Tight junctions are membrane microdomains

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Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W. and Fu, P. C (1974). Enzymatic determination of total serum cholesterol. Clin. Chem 20, 470-5.[Abstract]

Anderson, J. M., Stevenson, B. R., Jesaitis, L. A., Goodenough, D. A. and Mooseker, M. S (1988). Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells. J. Cell Biol 106, 1141-9.[Abstract/Free Full Text]

Anderson, J. M. and Van Itallie, C. M (1995). Tight junctions and the molecular basis for regulation of paracellular permeability. Am. J. Physiol 269, 467-75.

Anderson, R. G (1993). Caveolae: where incoming and outgoing messengers meet. Proc. Natl. Acad. Sci. USA 90, 10909-13.[Abstract/Free Full Text]

Brown, D. A. and Rose, J. K (1992). Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68, 533-44.[Medline]

Cereijido, M., Gonzalez-Mariscal, L. and Borboa, L (1983). Occluding junctions and paracellular pathways studied in monolayers of MDCK cells. J. Exp. Biol 106, 205-15.[Abstract/Free Full Text]

Fanning, A. S., Jameson, B. J., Jesaitis, L. A. and Anderson, J. M (1998). The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J. Biol. Chem 273, 29745-53.[Abstract/Free Full Text]

Farquhar, M. G. and Palade, G. E (1963). Junctional complexes in various epithelia. J. Cell Biol 17, 375-412.[Abstract/Free Full Text]

Feltkamp, C. A. and Van der Waerden, A. W (1983). Junction formation between cultured normal rat hepatocytes. An ultrastructural study on the presence of cholesterol and the structure of developing tight-junction strands. J. Cell Sci 63, 271-86.[Abstract]

Friedrichson, T. and Kurzchalia, T. V (1998). Microdomains of GPI-anchored proteins in living cells revealed by crosslinking. Nature 394, 802-5.[Medline]

Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K. and Tsukita, S (1998). Claudin-1 and-2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol 141, 1539-50.[Abstract/Free Full Text]

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S (1993). Occludin: a novel integral membrane protein localizing at tight junctions [see comments]. J. Cell Biol 123, 1777-88.[Abstract/Free Full Text]

Gumbiner, B (1987). Structure, biochemistry, and assembly of epithelial tight junctions. Am. J. Physiol 253, 749-58.

Gumbiner, B. M (1993). Breaking through the tight junction barrier [comment]. J. Cell Biol 123, 1631-3.[Free Full Text]

Harder, T. and Simons, K (1997). Caveolae, DIGs, and the dynamics ofsphingolipid-cholesterol microdomains. Curr. Opin. Cell Biol 9, 534-42.[Medline]

Jesaitis, L. A. and Goodenough, D. A (1994). Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J. Cell Biol 124, 949-61.[Abstract/Free Full Text]

Kachar, B. and Reese, T. S (1982). Evidence for the lipidic nature of tight junction strands. Nature 296, 464-6.[Medline]

Kaoutzani, P., Parkos, C. A., Delp-Archer, C. and Madara, J. L (1993). Isolation of plasma membrane fractions from the intestinal epithelial model T84. Am. J. Physiol 264, 1327-35.

Li, S., Okamoto, T., Chun, M., Sargiacomo, M., Casanova, J. E., Hansen, S. H., Nishimoto, I. and Lisanti, M. P (1995). Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J. Biol. Chem 270, 15693-701.[Abstract/Free Full Text]

Lisanti, M. P., Scherer, P. E., Vidugiriene, J., Tang, Z., Hermanowski-Vosatka, A., Tu, Y. H., Cook, R. F. and Sargiacomo, M (1994). Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease. J. Cell Biol 126, 111-26.[Abstract/Free Full Text]

Lisanti, M. P., Tang, Z., Scherer, P. E., Kubler, E., Koleske, A. J. and Sargiacomo, M (1995). Caveolae, transmembrane signalling and cellular transformation. Mol. Membr. Biol 12, 121-4.[Medline]

Lisanti, M. P., Tang, Z. L. and Sargiacomo, M (1993). Caveolin forms a hetero-oligomeric protein complex that interacts with an apical GPI-linked protein: implications for the biogenesis of caveolae. J. Cell Biol 123, 595-604.[Abstract/Free Full Text]

Madara, J. L (1988). Tight junction dynamics: is paracellular transport regulated?. Cell 53, 497-8.[Medline]

Madara, J. L. and Dharmsathaphorn, K (1985). Occluding junction structure-function relationships in a cultured epithelial monolayer. J. Cell Biol 101, 2124-2133.[Abstract/Free Full Text]

Madara, J. L., Moore, R. and Carlson, S (1987). Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction. Am. J. Physiol 253, 854-61.

Madara, J. L., Parkos, C., Colgan, S., Nusrat, A., Atisook, K. and Kaoutzani, P (1992). The movement of solutes and cells across tight junctions. Ann. NY Acad. Sci 664, 47-60.[Medline]

Madara, J. L., Stafford, J., Barenberg, D. and Carlson, S (1988). Functional coupling of tight junctions and microfilaments in T84 monolayers. Am. J. Physiol 254, 416-23.

Madara, J. L., Stafford, J., Dharmsathaphorn, K. and Carlson, S (1987). Structural analysis of a human intestinal epithelial cell line. Gastroenterology 92, 1133-45.[Medline]

Nusrat, A., Parkos, C. A., Bacarra, A. E., Godowski, P. J., Delp-Archer, C., Rosen, E. M. and Madara, J. L (1994). Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J. Clin. Invest 93, 2056-65.

Parkos, C. A., Delp, C., Arnaout, M. A. and Madara, J. L (1991). Neutrophil Migration Across a Cultured Intestinal Epithelium: Dependence on a CD1lb/CD18 \320 Mediated Event and Enhanced Efficiency in the Physiologic Direction. J. Clin. Invest 88, 1605-12.

Parton, R. G. and Simons, K (1995). Digging into caveolae [comment]. Science 269, 1398-9.[Free Full Text]

Pinto da Silva, P. and Kachar, B (1982). On tight-junction structure. Cell 28, 441-50.[Medline]

Saitou, M., Fujimoto, K., Doi, Y., Itoh, M., Fujimoto, T., Furuse, M., Takano, H., Noda, T. and Tsukita, S (1998). Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J. Cell Biol 141, 397-408.[Abstract/Free Full Text]

Sakakibara, A., Furuse, M., Saitou, M., Ando-Akatsuka, Y. and Tsukita, S (1997). Possible involvement of phosphorylation of occludin in tight junction formation. J. Cell Biol 137, 1393-401.[Abstract/Free Full Text]

Sargiacomo, M., Sudol, M., Tang, Z. and Lisanti, M. P (1993). Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J. Cell Biol 122, 789-807.[Abstract/Free Full Text]

Scheiffele, P., Verkade, P., Fra, A. M., Virta, H., Simons, K. and Ikonen,E (1998). Caveolin-1 and-2 in the exocytic pathway of MDCK cells. J. Cell Biol 140, 795-806.[Abstract/Free Full Text]

Scherer, P. E., Okamoto, T., Chun, M., Nishimoto, I., Lodish, H. F. and Lisanti, M. P (1996). Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc. Natl. Acad. Sci. USA 93, 131-5.[Abstract/Free Full Text]

Simons, K. and Ikonen, E (1997). Functional rafts in cell membranes. Nature 387, 569-72.[Medline]

Song, S. K., Li, S., Okamoto, T., Quilliam, L. A., Sargiacomo, M. and Lisanti, M. P (1996). Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J. Biol. Chem 271, 9690-7.[Abstract/Free Full Text]

Stankewich, M. C., Francis, S. A., Vu, Q. U., Schneeberger, E. E. and Lynch, R. D (1996). Alterations in cell cholesterol content modulate Ca(2+)-induced tight junction assembly by MDCK cells. Lipids 31, 817-28.[Medline]

Stevenson, B. R., Anderson, J. M., Goodenough, D. A. and Mooseker, M. S (1988). Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance. J. Cell Biol 107, 2401-8.[Abstract/Free Full Text]

Stevenson, B. R. and Goodenough, D. A (1984). Zonulae occludentes injunctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterization. J. Cell Biol 98, 1209-21.[Abstract/Free Full Text]

Stevenson, B. R., Siliciano, J. D., Mooseker, M. S. and Goodenough, D. A (1986). Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol 103, 755-66.[Abstract/Free Full Text]

Tsukita, S., Furuse, M. and Itoh, M (1996). Molecular dissection of tight junctions. Cell Struct. Funct 21, 381-5.[Medline]

Varma, R. and Mayor, S (1998). GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 394, 798-801.[Medline]

Weber, E., Berta, G., Tousson, A., St John, P., Green, M. W., Gopalokrishnan, U., Jilling, T., Sorscher, E. J., Elton, T. S., Abrahamson, D. R. et al (1994). Expression and polarized targeting of a rab3 isoform in epithelial cells. J. Cell Biol 125, 583-94.[Abstract/Free Full Text]

Wolf, A. A., Jobling, M. G., Wimer-Mackin, S., Ferguson-Maltzman, M., Madara, J. L., Holmes, R. K. and Lencer, W. I (1998). Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia. J. Cell Biol 141, 917-27.[Abstract/Free Full Text]

Wong, V (1997). Phosphorylation of occludin correlates with occludin localization and function at the tight junction. Am. J. Physiol 273, 1859-67.

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[Abstract] [Full Text] [PDF]

D. Wustner, A. Herrmann, M. Hao, and F. R. Maxfield
Rapid Nonvesicular Transport of Sterol between the Plasma Membrane Domains of Polarized Hepatic Cells
J. Biol. Chem., August 9, 2002; 277(33): 30325 - 30336.
[Abstract] [Full Text] [PDF]

H. A. Edens, B. P. Levi, D. L. Jaye, S. Walsh, T. A. Reaves, J. R. Turner, A. Nusrat, and C. A. Parkos
Neutrophil Transepithelial Migration: Evidence for Sequential, Contact-Dependent Signaling Events and Enhanced Paracellular Permeability Independent of Transjunctional Migration
J. Immunol., July 1, 2002; 169(1): 476 - 486.
[Abstract] [Full Text] [PDF]

A.-M. Marzesco, I. Dunia, R. Pandjaitan, M. Recouvreur, D. Dauzonne, E. L. Benedetti, D. Louvard, and A. Zahraoui
The Small GTPase Rab13 Regulates Assembly of Functional Tight Junctions in Epithelial Cells
Mol. Biol. Cell, June 1, 2002; 13(6): 1819 - 1831.
[Abstract] [Full Text] [PDF]

				M. Brazzoli, A. Bianchi, S. Filippini, A. Weiner, Q. Zhu, M. Pizza, and S. Crotta CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human Hepatocytes J. Virol., September 1, 2008; 82(17): 8316 - 8329. [Abstract] [Full Text] [PDF]

				Y. Zhong, E. J. Smart, B. Weksler, P.-O. Couraud, B. Hennig, and M. Toborek Caveolin-1 Regulates Human Immunodeficiency Virus-1 Tat-Induced Alterations of Tight Junction Protein Expression via Modulation of the Ras Signaling J. Neurosci., July 30, 2008; 28(31): 7788 - 7796. [Abstract] [Full Text] [PDF]

				P. Nava, M. G. Laukoetter, A. M. Hopkins, O. Laur, K. Gerner-Smidt, K. J. Green, C. A. Parkos, and A. Nusrat Desmoglein-2: A Novel Regulator of Apoptosis in the Intestinal Epithelium Mol. Biol. Cell, November 1, 2007; 18(11): 4565 - 4578. [Abstract] [Full Text] [PDF]

				E. Burgermeister, X. Xing, C. Rocken, M. Juhasz, J. Chen, M. Hiber, K. Mair, M. Shatz, M. Liscovitch, R. M. Schmid, et al. Differential Expression and Function of Caveolin-1 in Human Gastric Cancer Progression Cancer Res., September 15, 2007; 67(18): 8519 - 8526. [Abstract] [Full Text] [PDF]

				K. Wosik, R. Cayrol, A. Dodelet-Devillers, F. Berthelet, M. Bernard, R. Moumdjian, A. Bouthillier, T. L. Reudelhuber, and A. Prat Angiotensin II Controls Occludin Function and Is Required for Blood Brain Barrier Maintenance: Relevance to Multiple Sclerosis J. Neurosci., August 22, 2007; 27(34): 9032 - 9042. [Abstract] [Full Text] [PDF]

				I. Beau, J. Cotte-Laffitte, R. Amsellem, and A. L. Servin A Protein Kinase A-Dependent Mechanism by Which Rotavirus Affects the Distribution and mRNA Level of the Functional Tight Junction-Associated Protein, Occludin, in Human Differentiated Intestinal Caco-2 Cells J. Virol., August 15, 2007; 81(16): 8579 - 8586. [Abstract] [Full Text] [PDF]

				A. T. Blikslager, A. J. Moeser, J. L. Gookin, S. L. Jones, and J. Odle Restoration of Barrier Function in Injured Intestinal Mucosa Physiol Rev, April 1, 2007; 87(2): 545 - 564. [Abstract] [Full Text] [PDF]

				B. A. Babbin, C. A. Parkos, K. J. Mandell, L. M. Winfree, O. Laur, A. I. Ivanov, and A. Nusrat Annexin 2 Regulates Intestinal Epithelial Cell Spreading and Wound Closure through Rho-Related Signaling Am. J. Pathol., March 1, 2007; 170(3): 951 - 966. [Abstract] [Full Text] [PDF]

				L. Song, S. Ge, and J. S. Pachter Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells Blood, February 15, 2007; 109(4): 1515 - 1523. [Abstract] [Full Text] [PDF]

				M. Endemann, H. Bergmeister, B. Bidmon, M. Boehm, D. Csaicsich, L. Malaga-Dieguez, K. Arbeiter, H. Regele, K. Herkner, and C. Aufricht Evidence for HSP-mediated cytoskeletal stabilization in mesothelial cells during acute experimental peritoneal dialysis Am J Physiol Renal Physiol, January 1, 2007; 292(1): F47 - F56. [Abstract] [Full Text] [PDF]

				M. L. Chen, Z. Ge, J. G. Fox, and D. B. Schauer Disruption of Tight Junctions and Induction of Proinflammatory Cytokine Responses in Colonic Epithelial Cells by Campylobacter jejuni Infect. Immun., December 1, 2006; 74(12): 6581 - 6589. [Abstract] [Full Text] [PDF]

				G. M. Verghese, M. F. Gutknecht, and G. H. Caughey Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1258 - C1270. [Abstract] [Full Text] [PDF]

				P. Viegas, N. Chaverot, H. Enslen, N. Perriere, P.-O. Couraud, and S. Cazaubon Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes J. Cell Sci., November 15, 2006; 119(22): 4634 - 4643. [Abstract] [Full Text] [PDF]

				L. Shen, E. D. Black, E. D. Witkowski, W. I. Lencer, V. Guerriero, E. E. Schneeberger, and J. R. Turner Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure J. Cell Sci., May 15, 2006; 119(10): 2095 - 2106. [Abstract] [Full Text] [PDF]

				A. Ikari, S. Matsumoto, H. Harada, K. Takagi, H. Hayashi, Y. Suzuki, M. Degawa, and M. Miwa Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctions J. Cell Sci., May 1, 2006; 119(9): 1781 - 1789. [Abstract] [Full Text] [PDF]

				V. Lievin-Le Moal and A. L. Servin The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota Clin. Microbiol. Rev., April 1, 2006; 19(2): 315 - 337. [Abstract] [Full Text] [PDF]

				M. Anitei, M. Ifrim, M.-A. Ewart, A. E. Cowan, J. H. Carson, R. Bansal, and S. E. Pfeiffer A role for Sec8 in oligodendrocyte morphological differentiation J. Cell Sci., March 1, 2006; 119(5): 807 - 818. [Abstract] [Full Text] [PDF]

				S. Miotti, A. Tomassetti, I. Facetti, E. Sanna, V. Berno, and S. Canevari Simultaneous Expression of Caveolin-1 and E-Cadherin in Ovarian Carcinoma Cells Stabilizes Adherens Junctions through Inhibition of src-Related Kinases Am. J. Pathol., November 1, 2005; 167(5): 1411 - 1427. [Abstract] [Full Text] [PDF]

				L. Shen and J. R. Turner Actin Depolymerization Disrupts Tight Junctions via Caveolae-mediated Endocytosis Mol. Biol. Cell, September 1, 2005; 16(9): 3919 - 3936. [Abstract] [Full Text] [PDF]

				T. A. Brooks, B. T. Hawkins, J. D. Huber, R. D. Egleton, and T. P. Davis Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H738 - H743. [Abstract] [Full Text] [PDF]

				X. Guo, J. N. Rao, L. Liu, T. Zou, K. M. Keledjian, D. Boneva, B. S. Marasa, and J.-Y. Wang Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1159 - G1169. [Abstract] [Full Text] [PDF]

				A. I. Ivanov, D. Hunt, M. Utech, A. Nusrat, and C. A. Parkos Differential Roles for Actin Polymerization and a Myosin II Motor in Assembly of the Epithelial Apical Junctional Complex Mol. Biol. Cell, June 1, 2005; 16(6): 2636 - 2650. [Abstract] [Full Text] [PDF]

				C. M. Van Itallie, T. M. Gambling, J. L. Carson, and J. M. Anderson Palmitoylation of claudins is required for efficient tight-junction localization J. Cell Sci., April 1, 2005; 118(7): 1427 - 1436. [Abstract] [Full Text] [PDF]

				F. Wang, W. V. Graham, Y. Wang, E. D. Witkowski, B. T. Schwarz, and J. R. Turner Interferon-{gamma} and Tumor Necrosis Factor-{alpha} Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression Am. J. Pathol., February 1, 2005; 166(2): 409 - 419. [Abstract] [Full Text] [PDF]

				X. F. Figueroa, B. E. Isakson, and B. R. Duling Connexins: Gaps in Our Knowledge of Vascular Function Physiology, October 1, 2004; 19(5): 277 - 284. [Abstract] [Full Text] [PDF]

				D. D. Mruk and C. Y. Cheng Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis Endocr. Rev., October 1, 2004; 25(5): 747 - 806. [Abstract] [Full Text] [PDF]

				M. Cereijido, R. G. Contreras, and L. Shoshani Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans Physiol Rev, October 1, 2004; 84(4): 1229 - 1262. [Abstract] [Full Text] [PDF]

				A. M. Hopkins, M. Bruewer, G. T. Brown, A. A. Pineda, J. J. Ha, L. M. Winfree, S. V. Walsh, B. A. Babbin, and A. Nusrat Epithelial cell spreading induced by hepatocyte growth factor influences paxillin protein synthesis and posttranslational modification Am J Physiol Gastrointest Liver Physiol, October 1, 2004; 287(4): G886 - G898. [Abstract] [Full Text] [PDF]

				D. B. N. Lee, N. Jamgotchian, S. G. Allen, F. W. K. Kan, and I. L. Hale Annexin A2 heterotetramer: role in tight junction assembly Am J Physiol Renal Physiol, September 1, 2004; 287(3): F481 - F491. [Abstract] [Full Text] [PDF]

				S. Seveau, H. Bierne, S. Giroux, M.-C. Prevost, and P. Cossart Role of lipid rafts in E-cadherin- and HGF-R/Met-mediated entry of Listeria monocytogenes into host cells J. Cell Biol., August 30, 2004; 166(5): 743 - 753. [Abstract] [Full Text] [PDF]