Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation: auto-paracrine role during endochondral bone formation

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Ahmed, A., Dunk, C., Kniss, D. and Wilkes, M (1997). Role of VEGF receptor-1 (Flt-1) in mediating calcium dependent nitric oxide release and limiting DNA synthesis in human trophoblast cells. Lab. Invest 76, 779-791.[Medline]

Aitkenhead, M., Christ, B., Eichmann, A., Feucht, M., Wilson, D. J. and Wilting, J (1998). Paracrine and autocrine regulation of vascular endothelial growth factor during tissue differentiation in the quail. Dev. Dynam 212, 1-13.[Medline]

Albini, A., Iwamoto, Y., Kleinman, H. K., Martin, G. R., Aaronson, S. A., Kozlowski, J. M. and McEwan, R. N (1987). A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 4, 3239-3245.

Alini, M., Marriott, A., Chen, T., Abe, S. and Poole, A. R (1996). A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation. Dev. Biol 176, 124-132.[Medline]

Baron, J., Klen, K. O., Yanovski, J. A., Novosad, J. A., Bacher, J. D., Bolander, M. E. and Cutler, G. B (1994). Induction of growth platecartilage ossification by basic fibroblast growth factor. Endocrinology 135, 2790-2793.[Abstract]

Bianco, P., Descalzi Cancedda, F., Riminucci, M. and Cancedda, R (1998). Bone formation via cartilage models: the \324borderline' chondrocyte. Matrix Biol 17, 185-192.[Medline]

Brown, L. F., Detmar, M., Tognazzi, K., Abu-Jawdeh, G. and Iruela-Arispe, M. L (1997). Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor/vascular endothelial growth factor. Lab. Invest 76, 245-255.[Medline]

Brown, R. A. and McFarland, C. D (1992). Regulation of growth plate cartilage degradation in vitro: effects of calcification and a low molecular mass angiogenic factor (ESAF). Bone 17, 49-57.

Carlevaro, M. F., Albini, A., Ribatti, D., Gentili, C., Benelli, R., Cermelli, S., Cancedda, R. and Descalzi Cancedda, F (1997). Transferrin promotes endothelial cell migration and invasion: implication in cartilage neovascularization. J. Cell Biol 136, 1375-1384.[Abstract/Free Full Text]

Castagnola, P., Moro, G., Descalzi-Cancedda, F. and Cancedda, R (1986). Type X collagen synthesis during in vitro development of chick embryo tibial chondrocytes. J. Cell Biol 102, 2310-2317.[Abstract/Free Full Text]

Claffey, K. P., Wilkinson, W. O. and Spegelman, B. M (1992). Vascular endothelial growth factor regulation by cell differentiation and activated second messenger pathways. J. Biol. Chem 267, 16317-16322.[Abstract/Free Full Text]

De Vries, C., Escobedo, J. A, Ueno, H., Houck, K., Ferrara, N. and Williams, L. T (1992). The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255, 989-991.[Abstract/Free Full Text]

Descalzi Cancedda, F., Gentili, C., Manduca, P. and Cancedda, R (1992). Hypertrophic chondrocytes undergo further differentiation in culture. J. Cell Biol 117, 427-435.[Abstract/Free Full Text]

Descalzi Cancedda, F., Melchiori, A., Benelli, R., Gentili, C., Masiello, L., Campanile, G., Cancedda, R. and Albini, A (1995). Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. Eur. J. Cell Biol 66, 60-68.[Medline]

Detmar, M., Brown, L. F., Berse, B., Jackman, R. W., Elicker, B. M., Dvorak H. F. and Claffey, K. P (1997). Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J. Invest. Dermatol 108, 263-268.[Medline]

Dvorak, H. F., Brown, L. F., Detmar, M. and Dvorak, A. M (1995). Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol 146, 1029-1039.[Abstract]

Eichmann, A., Marcelle, C., Breant, C. and Le Douarin, N. M (1996). Molecular cloning of Quek 1 and 2, two quail vascular endothelial growth factor (VEGF) receptor-like molecules. Gene 174, 3-8.[Medline]

Fava, R. A., Olsen, N. J., Spencer-Green, G., Yeo, K. T., Yeo, T. K., Berse, B., Jackman, R. W., Senger, D. R., Dvorak, H. F. and Brown, L. F (1994). Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissues. J. Exp. Med 180, 341-346.[Abstract/Free Full Text]

Ferrara, N., Houck, K., Jakeman L. and Leung, D. W (1992). Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocrine Rev 13, 18-32.[Medline]

Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K. S., Powell-Braxton, L., Hillan, K. J. and Moore, M. W (1996). Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442.[Medline]

Flamme, I., von Reutern, M., Drexler, H. C. A., Syed-Ali, K. and Risau, W (1995). Overexpression of vascular endothelial growth factor in the avian embryo induces hypervascularization and increased vascular permeability without alterations of embryonic pattern formation. Dev. Biol 171, 399-414.[Medline]

Gentili, C., Cermelli, S., Tacchetti, C., Cossu, G., Cancedda, R. and Descalzi Cancedda, F (1998). Expression of the extracellular fatty acid binding protein (Ex-FABP) during muscle fiber formation in vivo and in vitro. Exp. Cell Res 242, 410-418.[Medline]

Harada, S., Nagy, J. A., Sullivan, K. A., Thomas, K. A., Endo, N., Rodan, G. A. and Rodan, S. B (1994). Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. J. Clin. Invest 93, 2490-2496.

Jakeman, L. B., Winer, J, Bennet, G. L., Altar, C. A. and Ferrara, N (1992). Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J. Clin. Invest 89, 244-253.

Jakeman, L. B., Armanini, M., Phillips, H. S. and Ferrara, N (1993). Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor VEGF suggests a role for this protein in vasculogenesis and angiogenesis. Endocrinology 133, 848-859.[Abstract]

Kato, Y. and Iwamoto, M (1990). Fibroblast growth factor is an inhibitor of chondrocyte terminal differentation. J. Biol. Chem 265, 5903-5909.[Abstract/Free Full Text]

Kleinman, H. K., McGarvey, M. L., Hassel, J. R., Star, V. L., Cannon, F., Laurie, G. W. and Martin, G. R (1986). Basement membrane complexes with biological activity. Biochemistry 25, 312-318.[Medline]

Koch, A. E., Harlow, L. A., Haines, G. K., Amento, E. P., Unemori, E. N., Wong, W. L., Pope, R. M. and Ferrara, N (1994). Vascular endothelial growth factor a cytokine modulating endothelial cell function in rheumatoid arthritis. J. Immunol 152, 4149-4156.[Abstract]

Luan, Y., Praul, C. A., Gay, C. V. and Leach, R. M (1996). Basic fibroblast growth factor: an autocrine growth factor for epiphyseal growth plate chondrocytes. J. Cell. Biochem 62, 372-382.[Medline]

Midy, V. and Plouet, J (1994). Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts. Biochem. Biophys. Res. Commun 199, 380-386.[Medline]

Millauer, B., Wizigmann-Voos, S., Schnurch, H., Martinez, R., Meller, N. P. H., Risau, W. and Ulrich, A (1993). High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72, 835-846.[Medline]

Moses, M. A., Sudhalter, J. and Langer, R (1990). Identification of an inhibitor of neovascularization from cartilage. Science 243, 1408-1410.

Moses, M. A., Sudhalter, J. and Langer, R (1992). Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes. J. Cell Biol 119, 475-482.[Abstract/Free Full Text]

Park, J. E., Keller, G. A. and Ferrara, N (1993). The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4, 1317-1326.[Abstract]

Pepper, M. S., Montesano, R., Vassalli, J. D. and Orci, L (1991). Chondrocytes inhibit endothelial sprout formation in vitro: evidence for involvement of a transforming growth factor-beta. J. Cell. Physiol 146, 170-179.[Medline]

Risau, W (1997). Mechanism of angiogenesis. Nature 386, 671-674.[Medline]

Ryan, A. M., Eppler, D. B., Hagler, K. E., Bruner, R. H., Thomford, P. J., Hall, R. L., Shopp, G. M. and O'Neill, C. A (1999). Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody. Toxicologic Pathol 27, 78-86.[Abstract/Free Full Text]

Schmidt, M. and Flamme, I (1998). The in vivo activity of vascular endothelial growth factor isoforms in the avian embryo. Growth Factors 15, 183-197.[Medline]

Terman, B. C., Dougher Vermazen, M., Carrion, M. E., Dimitrov, D., Armellino, D. C., Gospodarowicz, D. and Bohlen, P (1992). Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor. Biochem. Biophys. Res. Commun 187, 1579-1586.[Medline]

Towbin, H., Staehelin, T. and Gordon, J (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Nat. Acad. Sci.USA 78, 3039-3043.

Twal, W. O., Vasilatos-Younken, R., Gay, C. V. and Leach, R. M (1994). Isolation and localization of basic fibroblast growth factor immunoreactive substance in the epiphyseal growth plate. J. Bone Miner. Res 9, 1737-1744.[Medline]

Viglietto, G., Romano, A., Maglione, D., Rambaldi, M., Paoletti, I., Lago, C. T., Califano, D., Monaco, C., Mineo, A., Santelli, G., Manzo, G., Botti, G., Chiappetta, G. and Persico, M. G (1996). Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor. Oncogene 13, 577-587.[Medline]

Viglietto, G., Romano, A., Manzo, G., Chiappetta, G., Paoletti, I., Califano, D., Galati, M. G., Mauriello, V., Bruni, P., Lago, C. T., Fusco, A. and Persico, M. G (1997). Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization. Oncogene 15, 2687-2698.[Medline]

Vu, T. H., Shipley, J. M., Bergers, G., Bergers, J. E., Helms, J. A., Hanahan, D., Shapiro, S. D., Senior, R. M. and Werb, Z (1998). MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93, 411-422.[Medline]

Wang, D. S., Yamazaki, K, Nohtomi, K, Shizume, K., Ohsumi, K, Shibuya, M., Demura, H. and Sato, K (1996). Increase of vascular endothelial growth factor mRNA expression by 1, 25-dihydroxyvitamin D3 in human osteoblast like cells. J. Bone Miner. Res 11, 472-479.[Medline]

Wang, D. S., Miura, M., Demura, H. and Sato, K (1997). Anabolic effects of 1, 25-dihydroxyvitamin D3 on osteoblasts are enhanced by vascular endothelial growth factor produced by osteoblasts and by growth factors produced by endothelial cells. Endocrinology 138, 2953-2962.[Abstract/Free Full Text]

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				J. Dai and A.B.M. Rabie VEGF: an Essential Mediator of Both Angiogenesis and Endochondral Ossification J. Dent. Res., October 1, 2007; 86(10): 937 - 950. [Abstract] [Full Text] [PDF]

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				N. Ferrara Vascular Endothelial Growth Factor: Basic Science and Clinical Progress Endocr. Rev., August 1, 2004; 25(4): 581 - 611. [Abstract] [Full Text] [PDF]

				D. Pfander, T. Kobayashi, M. C. Knight, E. Zelzer, D. A. Chan, B. R. Olsen, A. J. Giaccia, R. S. Johnson, V. H. Haase, and E. Schipani Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development Development, May 15, 2004; 131(10): 2497 - 2508. [Abstract] [Full Text] [PDF]

				Y. Oike, Y. Ito, H. Maekawa, T. Morisada, Y. Kubota, M. Akao, T. Urano, K. Yasunaga, and T. Suda Angiopoietin-related growth factor (AGF) promotes angiogenesis Blood, May 15, 2004; 103(10): 3760 - 3765. [Abstract] [Full Text] [PDF]

				T. Pufe, A. Lemke, B. Kurz, W. Petersen, B. Tillmann, A. J. Grodzinsky, and R. Mentlein Mechanical Overload Induces VEGF in Cartilage Discs via Hypoxia-Inducible Factor Am. J. Pathol., January 1, 2004; 164(1): 185 - 192. [Abstract] [Full Text] [PDF]

				K. Henriksen, M. Karsdal, J.-M. Delaisse, and M. T. Engsig RANKL and Vascular Endothelial Growth Factor (VEGF) Induce Osteoclast Chemotaxis through an ERK1/2-dependent Mechanism J. Biol. Chem., December 5, 2003; 278(49): 48745 - 48753. [Abstract] [Full Text] [PDF]

				J.-K. Min, Y.-M. Kim, Y.-M. Kim, E.-C. Kim, Y. S. Gho, I.-J. Kang, S.-Y. Lee, Y.-Y. Kong, and Y.-G. Kwon Vascular Endothelial Growth Factor Up-regulates Expression of Receptor Activator of NF-{kappa}B (RANK) in Endothelial Cells: CONCOMITANT INCREASE OF ANGIOGENIC RESPONSES TO RANK LIGAND J. Biol. Chem., October 10, 2003; 278(41): 39548 - 39557. [Abstract] [Full Text] [PDF]

				Y.-B. Shui, X. Wang, J. S. Hu, S.-P. Wang, C. M. Garcia, J. D. Potts, Y. Sharma, and D. C. Beebe Vascular Endothelial Growth Factor Expression and Signaling in the Lens Invest. Ophthalmol. Vis. Sci., September 1, 2003; 44(9): 3911 - 3919. [Abstract] [Full Text] [PDF]

				S. Ivkovic, B. S. Yoon, S. N. Popoff, F. F. Safadi, D. E. Libuda, R. C. Stephenson, A. Daluiski, and K. M. Lyons Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development Development, June 15, 2003; 130(12): 2779 - 2791. [Abstract] [Full Text] [PDF]

				D. Pfander, T. Cramer, E. Schipani, and R. S. Johnson HIF-1{alpha} controls extracellular matrix synthesis by epiphyseal chondrocytes J. Cell Sci., May 1, 2003; 116(9): 1819 - 1826. [Abstract] [Full Text] [PDF]

				R. T. Ballock and R. J. O'Keefe The Biology of the Growth Plate J. Bone Joint Surg. Am., March 31, 2003; 85(4): 715 - 726. [Full Text] [PDF]

				E. Zelzer, W. McLean, Y.-S. Ng, N. Fukai, A. M. Reginato, S. Lovejoy, P. A. D'Amore, and B. R. Olsen Skeletal defects in VEGF120/120 mice reveal multiple roles for VEGF in skeletogenesis Development, March 6, 2003; 129(8): 1893 - 1904. [Abstract] [Full Text] [PDF]

				T Ushiyama, T Chano, K Inoue, and Y Matsusue Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids Ann Rheum Dis, February 1, 2003; 62(2): 108 - 112. [Abstract] [Full Text] [PDF]

				M. M. L. Deckers, R. L. van Bezooijen, G. van der Horst, J. Hoogendam, C. van der Bent, S. E. Papapoulos, and C. W. G. M. Lowik Bone Morphogenetic Proteins Stimulate Angiogenesis through Osteoblast-Derived Vascular Endothelial Growth Factor A Endocrinology, April 1, 2002; 143(4): 1545 - 1553. [Abstract] [Full Text] [PDF]

				N. Ferrara Role of vascular endothelial growth factor in regulation of physiological angiogenesis Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1358 - C1366. [Abstract] [Full Text] [PDF]

				B Zerega, L Camardella, S Cermelli, R Sala, R Cancedda, and F Descalzi Cancedda Avidin expression during chick chondrocyte and myoblast development in vitro and in vivo: regulation of cell proliferation J. Cell Sci., January 4, 2001; 114(8): 1473 - 1482. [Abstract] [PDF]

				J. Haigh, H. Gerber, N Ferrara, and E. Wagner Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state Development, January 4, 2000; 127(7): 1445 - 1453. [Abstract] [PDF]