, 1321-1324.[Abstract/Free Full Text]

Flint, A. C., Liu, X. and Kriegstein, A. R (1998). Nonsynaptic glycine receptor activation during early neocortical development. Neuron 20, 43-53.[Medline]

Froehner, S. C (1993). Regulation of ion channel distribution at synapses. Annu. Rev. Neurosci 16, 347-368.[Medline]

Gautam, M., Noakes, P. G., Mudd, J., Nichol, M., Chu, G. C., Sanes, J. R. and Merlie, J. P (1995). Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice. Nature 377, 232-236.[Medline]

Grenningloh, G., Rienitz, A., Schmitt, B., Methfessel, C., Zensen, M., Beyreuther, K., Gundelfinger, E. D. and Betz, H (1987). The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature 328, 215-220.[Medline]

Grenningloh, G., Schmieden, V., Schofield, P. R., Seeburg, P. H., Siddique, T., Mohandas, T. K., Becker, C. M. and Betz, H (1990). Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J 9, 771-776.[Medline]

Grenningloh, G., Pribilla, I., Prior, P., Multhaup, G., Beyreuther, K., Taleb, O. and Betz, H (1990). Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptor. Neuron 4, 963-970.[Medline]

Hamill, O. P., Marty, A., Neher, E., Sakmann, B. and Sigworth, F. J (1981). Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391, 85-100.[Medline]

Hamsikova, E., Zavadova, H., Zaoral, M., Jezek, J., Blaha, K. and Vonka, V (1987). Immunogenicity of a synthetic peptide corresponding to a portion of the heavy chain of H3N2 influenza virus haemagglutinin. J. Gen. Virol 68, 2249-2252.[Abstract/Free Full Text]

Hoch, W., Betz, H. and Becker, C. M (1989). Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptor. Neuron 3, 339-348.

Hoch, W., Betz, H., Schramm, M., Wolters, I. and Becker, C. M (1992). Modulation by NMDA receptor antagonists of glycine receptor isoform expression in cultured spinal cord neurons. Eur. J. Neurosci 4, 389-395.[Medline]

Jones, K. A. and Baughman, R. W (1991). Both NMDA and non-NMDA subtypes of glutamate receptors are concentrated at synapses on cerebral cortical neurons in culture. Neuron 7, 593-603.[Medline]

Kim, E. Cho, K. O. Rothschild, A. and Sheng,M (1996). Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. Neuron 17, 103-113.[Medline]

Kim, J. H. and Huganir,R. L (1999). Organization and regulation of proteins at synapses. Curr. Opin. Cell. Biol 11, 248-254.[Medline]

Kins, S., Kuhse, J., Laube, B., Betz, H. and Kirsch, J (1999). Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK 293 cells. Eur. J. Neurosci 11, 740-744.[Medline]

Kirsch, J. and Betz, H (1995). The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton. J. Neurosci 15, 4148-4156.[Abstract]

Kirsch, J. and Betz, H (1998). Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature 392, 717-720.[Medline]

Kirsch, J., Kuhse, J. and Betz, H (1995). Targeting of glycine receptor subunits to gephyrin-rich domains in transfected human embryonic kidney cells. Mol. Cell. Neurosci 6, 450-461.[Medline]

Kirsch, J., Langosch, D., Prior, P., Littauer, U. Z., Schmitt, B. and Betz, H (1991). The 93-kDa glycine receptor-associated protein binds to tubulin. J. Biol. Chem 266, 22242-22245.[Abstract/Free Full Text]

Kirsch, J., Wolters, I., Triller, A. and Betz, H (1993). Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal cord. Nature 366, 745-748.[Medline]

Kornau, H. C., Schenker, L. T., Kennedy, M. B. and Seeburg, P. H (1995). Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269, 1737-1740.[Abstract/Free Full Text]

Kuhse, J., Kuryatov, A., Maulet, Y., Malosio, M. L., Schmieden, V. and Betz, H (1991). Alternative splicing generates two isoforms of the2 subunit of the inhibitory glycine receptor. FEBS Lett 283, 73-77.[Medline]

Kunkel, T. A (1985). Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82, 488-492.[Abstract/Free Full Text]

Langosch, D., Thomas, L. and Betz, H (1988). Conserved quaternary structure of ligand-gated ion channels: The postsynaptic glycine receptor is a pentamer. Proc. Natl. Acad. Sci. USA 85, 7394-7398.[Abstract/Free Full Text]

Legendre, P (1997). Pharmacological evidence for two types of postsynaptic glycinergic receptors on the Mauthner cell of 52-h-old zebrafish larvae. J. Neurophysiol 77, 2400-2415.[Abstract/Free Full Text]

Levi, S., Chesnoy-Marchais, D., Sieghart, W. and Triller, A (1999). Synaptic control of glycine-, GABAA-receptors and gephyrin expression in cultured motoneurons. J. Neurosci 19, 7434-7449.[Abstract/Free Full Text]

Levi, S., Vannier, C. and Triller, A (1998). Strychnine-sensitive stabilization of postsynaptic glycine receptor clusters. J. Cell Sci 111, 335-345.[Abstract]

Mammen, A. L., Huganir, R. L. and O'Brien, R. J (1997). Redistribution and stabilization of cell surface glutamate receptors during synapse formation. J. Neurosci 17, 7351-7358.[Abstract/Free Full Text]

Meunier-Durmort, C., Ferry, N., Hainque, B., Delattre, J. and Forest, C (1996). Efficient transfer of regulated genes in adipocytes and hepatoma cells by the combination of liposomes and replication-deficient adenovirus. Eur. J. Biochem 237, 660-667.[Medline]

Meunier-Durmort, C., Grimal, H., Sachs, L. M., Demeneix, B. A. and Forest, C (1997). Adenovirus enhancement of polyethylenimine-mediated transfer of regulated genes in differentiated cells. Gene Ther 4, 808-814.[Medline]

Meyer, G., Kirsch, J., Betz, H. and Langosch, D (1995). Identification of a gephyrin binding motif on the glycine receptorsubunit. Neuron 15, 563-572.[Medline]

Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G., Morrison, J. H., O'Dell, T. J. and Grant,S. G (1998). Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396, 433-439.[Medline]

Misek, D. E., Bard, E. and Rodriquez-Boulan, E (1984). Biogenesis of epithelial cell polarity: intracellular sorting and vectorial exocytosis of an apical plasma membrane glycoprotein. Cell 39, 537-546.[Medline]

Nicola, M. A., Becker, C. M. and Triller, A (1992). Development of glycine receptor alpha subunit in cultivated rat spinal neurons: an immunocytochemical study. Neurosci. Lett 138, 173-178.[Medline]

Nusser, Z., Mulvihill, E., Streit, P. and Somogyi, P (1994). Subsynaptic segregation of metabotropic and ionotropic glutamate receptors as revealed by immunogold localization. Neuroscience 61, 421-427.[Medline]

Nusser, Z., Sieghart, W. and Somogyi, P (1998). Segregation of different GABAAreceptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J. Neurosci 18, 1693-1703.[Abstract/Free Full Text]

O'Brien, R. J. Lau, L. F. and Huganir,R. L (1998). Molecular mechanisms of glutamate receptor clustering at excitatory synapses. Curr. Opin. Neurobiol 8, 364-369.[Medline]

Pfeiffer, F., Simler, R., Grenningloh, G. and Betz, H (1984). Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord. Proc. Natl. Acad. Sci. USA 81, 7224-7227.[Abstract/Free Full Text]

Pfeiffer, S., Fuller, S. D. and Simons, K. J (1985). Intracellular sorting and basolateral appearence of the G protein of vesicular stomatitis virus in Madin-Darby canine kidney cells. J. Cell Biol 101, 470-476.[Abstract/Free Full Text]

Pribilla, I., Takagi, T., Langosch, D., Bormann, J. and Betz, H (1992). The atypical M2 segment of thesubunit confers picrotoxinin resistance to inhibitory glycine receptor channels. EMBO J 11, 4305-4311.[Medline]

Prior, P., Schmitt, B., Grenningloh, G., Pribilla, I., Multhaup, G., Beyreuther, K., Maulet, Y., Werner, P., Langosch, D., Kirsch, J. and Betz, H (1992). Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Neuron 8, 1161-1170.[Medline]

Rao, A., Kim, E., Sheng, M. and Craig, A. M (1998). Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture. J. Neurosci 18, 1217-1229.[Abstract/Free Full Text]

Sanes, J. R (1997). Genetic analysis of postsynaptic differentiation at the vertebrate neuromuscular junction. Curr. Opin. Neurobiol 7, 93-100.[Medline]

Schmitt, B., Knaus, P., Becker, C. M. and Betz, H (1987). The M r93,000 polypeptide of the glycine receptor is a peripheral membrane protein. Biochemistry 26, 805-811.[Medline]

Sontheimer, H., Becker, C. M., Pritchett, D. B., Schofield, P. R., Grenningloh, G., Kettenmann, H., Betz, H. and Seeburg, P. H (1989). Functional chloride channels by mammalian cell expression of rat glycine receptor subunit. Neuron 2, 1491-1497.[Medline]

St John, P. A. and Stephens, S. L (1993). Adult-type glycine receptors form clusters on embryonic rat spinal cord neurons developing in vitro. J. Neurosci 13, 2749-2757.[Abstract]

Todd, A. J., Watt, C., Spike, R. C. and Sieghart, W (1996). Colocalization of GABA, glycine and their receptors at synapses in the rat spinal cord. J. Neurosci 16, 974-982.[Abstract/Free Full Text]

Triller, A., Cluzeaud, F., Pfeiffer, F., Betz, H. and Korn, H (1985). Distribution of glycine receptors at central synapses: an immunoelectron microscopy study. J. Cell Biol 101, 683-688.[Abstract/Free Full Text]

Triller, A., Cluzeaud, F. and Korn, H (1987). Gamma-aminobutyric acid-containing terminals can be apposed to glycine receptors at central synapses. J. Cell Biol 104, 947-956.[Abstract/Free Full Text]

Vannier, C. and Triller, A (1997). Biology of the postsynaptic glycine receptor. Int. Rev. Cytol 176, 201-244.[Medline]

Wang, H., Bedford, F. K., Brandon, N. J., Moss, S. J. and Olsen, R. W (1999). GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature 397, 69-72.[Medline]

Yeramian, E., Trautmann, A. and Claverie, P (1986). Acetylcholine receptors are not functionally independent. Biophys. J 50, 253-263.[Abstract/Free Full Text]

This article has been cited by other articles:

M.-V. Ehrensperger, C. Hanus, C. Vannier, A. Triller, and M. Dahan
Multiple Association States between Glycine Receptors and Gephyrin Identified by SPT Analysis
Biophys. J., May 15, 2007; 92(10): 3706 - 3718.
[Abstract] [Full Text] [PDF]

C. Bedet, J. C. Bruusgaard, S. Vergo, L. Groth-Pedersen, S. Eimer, A. Triller, and C. Vannier
Regulation of Gephyrin Assembly and Glycine Receptor Synaptic Stability
J. Biol. Chem., October 6, 2006; 281(40): 30046 - 30056.
[Abstract] [Full Text] [PDF]

C. Hanus, M.-V. Ehrensperger, and A. Triller
Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses.
J. Neurosci., April 26, 2006; 26(17): 4586 - 4595.
[Abstract] [Full Text] [PDF]

D. Gonzalez-Forero and F. J. Alvarez
Differential Postnatal Maturation of GABAA, Glycine Receptor, and Mixed Synaptic Currents in Renshaw Cells and Ventral Spinal Interneurons
J. Neurosci., February 23, 2005; 25(8): 2010 - 2023.
[Abstract] [Full Text] [PDF]

D. Gonzalez-Forero, A. M. Pastor, E. J. Geiman, B. Benitez-Temino, and F. J. Alvarez
Regulation of Gephyrin Cluster Size and Inhibitory Synaptic Currents on Renshaw Cells by Motor Axon Excitatory Inputs
J. Neurosci., January 12, 2005; 25(2): 417 - 429.
[Abstract] [Full Text] [PDF]

M. Eguchi, M. Eguchi-Ishimae, and M. Greaves
The small oligomerization domain of gephyrin converts MLL to an oncogene
Blood, May 15, 2004; 103(10): 3876 - 3882.
[Abstract] [Full Text] [PDF]

J. Meier and R. Grantyn
A Gephyrin-Related Mechanism Restraining Glycine Receptor Anchoring at GABAergic Synapses
J. Neurosci., February 11, 2004; 24(6): 1398 - 1405.
[Abstract] [Full Text] [PDF]

C. Hanus, C. Vannier, and A. Triller
Intracellular Association of Glycine Receptor with Gephyrin Increases Its Plasma Membrane Accumulation Rate
J. Neurosci., February 4, 2004; 24(5): 1119 - 1128.
[Abstract] [Full Text] [PDF]

B. van Zundert, F. J. Alvarez, J. C. Tapia, H. H. Yeh, E. Diaz, and L. G. Aguayo
Developmental-Dependent Action of Microtubule Depolymerization on the Function and Structure of Synaptic Glycine Receptor Clusters in Spinal Neurons
J Neurophysiol, February 1, 2004; 91(2): 1036 - 1049.
[Abstract] [Full Text] [PDF]

P. Legendre, E. Muller, C. I. Badiu, J. Meier, C. Vannier, and A. Triller
Desensitization of Homomeric alpha 1 Glycine Receptor Increases with Receptor Density
Mol. Pharmacol., October 1, 2002; 62(4): 817 - 827.
[Abstract] [Full Text] [PDF]

M. Rosenberg, J. Meier, A. Triller, and C. Vannier
Dynamics of Glycine Receptor Insertion in the Neuronal Plasma Membrane
J. Neurosci., July 15, 2001; 21(14): 5036 - 5044.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Meier, J.

Articles by Vannier, C.

Search for Related Content

PubMed

PubMed Citation

Articles by Meier, J.

Articles by Vannier, C.

				C. Bedet, J. C. Bruusgaard, S. Vergo, L. Groth-Pedersen, S. Eimer, A. Triller, and C. Vannier Regulation of Gephyrin Assembly and Glycine Receptor Synaptic Stability J. Biol. Chem., October 6, 2006; 281(40): 30046 - 30056. [Abstract] [Full Text] [PDF]

				C. Hanus, M.-V. Ehrensperger, and A. Triller Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses. J. Neurosci., April 26, 2006; 26(17): 4586 - 4595. [Abstract] [Full Text] [PDF]

				D. Gonzalez-Forero and F. J. Alvarez Differential Postnatal Maturation of GABAA, Glycine Receptor, and Mixed Synaptic Currents in Renshaw Cells and Ventral Spinal Interneurons J. Neurosci., February 23, 2005; 25(8): 2010 - 2023. [Abstract] [Full Text] [PDF]

				D. Gonzalez-Forero, A. M. Pastor, E. J. Geiman, B. Benitez-Temino, and F. J. Alvarez Regulation of Gephyrin Cluster Size and Inhibitory Synaptic Currents on Renshaw Cells by Motor Axon Excitatory Inputs J. Neurosci., January 12, 2005; 25(2): 417 - 429. [Abstract] [Full Text] [PDF]

				M. Eguchi, M. Eguchi-Ishimae, and M. Greaves The small oligomerization domain of gephyrin converts MLL to an oncogene Blood, May 15, 2004; 103(10): 3876 - 3882. [Abstract] [Full Text] [PDF]

				J. Meier and R. Grantyn A Gephyrin-Related Mechanism Restraining Glycine Receptor Anchoring at GABAergic Synapses J. Neurosci., February 11, 2004; 24(6): 1398 - 1405. [Abstract] [Full Text] [PDF]

				C. Hanus, C. Vannier, and A. Triller Intracellular Association of Glycine Receptor with Gephyrin Increases Its Plasma Membrane Accumulation Rate J. Neurosci., February 4, 2004; 24(5): 1119 - 1128. [Abstract] [Full Text] [PDF]

				B. van Zundert, F. J. Alvarez, J. C. Tapia, H. H. Yeh, E. Diaz, and L. G. Aguayo Developmental-Dependent Action of Microtubule Depolymerization on the Function and Structure of Synaptic Glycine Receptor Clusters in Spinal Neurons J Neurophysiol, February 1, 2004; 91(2): 1036 - 1049. [Abstract] [Full Text] [PDF]

				P. Legendre, E. Muller, C. I. Badiu, J. Meier, C. Vannier, and A. Triller Desensitization of Homomeric alpha 1 Glycine Receptor Increases with Receptor Density Mol. Pharmacol., October 1, 2002; 62(4): 817 - 827. [Abstract] [Full Text] [PDF]

				M. Rosenberg, J. Meier, A. Triller, and C. Vannier Dynamics of Glycine Receptor Insertion in the Neuronal Plasma Membrane J. Neurosci., July 15, 2001; 21(14): 5036 - 5044. [Abstract] [Full Text] [PDF]