The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

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S. E. Bates, W. Y. Medina-Perez, G. Kohlhagen, S. Antony, T. Nadjem, R. W. Robey, and Y. Pommier
ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
J. Pharmacol. Exp. Ther., August 1, 2004; 310(2): 836 - 842.
[Abstract] [Full Text] [PDF]

J. W. Polli, T. M. Baughman, J. E. Humphreys, K. H. Jordan, A. L. Mote, L. O. Webster, R. J. Barnaby, G. Vitulli, L. Bertolotti, K. D. Read, et al.
THE SYSTEMIC EXPOSURE OF AN N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST IS LIMITED IN MICE BY THE P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN EFFLUX TRANSPORTERS
Drug Metab. Dispos., July 1, 2004; 32(7): 722 - 726.
[Abstract] [Full Text] [PDF]

A. Gupta, Y. Zhang, J. D. Unadkat, and Q. Mao
HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)
J. Pharmacol. Exp. Ther., July 1, 2004; 310(1): 334 - 341.
[Abstract] [Full Text] [PDF]

S. Cisternino, C. Mercier, F. Bourasset, F. Roux, and J.-M. Scherrmann
Expression, Up-Regulation, and Transport Activity of the Multidrug-Resistance Protein Abcg2 at the Mouse Blood-Brain Barrier
Cancer Res., May 1, 2004; 64(9): 3296 - 3301.
[Abstract] [Full Text] [PDF]

P. J. Houghton, G. S. Germain, F. C. Harwood, J. D. Schuetz, C. F. Stewart, E. Buchdunger, and P. Traxler
Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro
Cancer Res., April 1, 2004; 64(7): 2333 - 2337.
[Abstract] [Full Text] [PDF]

P. L. R. Ee, S. Kamalakaran, D. Tonetti, X. He, D. D. Ross, and W. T. Beck
Identification of a Novel Estrogen Response Element in the Breast Cancer Resistance Protein (ABCG2) Gene
Cancer Res., February 15, 2004; 64(4): 1247 - 1251.
[Abstract] [Full Text] [PDF]

J van der Heijden, M C de Jong, B A C Dijkmans, W F Lems, R Oerlemans, I Kathmann, G L Scheffer, R J Scheper, Y G Assaraf, and G Jansen
Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs
Ann Rheum Dis, February 1, 2004; 63(2): 131 - 137.
[Abstract] [Full Text] [PDF]

H. H. Yang, M. H. Ma, R. A. Vescio, and J. R. Berenson
Overcoming Drug Resistance in Multiple Myeloma: The Emergence of Therapeutic Approaches to Induce Apoptosis
J. Clin. Oncol., November 15, 2003; 21(22): 4239 - 4247.
[Abstract] [Full Text] [PDF]

S. L. A. Plasschaert, D. M. van der Kolk, E. S. J. M. de Bont, W. A. Kamps, K. Morisaki, S. E. Bates, G. L. Scheffer, R. J. Scheper, E. Vellenga, and E. G. E. de Vries
The Role of Breast Cancer Resistance Protein in Acute Lymphoblastic Leukemia
Clin. Cancer Res., November 1, 2003; 9(14): 5171 - 5177.
[Abstract] [Full Text] [PDF]

Y.-Q. Zhu, K.-X. Xu, B. Luo, J.-W. Wang, and X.-Y. Chen
An ATP-Binding Cassette Transporter GhWBC1 from Elongating Cotton Fibers
Plant Physiology, October 1, 2003; 133(2):

				H. Wang, E.-W. Lee, L. Zhou, P. C. K. Leung, D. D. Ross, J. D. Unadkat, and Q. Mao Progesterone Receptor (PR) Isoforms PRA and PRB Differentially Regulate Expression of the Breast Cancer Resistance Protein in Human Placental Choriocarcinoma BeWo Cells Mol. Pharmacol., March 1, 2008; 73(3): 845 - 854. [Abstract] [Full Text] [PDF]

				L. Yin, P. Castagnino, and R. K. Assoian ABCG2 Expression and Side Population Abundance Regulated by a Transforming Growth Factor {beta}-Directed Epithelial-Mesenchymal Transition Cancer Res., February 1, 2008; 68(3): 800 - 807. [Abstract] [Full Text] [PDF]

				H. Liu, Y. Liu, and J.-T. Zhang A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction Mol. Cancer Ther., February 1, 2008; 7(2): 263 - 270. [Abstract] [Full Text] [PDF]

				H. Glavinas, E. Kis, A. Pal, R. Kovacs, M. Jani, E. Vagi, E. Molnar, S. Bansaghi, Z. Kele, T. Janaky, et al. ABCG2 (Breast Cancer Resistance Protein/Mitoxantrone Resistance-Associated Protein) ATPase Assay: A Useful Tool to Detect Drug-Transporter Interactions Drug Metab. Dispos., September 1, 2007; 35(9): 1533 - 1542. [Abstract] [Full Text] [PDF]

				K. Takenaka, J. A. Morgan, G. L. Scheffer, M. Adachi, C. F. Stewart, D. Sun, M. Leggas, K. F.K. Ejendal, C. A. Hrycyna, and J. D. Schuetz Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution Cancer Res., July 15, 2007; 67(14): 6965 - 6972. [Abstract] [Full Text] [PDF]

				T. Yamagata, H. Kusuhara, M. Morishita, K. Takayama, H. Benameur, and Y. Sugiyama Improvement of the Oral Drug Absorption of Topotecan through the Inhibition of Intestinal Xenobiotic Efflux Transporter, Breast Cancer Resistance Protein, by Excipients Drug Metab. Dispos., July 1, 2007; 35(7): 1142 - 1148. [Abstract] [Full Text] [PDF]

				S. Vibet, K. Maheo, J. Gore, P. Dubois, P. Bougnoux, and I. Chourpa Differential Subcellular Distribution of Mitoxantrone in Relation to Chemosensitization in Two Human Breast Cancer Cell Lines Drug Metab. Dispos., May 1, 2007; 35(5): 822 - 828. [Abstract] [Full Text] [PDF]

				D. Leveque and F. Jehl Molecular Pharmacokinetics of Catharanthus (Vinca) Alkaloids J. Clin. Pharmacol., May 1, 2007; 47(5): 579 - 588. [Abstract] [Full Text] [PDF]

				S. S. Lee, H.-E. Jeong, J.-M. Yi, H.-J. Jung, J.-E. Jang, E.-Y. Kim, S.-J. Lee, and J.-G. Shin Identification and Functional Assessment of BCRP Polymorphisms in a Korean Population Drug Metab. Dispos., April 1, 2007; 35(4): 623 - 632. [Abstract] [Full Text] [PDF]

				W. G. Telford, J. Bradford, W. Godfrey, R. W. Robey, and S. E. Bates Side Population Analysis Using a Violet-Excited Cell-Permeable DNA Binding Dye Stem Cells, April 1, 2007; 25(4): 1029 - 1036. [Abstract] [Full Text] [PDF]

				J. Weiss, J. Rose, C. H. Storch, N. Ketabi-Kiyanvash, A. Sauer, W. E. Haefeli, and T. Efferth Modulation of human BCRP (ABCG2) activity by anti-HIV drugs J. Antimicrob. Chemother., February 1, 2007; 59(2): 238 - 245. [Abstract] [Full Text] [PDF]

				E. Savary, J. P. Hugnot, Y. Chassigneux, C. Travo, C. Duperray, T. Van De Water, and A. Zine Distinct Population of Hair Cell Progenitors Can Be Isolated from the Postnatal Mouse Cochlea Using Side Population Analysis Stem Cells, February 1, 2007; 25(2): 332 - 339. [Abstract] [Full Text] [PDF]

				Z. E. Sauna and S. V. Ambudkar About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work Mol. Cancer Ther., January 1, 2007; 6(1): 13 - 23. [Abstract] [Full Text] [PDF]

				M. Ron, M. Cohen-Zinder, C. Peter, J. I. Weller, and G. Erhardt Short Communication: A Polymorphism in ABCG2 in Bos indicus and Bos taurus Cattle Breeds J Dairy Sci, December 1, 2006; 89(12): 4921 - 4923. [Abstract] [Full Text] [PDF]

				J. G. Turner, J. L. Gump, C. Zhang, J. M. Cook, D. Marchion, L. Hazlehurst, P. Munster, M. J. Schell, W. S. Dalton, and D. M. Sullivan ABCG2 expression, function, and promoter methylation in human multiple myeloma Blood, December 1, 2006; 108(12): 3881 - 3889. [Abstract] [Full Text] [PDF]

				R. Cabana, E. G. Frolova, V. Kapoor, R. A. Thomas, A. Krishan, and W. G. Telford The Minimal Instrumentation Requirements for Hoechst Side Population Analysis: Stem Cell Analysis on Low-Cost Flow Cytometry Platforms Stem Cells, November 1, 2006; 24(11): 2573 - 2581. [Abstract] [Full Text] [PDF]

				J. A. Seamon, C. A. Rugg, S. Emanuel, A. M. Calcagno, S. V. Ambudkar, S. A. Middleton, J. Butler, V. Borowski, and L. M. Greenberger Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor. Mol. Cancer Ther., October 1, 2006; 5(10): 2459 - 2467. [Abstract] [Full Text] [PDF]

				S. Leonce, L. Kraus-Berthier, R. M. Golsteyn, M.-H. David-Cordonnier, C. Tardy, A. Lansiaux, V. Poindessous, A. K. Larsen, and A. Pierre Generation of replication-dependent double-strand breaks by the novel n2-g-alkylator s23906-1. Cancer Res., July 15, 2006; 66(14): 7203 - 7210. [Abstract] [Full Text] [PDF]

				A Mohan, M Kandalam, H L Ramkumar, L Gopal, and S Krishnakumar Stem cell markers: ABCG2 and MCM2 expression in retinoblastoma Br. J. Ophthalmol., July 1, 2006; 90(7): 889 - 893. [Abstract] [Full Text] [PDF]

				H. Saito, H. Hirano, H. Nakagawa, T. Fukami, K. Oosumi, K. Murakami, H. Kimura, T. Kouchi, M. Konomi, E. Tao, et al. A New Strategy of High-Speed Screening and Quantitative Structure-Activity Relationship Analysis to Evaluate Human ATP-Binding Cassette Transporter ABCG2-Drug Interactions J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1114 - 1124. [Abstract] [Full Text] [PDF]

				C. S. Morrow, C. Peklak-Scott, B. Bishwokarma, T. E. Kute, P. K. Smitherman, and A. J. Townsend Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediates Resistance to Mitoxantrone via Glutathione-Dependent Drug Efflux Mol. Pharmacol., April 1, 2006; 69(4): 1499 - 1505. [Abstract] [Full Text] [PDF]

				Y. Liu, H. Liu, B. Han, and J.-T. Zhang Identification of 14-3-3{sigma} as a Contributor to Drug Resistance in Human Breast Cancer Cells Using Functional Proteomic Analysis. Cancer Res., March 15, 2006; 66(6): 3248 - 3255. [Abstract] [Full Text] [PDF]

				U. Henriksen, J. U. Fog, T. Litman, and U. Gether Identification of Intra- and Intermolecular Disulfide Bridges in the Multidrug Resistance Transporter ABCG2 J. Biol. Chem., November 4, 2005; 280(44): 36926 - 36934. [Abstract] [Full Text] [PDF]

				Z. Benderra, A. M. Faussat, L. Sayada, J.-Y. Perrot, R. Tang, D. Chaoui, H. Morjani, C. Marzac, J.-P. Marie, and O. Legrand MRP3, BCRP, and P-Glycoprotein Activities are Prognostic Factors in Adult Acute Myeloid Leukemia Clin. Cancer Res., November 1, 2005; 11(21): 7764 - 7772. [Abstract] [Full Text] [PDF]

				D. White, V. Saunders, A. B. Lyons, S. Branford, A. Grigg, L. B. To, and T. Hughes In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML Blood, October 1, 2005; 106(7): 2520 - 2526. [Abstract] [Full Text] [PDF]

				A. Shafran, I. Ifergan, E. Bram, G. Jansen, I. Kathmann, G. J. Peters, R. W. Robey, S. E. Bates, and Y. G. Assaraf ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates Cancer Res., September 15, 2005; 65(18): 8414 - 8422. [Abstract] [Full Text] [PDF]

				X.-f. Zhou, X. Yang, Q. Wang, R. A. Coburn, and M. E. Morris EFFECTS OF DIHYDROPYRIDINES AND PYRIDINES ON MULTIDRUG RESISTANCE MEDIATED BY BREAST CANCER RESISTANCE PROTEIN: IN VITRO AND IN VIVO STUDIES Drug Metab. Dispos., August 1, 2005; 33(8): 1220 - 1228. [Abstract] [Full Text] [PDF]

				M. Cohen-Zinder, E. Seroussi, D. M. Larkin, J. J. Loor, A. E.-v. d. Wind, J.-H. Lee, J. K. Drackley, M. R. Band, A.G. Hernandez, M. Shani, et al. Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle Genome Res., July 1, 2005; 15(7): 936 - 944. [Abstract] [Full Text] [PDF]

				R. R. Vethanayagam, H. Wang, A. Gupta, Y. Zhang, F. Lewis, J. D. Unadkat, and Q. Mao FUNCTIONAL ANALYSIS OF THE HUMAN VARIANTS OF BREAST CANCER RESISTANCE PROTEIN: I206L, N590Y, AND D620N Drug Metab. Dispos., June 1, 2005; 33(6): 697 - 705. [Abstract] [Full Text] [PDF]

				C. Q. Xia, N. Liu, D. Yang, G. Miwa, and L.-S. Gan EXPRESSION, LOCALIZATION, AND FUNCTIONAL CHARACTERISTICS OF BREAST CANCER RESISTANCE PROTEIN IN CACO-2 CELLS Drug Metab. Dispos., May 1, 2005; 33(5): 637 - 643. [Abstract] [Full Text] [PDF]