Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Bastin, P.
	Articles by Gull, K.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Bastin, P.
	Articles by Gull, K.

Baccetti, B (1986). Evolutionary trends in sperm structure. Comp. Biochem. Physiol 85, 29-36.

Bastin, P., Bagherzadeh, A., Matthews, K. R. and Gull, K (1996). A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei. Mol. Biochem. Parasitol 77, 235-239.[Medline]

Bastin, P., Sherwin, T. and Gull, K (1998). Paraflagellar rod is essential to trypanosome motility. Nature 391, 548-.[Medline]

Beard, C. A., Saborio, J. L., Tewari, D., Krieglstein, K. G., Henschen, A. H. and ManningsJ. E (1992). Evidence for two distinct major protein components, PAR 1 and PAR 2, in the paraflagellar rod of Trypanosoma cruzi. J. Biol. Chem 267, 21656-21662.[Abstract/Free Full Text]

Cole, D., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C. and Rosenbaum, J (1998). Chlamydomonas kinesin II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons. J. Cell Biol 141, 993-1008.[Abstract/Free Full Text]

Deflorin, J., Rudolf, M. and Seebeck, T (1994). The major components of the paraflagellar rod of Trypanosoma brucei are two similar but distinct proteins which are encoded by two different gene loci. J. Biol. Chem 269, 28745-28751.[Abstract/Free Full Text]

Eid, J. and Sollner-Webb, B (1991). Stable integrative transformation of Trypanosoma brucei that occurs exclusively by homologous recombination. Proc. Nat. Acad. Sci. USA 88, 2118-2121.[Abstract/Free Full Text]

Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E. and Mello, C. G (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.[Medline]

Fok, A. K., Wang, H., Katayama, A. M., Aihira, S. and AllenR. D (1994). 22S axonemal dynein is preassembled and functional prior to being transported and attached on the axonemes. Cell Motil. Cytoskel 29, 215-224.[Medline]

Fouts, D. L., Stryker, G. A., Gorski, K. S., Miller, M. J., Nguyen, T. V., Whrightsman, R. A. and Manning, J. E (1998). Evidence for four major distinct protein components for the parflagellar rod of Trypanosoma cruzi. J. Biol. Chem 273, 21846-21855.[Abstract/Free Full Text]

Fowkes, M. E. and Mitchell, D. R (1998). The role of preasssembled cytoplasmic complexes in the assembly of flagellum dynein. Mol. Biol. Cell 9, 2337-2347.[Abstract/Free Full Text]

Gallo, J. M. and Schrevel, J (1985). Homologies between paraflagellar rod proteins from trypanosomes and euglenoids revealed by a monoclonal antibody. Eur. J. Cell Biol 36, 163-168.[Medline]

Johnson, K. A. and Rosenbaum, J. L (1992). Polarity of flagellar assembly in Chlamydomonas. J. Cell Biol 119, 1605-1611.[Abstract/Free Full Text]

King, S. M., Barbarese, E., Dillman, J. F., Patel-King, R. S., Carson, J. H. and Pfister, K. K (1996). Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved M r8, 000 light chain. J. Biol. Chem 271, 19358-19366.[Abstract/Free Full Text]

Kohl, L., Sherwin, T. and Gull, K (1999). Assembly of the paraflagellar rod and of the flagellum attachement zone complex in Trypanosoma brucei. J. Euk. Microbiol 46, 105-109.[Medline]

Kozminski, K. G., Johnson, K. A., Forscher, P. and Rosenbaum, J. L (1993). A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc. Nat. Acad. Sci. USA 90, 5519-5523.[Abstract/Free Full Text]

Kozminski, K. G., Beech, P. and Rosenbaum, J. L (1995). The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane. J. Cell Biol 131, 1517-1527.[Abstract/Free Full Text]

Lee, M. G. S. and Van der Ploeg, L. H. T (1990). Homologous recombination and stable transfection in the parasitic protozoan Trypanosoma brucei. Science 250, 1583-1587.[Abstract/Free Full Text]

Marszalek, J., Ruiz-Lozano, P., Roberts, E., Chien, K. R. and Goldstein, L. S. B (1999). Situs inversus and embryonic ciliary morphogenesis defectsin mouse mutants lacking the KIF3A subunit of kinesin-II. Proc. Nat. Acad. Sci. USA 96, 5043-5048.[Abstract/Free Full Text]

Moore, L., Santrich, C. and LeBowitz, J. H (1996). Stage-specific expression of the Leishmania mexicana paraflagellar rod protein PFR-2. Mol. Biochem. Parasitol 80, 125-135.[Medline]

Morris, R. L. and Scholey, J. M (1997). Heterotrimeric kinesin II is required for the assembly of motile 9+2 ciliary axonemes on sea urchin embryo. J. Cell Biol 138, 1009-1022.[Abstract/Free Full Text]

Ngo, H. M. and Bouck, G. B (1998). Heterogeneity and a coiled-coil prediction of trypanosomatid-like flagellar rod proteins in Euglena. J. Euk. Microbiol 45, 323-333.[Medline]

Ngo, H. M., Tschudi, C., Gull, K. and Ullu, E (1998). Double-stranded RNA induces mRNA degradation in Trypanosomabrucei. Proc. Nat. Acad. Sci. USA 95, 14687-14692.[Abstract/Free Full Text]

Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M. and Hirokawa, N (1998). Randomization of left-right asymmetry due to loss of a nodal cilia regenerating leftward flow of extraembryonic fluid in mice lacking KIF-3B motor protein. Cell 95, 829-837.[Medline]

Pazour, G. J., Wilkerson, C. G. and Witman, G. B (1998). A dynein light chain is essential for the retrograde particle movement of intraflagellar transport. J. Cell Biol 141, 979-992.[Abstract/Free Full Text]

Pazour G. J., Dickert, B. L. and Witman, G. B (1999). The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assembly. J. Cell Biol 144, 473-481.[Abstract/Free Full Text]

Piperno, G., Mead, K. and Henderson, S (1996). Inner dynein arms but not outer dynein arms require the activity of the kinesin homologue protein KHP1 Fla10 to reach the distal part of the flagella in Chlamydomonas. J. Cell Biol 133, 371-379.[Abstract/Free Full Text]

Porter, M. E., Bower, R., Knott, J. A., Byrd, P. and Dentler, W (1999). Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas. Mol. Biol. Cell 10, 693-712.[Abstract/Free Full Text]

Robinson, D. R. and Gull, K (1991). Basal body movements as a mechanism for mitochondrial genome segregation in the trypanosome cell cycle. Nature 352, 731-733.[Medline]

Rosenbaum, J. L., Moulder, J. E. and Ringo, D. L (1969). Flagellar elongation and shortening in Chlamydomonas. J. Cell Biol 41, 600-619.[Abstract/Free Full Text]

Rosenbaum, J. L., Cole, D. G. and Diener, D. R (1999). Intraflagellar transport: the eyes have it. J. Cell Biol 144, 385-388.[Free Full Text]

Russell, D. G. Newsham, R. J., Palmer, G. C. and Gull, K (1983). Structural and biochemical characterization of the paraflagellar rod structure of Crithidia fasciculata. Eur. J. Cell Biol 30, 137-143.[Medline]

Santrich, C., Moore, L., Bastin, P., Sherwin, T., Brokaw, C., Gull, K. and Lebowitz, J. H (1997). A motility function for the paraflagellar rod in Leishmania parasites revealed by PFR-2 gene knockouts. Mol. Biochem. Parasitol 90, 95-109.[Medline]

Schlaeppi, K., Deflorin, J. and Seebeck, T (1989). The major component of the paraflagellar rod of Trypanosoma brucei is a helical protein that is encoded by two identical, tandemly linked genes. J. Cell Biol 109, 1695-1709.[Abstract/Free Full Text]

Scott, V., Sherwin, T. and Gull, K (1997). -Tubulin in trypanosomes: molecular characterisation and localisation to multiple and diverse microtubule organising centres. J. Cell Sci 110, 157-168.[Abstract]

Shakir, M. A., Fukushige, T., Yasuda, H., Miwa, J. and Siddiqui, S. S (1993). C. elegansosm -3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein. Neuroreport 4, 891-894.[Medline]

Sherman, D. R., Janz, L., Hug., M. and Clayton, C. E (1991). Anatomy of the parp gene promoter of Trypanosoma brucei. EMBO J 10, 3379-3386.[Medline]

Sherwin, T., Schneider, A., Sasse, R., Seebeck, T. and Gull, K (1987). Distinct localisation and cell cycle dependence of COOH terminally tyrosinolated-tubulin in the microtubules of Trypanosoma brucei. J. Cell Biol 104, 439-446.[Abstract/Free Full Text]

Sherwin, T. and Gull, K (1989). Visualization of detyrosination along single microtubules reveals novel mechanisms of assembly during cytoskeletal duplication in trypanosomes. Cell 57, 211-221.[Medline]

Sherwin, T. and Gull, K (1989). The cell division cycle of Trypanosoma brucei brucei: timing of event markers and cytoskeleton modifications. Phil. Trans. R. Soc. London Ser. B 323, 575-588.

Tabish, M., Siddiqui, Z. K., Nishikawa, K. and Siddiqui, S. S (1995). Exclusive expression of C. elegans osm -3 kinesin gene in chemosensory neurons open to external environment. J. Mol. Biol 247, 377-389.[Medline]

ten Asbroek, A. L. M. A., Ouellette, M. and Borst, P (1990). Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei. Nature 348, 174-175.[Medline]

Vickerman, K (1962). The mechanism of cyclical development in trypanosomes of the Trypanosoma brucei subgroup: a hypothesis based on ultrastructural observations. Trans. R. Soc. Trop. Med. Hyg 56, 487-495.[Medline]

Witman, G. B (1975). The site of in vivo assembly of flagellar microtubules. Ann. NY Acad. Sci 253, 178-191.[Medline]

Woods, A., Sherwin, T., Sasse, R., MacRae, T. H., Baines, A. and Gull, K (1989). Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies. J. Cell Sci 93, 491-500.[Abstract/Free Full Text]

Woodward, R. and Gull, K (1990). Timing of nuclear and kinetoplast DNA replication and early morphological events in the cell cycle of Trypanosoma brucei. J. Cell Sci 95, 49-57.[Abstract/Free Full Text]

Woodward, R., Carden, M. J. and Gull, K (1994). Molecular characterisation of a novel, repetitive protein of the paraflagellar rod in Trypanosoma brucei. Mol. Biochem. Parasitol 67, 31-39.[Medline]

Woodward, R., Carden, M. J. and Gull, K (1995). Immunological characterization of cytoskeletal proteins associated with the basal body, axoneme and flagellum attachment zone of Trypanosoma brucei. Parasitology 111, 77-85.

Wu, Y. M., Haghighat, N. G and Ruben, L (1992). The predominant calcimedins from Trypanosoma brucei comprise a family of flagellar EF-hand calcium-binding proteins. Biochem J 287, 187-193.

Wu, Y. M., Deford, J., Benjamin, R., Lee, M. G. S. and Ruben, L (1994). The gene family of EF-hand calcium binding proteins from the flagellum of Trypanosoma brucei. Biochem J 304, 833-841.

This article has been cited by other articles:

S. Absalon, T. Blisnick, L. Kohl, G. Toutirais, G. Dore, D. Julkowska, A. Tavenet, and P. Bastin
Intraflagellar Transport and Functional Analysis of Genes Required for Flagellum Formation in Trypanosomes
Mol. Biol. Cell, March 1, 2008; 19(3): 929 - 944.
[Abstract] [Full Text] [PDF]

D. M. Baron, Z. P. Kabututu, and K. L. Hill
Stuck in reverse: loss of LC1 in Trypanosoma brucei disrupts outer dynein arms and leads to reverse flagellar beat and backward movement
J. Cell Sci., May 1, 2007; 120(9): 1513 - 1520.
[Abstract] [Full Text] [PDF]

M. Oberholzer, G. Marti, M. Baresic, S. Kunz, A. Hemphill, and T. Seebeck
The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence
FASEB J, March 1, 2007; 21(3): 720 - 731.
[Abstract] [Full Text] [PDF]

D. M. Baron, K. S. Ralston, Z. P. Kabututu, and K. L. Hill
Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella
J. Cell Sci., February 1, 2007; 120(3): 478 - 491.
[Abstract] [Full Text] [PDF]

C. Branche, L. Kohl, G. Toutirais, J. Buisson, J. Cosson, and P. Bastin
Conserved and specific functions of axoneme components in trypanosome motility
J. Cell Sci., August 15, 2006; 119(16): 3443 - 3455.
[Abstract] [Full Text] [PDF]

K. S. Ralston, A. G. Lerner, D. R. Diener, and K. L. Hill
Flagellar Motility Contributes to Cytokinesis in Trypanosoma brucei and Is Modulated by an Evolutionarily Conserved Dynein Regulatory System.
Eukaryot. Cell, April 1, 2006; 5(4): 696 - 711.
[Abstract] [Full Text] [PDF]

M. L. Ginger, E. S. Ngazoa, C. A. Pereira, T. J. Pullen, M. Kabiri, K. Becker, K. Gull, and D. Steverding
Intracellular Positioning of Isoforms Explains an Unusually Large Adenylate Kinase Gene Family in the Parasite Trypanosoma brucei
J. Biol. Chem., March 25, 2005; 280(12): 11781 - 11789.
[Abstract] [Full Text] [PDF]

C. Gadelha, B. Wickstead, W. de Souza, K. Gull, and N. Cunha-e-Silva
Cryptic Paraflagellar Rod in Endosymbiont-Containing Kinetoplastid Protozoa
Eukaryot. Cell, March 1, 2005; 4(3): 516 - 525.
[Abstract] [Full Text] [PDF]

D. Tull, J. E. Vince, J. M. Callaghan, T. Naderer, T. Spurck, G. I. McFadden, G. Currie, K. Ferguson, A. Bacic, and M. J. McConville
SMP-1, a Member of a New Family of Small Myristoylated Proteins in Kinetoplastid Parasites, Is Targeted to the Flagellum Membrane in Leishmania
Mol. Biol. Cell, November 1, 2004; 15(11): 4775 - 4786.
[Abstract] [Full Text] [PDF]

T. J. Pullen, M. L. Ginger, S. J. Gaskell, and K. Gull
Protein Targeting of an Unusual, Evolutionarily Conserved Adenylate Kinase to a Eukaryotic Flagellum
Mol. Biol. Cell, July 1, 2004; 15(7): 3257 - 3265.
[Abstract] [Full Text] [PDF]

M. Wiese, D. Kuhn, and C. G. Grunfelder
Protein Kinase Involved in Flagellar-Length Control
Eukaryot. Cell, August 1, 2003; 2(4): 769 - 777.
[Abstract] [Full Text] [PDF]

D. Escalier
New Insights into the Assembly of the Periaxonemal Structures in Mammalian Spermatozoa
Biol Reprod, August 1, 2003; 69(2): 373 - 378.
[Abstract] [Full Text] [PDF]

K. L. Hill
Biology and Mechanism of Trypanosome Cell Motility
Eukaryot. Cell, April 1, 2003; 2(2): 200 - 208.
[Full Text] [PDF]

N. R. Hutchings, J. E. Donelson, and K. L. Hill
Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes
J. Cell Biol., March 4, 2002; 156(5): 867 - 877.
[Abstract] [Full Text] [PDF]

K Ersfeld and K Gull
Targeting of cytoskeletal proteins to the flagellum of Trypanosoma brucei
J. Cell Sci., January 1, 2001; 114(1): 141 - 148.
[Abstract] [PDF]

P Bastin, K Ellis, L Kohl, and K Gull
Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system
J. Cell Sci., January 9, 2000; 113(18): 3321 - 3328.
[Abstract] [PDF]

N. R. Hutchings, J. E. Donelson, and K. L. Hill
Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes
J. Cell Biol., March 4, 2002; 156(5): 867 - 877.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Bastin, P.

Articles by Gull, K.

Search for Related Content

PubMed

PubMed Citation

Articles by Bastin, P.

Articles by Gull, K.

				D. M. Baron, Z. P. Kabututu, and K. L. Hill Stuck in reverse: loss of LC1 in Trypanosoma brucei disrupts outer dynein arms and leads to reverse flagellar beat and backward movement J. Cell Sci., May 1, 2007; 120(9): 1513 - 1520. [Abstract] [Full Text] [PDF]

				M. Oberholzer, G. Marti, M. Baresic, S. Kunz, A. Hemphill, and T. Seebeck The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence FASEB J, March 1, 2007; 21(3): 720 - 731. [Abstract] [Full Text] [PDF]

				D. M. Baron, K. S. Ralston, Z. P. Kabututu, and K. L. Hill Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella J. Cell Sci., February 1, 2007; 120(3): 478 - 491. [Abstract] [Full Text] [PDF]

				C. Branche, L. Kohl, G. Toutirais, J. Buisson, J. Cosson, and P. Bastin Conserved and specific functions of axoneme components in trypanosome motility J. Cell Sci., August 15, 2006; 119(16): 3443 - 3455. [Abstract] [Full Text] [PDF]

				K. S. Ralston, A. G. Lerner, D. R. Diener, and K. L. Hill Flagellar Motility Contributes to Cytokinesis in Trypanosoma brucei and Is Modulated by an Evolutionarily Conserved Dynein Regulatory System. Eukaryot. Cell, April 1, 2006; 5(4): 696 - 711. [Abstract] [Full Text] [PDF]

				M. L. Ginger, E. S. Ngazoa, C. A. Pereira, T. J. Pullen, M. Kabiri, K. Becker, K. Gull, and D. Steverding Intracellular Positioning of Isoforms Explains an Unusually Large Adenylate Kinase Gene Family in the Parasite Trypanosoma brucei J. Biol. Chem., March 25, 2005; 280(12): 11781 - 11789. [Abstract] [Full Text] [PDF]

				C. Gadelha, B. Wickstead, W. de Souza, K. Gull, and N. Cunha-e-Silva Cryptic Paraflagellar Rod in Endosymbiont-Containing Kinetoplastid Protozoa Eukaryot. Cell, March 1, 2005; 4(3): 516 - 525. [Abstract] [Full Text] [PDF]

				D. Tull, J. E. Vince, J. M. Callaghan, T. Naderer, T. Spurck, G. I. McFadden, G. Currie, K. Ferguson, A. Bacic, and M. J. McConville SMP-1, a Member of a New Family of Small Myristoylated Proteins in Kinetoplastid Parasites, Is Targeted to the Flagellum Membrane in Leishmania Mol. Biol. Cell, November 1, 2004; 15(11): 4775 - 4786. [Abstract] [Full Text] [PDF]

				T. J. Pullen, M. L. Ginger, S. J. Gaskell, and K. Gull Protein Targeting of an Unusual, Evolutionarily Conserved Adenylate Kinase to a Eukaryotic Flagellum Mol. Biol. Cell, July 1, 2004; 15(7): 3257 - 3265. [Abstract] [Full Text] [PDF]

				M. Wiese, D. Kuhn, and C. G. Grunfelder Protein Kinase Involved in Flagellar-Length Control Eukaryot. Cell, August 1, 2003; 2(4): 769 - 777. [Abstract] [Full Text] [PDF]

				D. Escalier New Insights into the Assembly of the Periaxonemal Structures in Mammalian Spermatozoa Biol Reprod, August 1, 2003; 69(2): 373 - 378. [Abstract] [Full Text] [PDF]

				K. L. Hill Biology and Mechanism of Trypanosome Cell Motility Eukaryot. Cell, April 1, 2003; 2(2): 200 - 208. [Full Text] [PDF]

				N. R. Hutchings, J. E. Donelson, and K. L. Hill Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes J. Cell Biol., March 4, 2002; 156(5): 867 - 877. [Abstract] [Full Text] [PDF]

				K Ersfeld and K Gull Targeting of cytoskeletal proteins to the flagellum of Trypanosoma brucei J. Cell Sci., January 1, 2001; 114(1): 141 - 148. [Abstract] [PDF]

				P Bastin, K Ellis, L Kohl, and K Gull Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system J. Cell Sci., January 9, 2000; 113(18): 3321 - 3328. [Abstract] [PDF]