Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Guay, J.
	Articles by Landry, J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Guay, J.
	Articles by Landry, J.

Ben-Levy, R., Leighton, I. A., Doza, Y. N., Attwood, P., Morrice, N., Marshall, C. J. and Cohen, P (1995). Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. EMBO J 14, 5920-5930.[Medline]

Benndorf, R., Hayess, K., Ryazantsev, S., Wieske, M., Behlke, J. and Lutsch, G (1994). Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. J. Biol. Chem 269, 20780-20784.[Abstract/Free Full Text]

Bird, P., Gething, M.-J. and Sambrook, J (1987). Translocation in yeast and mammalian cells: Not all signal sequences are functionally equivalent. J. Cell Biol 105, 2905-2914.[Abstract/Free Full Text]

Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E. and Gustin, M. C (1993). An osmosensing signal transduction pathway in yeast. Science 259, 1760-1763.[Abstract/Free Full Text]

Brunet, A., Pages, G. and Pouyssegur, J (1994). Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts. Oncogene 9, 3379-3387.[Medline]

Cai, H., Szeberenyi, J. and Cooper, G. M (1990). Effect of dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol. Cell Biol 10, 5314-5323.[Abstract/Free Full Text]

Chen, R. H., Sarnecki, C. and Blenis, J (1992). Nuclear localization and regulation of erk-and rsk-encoded protein kinases. Mol. Cell Biol 12, 915-927.[Abstract/Free Full Text]

Chung, J., Kuo, C. J., Crabtree, G. R. and Blenis, J (1992). Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69, 1227-1236.[Medline]

Cobb, M. H. and Goldsmith, E. J (1995). How MAP kinases are regulated. J. Biol. Chem 270, 14843-14846.[Free Full Text]

Cowley, S., Paterson, H., Kemp, P. and Marshall, C. J (1994). Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation. Cell 77, 841-852.[Medline]

Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R. and Lee, J. C (1995). SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364, 229-233.[Medline]

Davis, R. J (1994). MAPKs: new JNK expands the group. Trends Biochem. Sci 19, 470-473.[Medline]

Devary, Y., Gottlieb, R. A., Smeal, T. and Karin, M (1992). The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71, 1081-1091.[Medline]

Dubois, M. F. and Bensaude, O (1993). MAP kinase activation during heat shock in quiescent and exponentially growing cells. FEBS Lett 324, 191-195.[Medline]

Derijard, B., Hibi, M.., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R. J (1994). JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037.[Medline]

Derijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J. and Davis, R. J (1995). Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267, 682-684.[Abstract/Free Full Text]

Fialkow, L., Chan, C. K., Rotin, D., Grinstein, S. and Downey, G. P (1994). Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants. J. Biol. Chem 269, 31234-31242.[Abstract/Free Full Text]

Freshney, N. W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J. and Saklatvala, J (1994). Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78, 1039-1049.[Medline]

Gaestel, M., Schroder, W., Benndorf, R., Lippmann, C., Buchner, K., Hucho, F., Erdmann, V. A. and Bielka, H (1991). Identification of thephosphorylation sites of the murine small heat shock protein hsp25. J. Biol. Chem 266, 14721-14724.[Abstract/Free Full Text]

Guyton, K. Z., Liu, Y., Gorospe, M., Xu, Q. and Holbrook, N. J (1996). Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J. Biol. Chem 271, 4138-4142.[Abstract/Free Full Text]

Hall, A (1994). Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol 10, 31-54.

Han, J., Lee, J.-D., Bibbs, L. and Ulevitch, R. J (1994). A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808-811.[Abstract/Free Full Text]

Howe, L. R., Leevers, S. J., Gomez, N., Nakielny, S., Cohen, P. and Marshall, C. J (1992). Activation of the MAP kinase pathway by the protein kinase raf. Cell 71, 335-342.[Medline]

Hsiao, K. M., Chou, S. Y., Shih, S. J. and Ferrell, J. E., Jr (1994). Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo. Proc. Nat. Acad. Sci. USA 91, 5480-5484.[Abstract/Free Full Text]

Huot, J., Roy, G., Lambert, H., Chretien, P. and Landry, J (1991). Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27, 000 heat shock protein. Cancer Res 51, 5245-5252.[Abstract/Free Full Text]

Huot, J., Lambert, H., Lavoie, J. N., Guimond, A., Houle, F. and Landry, J (1995). Characterization of 45-kDa/54-kDa HSP27 kinase, a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27-kDa heat-shock protein HSP27. Eur. J. Biochem 227, 416-427.[Medline]

Huot, J., Houle, F., Spitz, D. R. and Landry, J (1996). HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress. Cancer Res 56, 273-279.[Abstract/Free Full Text]

Kato, K., Hasegawa, K., Goto, S. and Inaguma, Y (1994). Dissociation as a result of phosphorylation of an aggregated form of the small stress protein, hsp27. J. Biol. Chem 269, 11274-11278.[Abstract/Free Full Text]

Kolega, J., Janson, L. W. and Taylor, D. L (1991). The role of solation-contraction coupling in regulating stress fiber dynamics in nonmuscle cells. J. Cell Biol 114, 993-1003.[Abstract/Free Full Text]

Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J. and Woodgett, J. R (1994). The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160.[Medline]

Landry, J., Chretien, P., Lambert, H., Hickey, E. and Weber, L. A (1989). Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells. J. Cell Biol 109, 7-15.[Abstract/Free Full Text]

Landry, J., Lambert, H., Zhou, M., Lavoie, J. N., Hickey, E., Weber, L. A. and Anderson, C. W (1992). Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J. Biol. Chem 267, 794-803.[Abstract/Free Full Text]

Lavoie, J., Chretien, P. and Landry, J (1990). Sequence of the Chinese hamster small heat shock protein HSP27. Nucl. Acids Res 18, 1637-.[Free Full Text]

Lavoie, J. N., Gingras-Breton, G., Tanguay, R. M. and Landry, J (1993). Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization. J. Biol. Chem 268, 3420-3429.[Abstract/Free Full Text]

Lavoie, J. N., Hickey, E., Weber, L. A. and Landry, J (1993). Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27. J. Biol. Chem 268, 24210-24214.[Abstract/Free Full Text]

Lavoie, J. N., Lambert, H., Hickey, E., Weber, L. A. and Landry, J (1995). Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. Mol. Cell Biol 15, 505-516.[Abstract]

Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Heys, J. R., Landvatter, S. W., et al (1994). A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739-746.[Medline]

MacArthur, H. and Walter, G (1984). Monoclonal antibodies specific for the carboxy terminus of simian virus 40 large T antigen. J. Virol 52, 483-491.[Abstract/Free Full Text]

Mansour, S. J., Matten, W. T., Hermann, A. S., Candia, J. M., Rong, S., Fukasawa, K., Vande Woude, G. F. and Ahn, N. G (1994). Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265, 966-970.[Abstract/Free Full Text]

Marshall, C. J (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.[Medline]

Matsuda, S., Kawasaki, H., Moriguchi, T., Gotoh, Y. and Nishida, E (1995). Activation of protein kinase cascades by osmotic shock. J. Biol. Chem 270, 12781-12786.[Abstract/Free Full Text]

McLaughlin, M. M., Kumar, S., McDonnell, P. C., Van Horn, S., Lee, J. C.,Livi, G. P. and Young, P. R (1996). Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J. Biol. Chem 271, 8488-8492.[Abstract/Free Full Text]

Mehlen, P., Preville, X., Chareyron, P., Briolay, J., Klemenz, R. and Arrigo, A. P (1995). Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF-and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts. J. Immunol 154, 363-374.[Abstract]

Meloche, S., Pages, G. and Pouyssegur, J (1992). Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated kinase, p44mapk. Mol. Cell Biol 3, 63-71.

Miron, T., Vancompernolle, K., Vandekerckhove, J., Wilchek, M. and Geiger, B (1991). A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J. Cell Biol 114, 255-261.[Abstract/Free Full Text]

Nobes, C. D. and Hall, A (1995). Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.[Medline]

Pages, G., Lenormand, P., L'Allemain, G., Chambard, J. C., Meloche, S. and Pouyssegur, J (1993). Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc. Nat. Acad. Sci. USA 90, 8319-8323.[Abstract/Free Full Text]

Pantaloni, D. and Carlier, M.-F (1993). How profilin promotes actin filament assembly in the presence of thymosin B4. Cell 75, 1007-1014.[Medline]

Radler-Pohl, A., Sachsenmaier, C., Gebel, S., Auer, H. P., Bruder, J. T., Rapp, U., Angel, P., Rahmsdorf, H. J. and Herrlich, P (1993). UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J 12, 1005-1012.[Medline]

Rao, V. N. and Reddy, E. S (1994). elk-1 proteins interact with MAP kinases. Oncogene 9, 1855-1860.[Medline]

Ridley, A. J. and Hall, A (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.[Medline]

Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.[Medline]

Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T. and Nebreda, A. R. ( (1994). A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027-1037.[Medline]

Sachsenmaier, C., Radler-Pohl, A., Zinck, R., Nordheim, A., Herrlich, P. and Rahmsdorf, H. J (1994). Involvement of growth factor receptors in the mammalian UVC response. Cell 78, 963-972.[Medline]

Saklatvala, J., Rawlinson, L., Waller, R. J., Sarsfield, S., Lee, J. C., Morton, L. F., Barnes, M. J. and Farndale, R. W (1996). Role of p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue. J. Biol. Chem 271, 6586-6589.[Abstract/Free Full Text]

Sampath, P. and Pollard, T. D (1991). Effects of cytochalasin, phalloidin, and pH on the elongation of actin filaments. Biochemistry 30, 1973-1980.[Medline]

Shih, C. and Weinberg, R. A (1982). Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell 29, 161-169.[Medline]

Stevenson, M. A., Pollock, S. S., Coleman, C. N. and Calderwood, S. K (1994). X-Irradiation, phorbol esters, and H2O2stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates. Cancer Res 54, 12-15.[Abstract/Free Full Text]

Stokoe, D., Campbell, D. G., Nakielny, S., Hidaka, H., Leevers, S. J., Marshall, C. and Cohen, P (1992). MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J 11, 3985-3994.[Medline]

Stokoe, D., Engel, K., Campbell, D. G., Cohen, P. and Gaestel, M (1992). Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett 313, 307-313.[Medline]

Terada, Y., Tomita, K., Homma, M. K., Nonoguchi, H., Yang, T., Yamada, T., Yuasa, Y., Krebs, E. G., Sasaki, S. and Marumo, F (1994). Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells. J. Biol. Chem 269, 31296-31301.[Abstract/Free Full Text]

Waskiewicz, A. J. and Cooper, J. A (1995). Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Opin. Cell Biol 7, 798-805.[Medline]

Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J. and Greenberg, M. E (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.[Abstract/Free Full Text]

Yahara, I., Harada, F., Sekita, S., Yoshihira, K. and Natori, S (1982). Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro. J. Cell Biol 92, 69-78.[Abstract/Free Full Text]

Zhang, S., Han, J., Sells, M. A., Chernoff, J., Knaus, U. G., Ulevitch, R. J. and Bokoch, G. M (1995). Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem 270, 23934-23936.[Abstract/Free Full Text]

Zhou, M., Lambert, H. and Landry, J (1993). Transient activation of a distinct serine protein kinase is responsible for 27-kDa heat shock protein phosphorylation in mitogen-stimulated and heat-shocked cells. J. Biol. Chem 268, 35-43.[Abstract/Free Full Text]

Zigmond, S. H (1996). Signal transduction and actin filament organization. Curr. Opin. Cell Biol 8, 66-73.[Medline]

Zu, Y.-L., Wu, F., Gilchrist, A., Ai, Y., Labadia, M. E. and Huang, C. K (1994). The primary structure of a human MAP kinase activated protein kinase 2. Biochem. Biophys. Res. Commun 200, 1118-1124.[Medline]

Zu, Y.-L., Ai, Y. and Huang, C. K (1995). Characterization of an autoinhibitory domain in human mitogen-activated protein kinase-activated protein kinase 2. J. Biol. Chem 270, 202-206.[Abstract/Free Full Text]

This article has been cited by other articles:

A. L. Yu, R. Fuchshofer, M. Birke, A. Kampik, H. Bloemendal, and U. Welge-Lussen
Oxidative Stress and TGF-{beta}2 Increase Heat Shock Protein 27 Expression in Human Optic Nerve Head Astrocytes
Invest. Ophthalmol. Vis. Sci., December 1, 2008; 49(12): 5403 - 5411.
[Abstract] [Full Text] [PDF]

P. Berkowitz, M. Chua, Z. Liu, L. A. Diaz, and D. S. Rubenstein
Autoantibodies in the Autoimmune Disease Pemphigus Foliaceus Induce Blistering via p38 Mitogen-Activated Protein Kinase-Dependent Signaling in the Skin
Am. J. Pathol., December 1, 2008; 173(6): 1628 - 1636.
[Abstract] [Full Text] [PDF]

S. Chaudhuri and P. G. Smith
Cyclic Strain-Induced HSP27 Phosphorylation Modulates Actin Filaments in Airway Smooth Muscle Cells
Am. J. Respir. Cell Mol. Biol., September 1, 2008; 39(3): 270 - 278.
[Abstract] [Full Text] [PDF]

G.-X. Shi, L. Jin, and D. A. Andres
Pituitary Adenylate Cyclase-Activating Polypeptide 38-Mediated Rin Activation Requires Src and Contributes to the Regulation of Hsp27 Signaling during Neuronal Differentiation
Mol. Cell. Biol., August 15, 2008; 28(16): 4940 - 4951.
[Abstract] [Full Text] [PDF]

D.-S. Jung, J. J. Li, S.-J. Kwak, S. H. Lee, J. Park, Y. S. Song, T.-H. Yoo, S. H. Han, J. E. Lee, D. K. Kim, et al.
FR167653 inhibits fibronectin expression and apoptosis in diabetic glomeruli and in high-glucose-stimulated mesangial cells
Am J Physiol Renal Physiol, August 1, 2008; 295(2): F595 - F604.
[Abstract] [Full Text] [PDF]

K. Namekata, C. Harada, K. Kohyama, Y. Matsumoto, and T. Harada
Interleukin-1 Stimulates Glutamate Uptake in Glial Cells by Accelerating Membrane Trafficking of Na+/K+-ATPase via Actin Depolymerization
Mol. Cell. Biol., May 15, 2008; 28(10): 3273 - 3280.
[Abstract] [Full Text] [PDF]

J. Guo, R. Ananthakrishnan, W. Qu, Y. Lu, N. Reiniger, S. Zeng, W. Ma, R. Rosario, S. F. Yan, R. Ramasamy, et al.
RAGE Mediates Podocyte Injury in Adriamycin-induced Glomerulosclerosis
J. Am. Soc. Nephrol., May 1, 2008; 19(5): 961 - 972.
[Abstract] [Full Text] [PDF]

X. Zheng, L. Hong, L. Shi, J. Guo, Z. Sun, and J. Zhou
Proteomics Analysis of Host Cells Infected with Infectious Bursal Disease Virus
Mol. Cell. Proteomics, March 1, 2008; 7(3): 612 - 625.
[Abstract] [Full Text] [PDF]

C. Csortos, I. Kolosova, and A. D. Verin
Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family
Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L843 - L854.
[Abstract] [Full Text] [PDF]

P. J. Nadeau, S. J. Charette, M. B. Toledano, and J. Landry
Disulfide Bond-mediated Multimerization of Ask1 and Its Reduction by Thioredoxin-1 Regulate H2O2-induced c-Jun NH2-terminal Kinase Activation and Apoptosis
Mol. Biol. Cell, October 1, 2007; 18(10): 3903 - 3913.
[Abstract] [Full Text] [PDF]

W. Huang, J. B. Fileta, T. Filippopoulos, A. Ray, A. Dobberfuhl, and C. L. Grosskreutz
Hsp27 Phosphorylation in Experimental Glaucoma
Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4129 - 4135.
[Abstract] [Full Text] [PDF]

C. Gaitanaki, T. Kalpachidou, I.-K. S. Aggeli, P. Papazafiri, and I. Beis
CoCl2 induces protective events via the p38-MAPK signalling pathway and ANP in the perfused amphibian heart
J. Exp. Biol., July 1, 2007; 210(13): 2267 - 2277.
[Abstract] [Full Text] [PDF]

F. Kawano, Y. Matsuoka, Y. Oke, Y. Higo, M. Terada, X. D. Wang, N. Nakai, H. Fukuda, S. Imajoh-Ohmi, and Y. Ohira
Role(s) of nucleoli and phosphorylation of ribosomal protein S6 and/or HSP27 in the regulation of muscle mass
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C35 - C44.
[Abstract] [Full Text] [PDF]

K. A. Huey, G. E. McCall, H. Zhong, and R. R. Roy
Modulation of HSP25 and TNF-{alpha} during the early stages of functional overload of a rat slow and fast muscle
J Appl Physiol, June 1, 2007; 102(6): 2307 - 2314.
[Abstract] [Full Text] [PDF]

J.-T. Hsu, Y.-C. Hsieh, W. H. Kan, J. G. Chen, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry
Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2982 - H2987.
[Abstract] [Full Text] [PDF]

A. Shamaei-Tousi, J. P. Halcox, and B. Henderson
Stressing the obvious? Cell stress and cell stress proteins in cardiovascular disease
Cardiovasc Res, April 1, 2007; 74(1): 19 - 28.
[Abstract] [Full Text] [PDF]

K. A. Alford, S. Glennie, B. R. Turrell, L. Rawlinson, J. Saklatvala, and J. L. E. Dean
Heat Shock Protein 27 Functions in Inflammatory Gene Expression and Transforming Growth Factor-beta-activated Kinase-1 (TAK1)-mediated Signaling
J. Biol. Chem., March 2, 2007; 282(9): 6232 - 6241.
[Abstract] [Full Text] [PDF]

S.-W. Park, J.-H. Yi, G. Miranpuri, I. Satriotomo, K. Bowen, D. K. Resnick, and R. Vemuganti
Thiazolidinedione Class of Peroxisome Proliferator-Activated Receptor {gamma} Agonists Prevents Neuronal Damage, Motor Dysfunction, Myelin Loss, Neuropathic Pain, and Inflammation after Spinal Cord Injury in Adult Rats
J. Pharmacol. Exp. Ther., March 1, 2007; 320(3): 1002 - 1012.
[Abstract] [Full Text] [PDF]

C. Gaitanaki, M. Pliatska, K. Stathopoulou, and I. Beis
Cu2+ and acute thermal stress induce protective events via the p38-MAPK signalling pathway in the perfused Rana ridibunda heart
J. Exp. Biol., February 1, 2007; 210(3): 438 - 446.
[Abstract] [Full Text] [PDF]

E. Schmitt, M. Gehrmann, M. Brunet, G. Multhoff, and C. Garrido
Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy
J. Leukoc. Biol., January 1, 2007; 81(1): 15 - 27.
[Abstract] [Full Text] [PDF]

M. Kamada, A. So, M. Muramaki, P. Rocchi, E. Beraldi, and M. Gleave
Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells
Mol. Cancer Ther., January 1, 2007; 6(1): 299 - 308.
[Abstract] [Full Text] [PDF]

P. Rafiee, M. E. Theriot, V. M. Nelson, J. Heidemann, Y. Kanaa, S. A. Horowitz, A. Rogaczewski, C. P. Johnson, I. Ali, R. Shaker, et al.
Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27
Am J Physiol Cell Physiol, November 1, 2006; 291(5): C931 - C945.
[Abstract] [Full Text] [PDF]

S. Somara and K. N. Bitar
Phosphorylated HSP27 modulates the association of phosphorylated caldesmon with tropomyosin in colonic smooth muscle
Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G630 - G639.
[Abstract] [Full Text] [PDF]

J. J. Saris, P. A.C. 't Hoen, I. M. Garrelds, D. H.W. Dekkers, J. T. den Dunnen, J. M.J. Lamers, and A.H. Jan Danser
Prorenin Induces Intracellular Signaling in Cardiomyocytes Independently of Angiotensin II
Hypertension, October 1, 2006; 48(4): 564 - 571.
[Abstract] [Full Text] [PDF]

A. Vertii, C. Hakim, A. Kotlyarov, and M. Gaestel
Analysis of Properties of Small Heat Shock Protein Hsp25 in MAPK-activated Protein Kinase 2 (MK2)-deficient Cells: MK2-DEPENDENT INSOLUBILIZATION OF Hsp25 OLIGOMERS CORRELATES WITH SUSCEPTIBILITY TO STRESS
J. Biol. Chem., September 15, 2006; 281(37): 26966 - 26975.
[Abstract] [Full Text] [PDF]

S. Li, H. Tanaka, H. H. Wang, S. Yoshiyama, H. Kumagai, A. Nakamura, D. L. Brown, S. E. Thatcher, G. L. Wright, and K. Kohama
Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation
Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1262 - H1272.
[Abstract] [Full Text] [PDF]

P. Berkowitz, P. Hu, S. Warren, Z. Liu, L. A. Diaz, and D. S. Rubenstein
p38MAPK inhibition prevents disease in pemphigus vulgaris mice
PNAS, August 22, 2006; 103(34): 12855 - 12860.
[Abstract] [Full Text] [PDF]

Z. Xiao, J. Xue, T. J. Sowin, and H. Zhang
Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy.
Mol. Cancer Ther., August 1, 2006; 5(8): 1935 - 1943.
[Abstract] [Full Text] [PDF]

K. Parhar, K. A. Baer, K. Parker, and M. J. Ropeleski
Short-chain fatty acid mediated phosphorylation of heat shock protein 25: effects on camptothecin-induced apoptosis
Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G178 - G188.
[Abstract] [Full Text] [PDF]

H. Wei, W. Campbell, and R. S. Vander Heide
Heat shock-induced cardioprotection activates cytoskeletal-based cell survival pathways
Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H638 - H647.
[Abstract] [Full Text] [PDF]

C. Jomary, J. Cullen, and S. E. Jones
Inactivation of the Akt Survival Pathway during Photoreceptor Apoptosis in the Retinal Degeneration Mouse.
Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1620 - 1629.
[Abstract] [Full Text] [PDF]

J. Segarra, L. Balenci, T. Drenth, F. Maina, and F. Lamballe
Combined Signaling through ERK, PI3K/AKT, and RAC1/p38 Is Required for Met-triggered Cortical Neuron Migration
J. Biol. Chem., February 24, 2006; 281(8): 4771 - 4778.
[Abstract] [Full Text] [PDF]

K. A. Huey
Regulation of HSP25 expression and phosphorylation in functionally overloaded rat plantaris and soleus muscles
J Appl Physiol, February 1, 2006; 100(2): 451 - 456.
[Abstract] [Full Text] [PDF]

K. D. Shin, M.-Y. Lee, D.-S. Shin, S. Lee, K.-H. Son, S. Koh, Y.-K. Paik, B.-M. Kwon, and D. C. Han
Blocking Tumor Cell Migration and Invasion with Biphenyl Isoxazole Derivative KRIBB3, a Synthetic Molecule That Inhibits Hsp27 Phosphorylation
J. Biol. Chem., December 16, 2005; 280(50): 41439 - 41448.
[Abstract] [Full Text] [PDF]

G. A. Knock, A. S. De Silva, V. A. Snetkov, R. Siow, G. D. Thomas, M. Shiraishi, M. P. Walsh, J. P. T. Ward, and P. I. Aaronson
Modulation of PGF2{alpha}- and hypoxia-induced contraction of rat intrapulmonary artery by p38 MAPK inhibition: a nitric oxide-dependent mechanism
Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1039 - L1048.
[Abstract] [Full Text] [PDF]

T. Okada, H. Otani, Y. Wu, S. Kyoi, C. Enoki, H. Fujiwara, T. Sumida, R. Hattori, and H. Imamura
Role of F-actin organization in p38 MAP kinase-mediated apoptosis and necrosis in neonatal rat cardiomyocytes subjected to simulated ischemia and reoxygenation
Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2310 - H2318.
[Abstract] [Full Text] [PDF]

T. Davis, D. M. Baird, M. F. Haughton, C. J. Jones, and D. Kipling
Prevention of Accelerated Cell Aging in Werner Syndrome Using a p38 Mitogen-Activated Protein Kinase Inhibitor
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2005; 60(11): 1386 - 1393.
[Abstract] [Full Text] [PDF]

M. Koshikawa, M. Mukoyama, K. Mori, T. Suganami, K. Sawai, T. Yoshioka, T. Nagae, H. Yokoi, H. Kawachi, F. Shimizu, et al.
Role of p38 Mitogen-Activated Protein Kinase Activation in Podocyte Injury and Proteinuria in Experimental Nephrotic Syndrome
J. Am. Soc. Nephrol., September 1, 2005; 16(9): 2690 - 2701.
[Abstract] [Full Text] [PDF]

S. S. An, C. M. Pennella, A. Gonnabathula, J. Chen, N. Wang, M. Gaestel, P. M. Hassoun, J. J. Fredberg, and U. S. Kayyali
Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways
Am J Physiol Cell Physiol, September 1, 2005; 289(3): C521 - C530.
[Abstract] [Full Text] [PDF]

A.I. De Souza, R. Wait, A.G. Mitchell, N.R. Banner, M.J. Dunn, and M.L. Rose
Heat Shock Protein 27 Is Associated With Freedom From Graft Vasculopathy After Human Cardiac Transplantation
Circ. Res., July 22, 2005; 97(2): 192 - 198.
[Abstract] [Full Text] [PDF]

F.-Q. Yu, C.-S. Han, W. Yang, X. Jin, Z.-Y. Hu, and Y.-X. Liu
Activation of the p38 MAPK pathway by follicle-stimulating hormone regulates steroidogenesis in granulosa cells differentially
J. Endocrinol., July 1, 2005; 186(1): 85 - 96.
[Abstract] [Full Text] [PDF]

P. Madan, M. D Calder, and A. J Watson
Mitogen-activated protein kinase (MAPK) blockade of bovine preimplantation embryogenesis requires inhibition of both p38 and extracellular signal-regulated kinase (ERK) pathways
Reproduction, July 1, 2005; 130(1): 41 - 51.
[Abstract] [Full Text] [PDF]

A. A. Birukova, K. G. Birukov, B. Gorshkov, F. Liu, J. G. N. Garcia, and A. D. Verin
MAP kinases in lung endothelial permeability induced by microtubule disassembly
Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L75 - L84.
[Abstract] [Full Text] [PDF]

P. Berkowitz, P. Hu, Z. Liu, L. A. Diaz, J. J. Enghild, M. P. Chua, and D. S. Rubenstein
Desmosome Signaling: INHIBITION OF p38MAPK PREVENTS PEMPHIGUS VULGARIS IgG-INDUCED CYTOSKELETON REORGANIZATION
J. Biol. Chem., June 24, 2005; 280(25): 23778 - 23784.
[Abstract] [Full Text] [PDF]

Y.-J. Lee, D.-H. Lee, C.-K. Cho, S. Bae, G.-J. Jhon, S.-J. Lee, J.-W. Soh, and Y.-S. Lee
HSP25 Inhibits Protein Kinase C{delta}-mediated Cell Death through Direct Interaction
J. Biol. Chem., May 6, 2005; 280(18): 18108 - 18119.
[Abstract] [Full Text] [PDF]

C. Dubroca, D. You, B. I. Levy, L. Loufrani, and D. Henrion
Involvement of RhoA/Rho Kinase Pathway in Myogenic Tone in the Rabbit Facial Vein
Hypertension, May 1, 2005; 45(5): 974 - 979.
[Abstract] [Full Text] [PDF]

				P. Berkowitz, M. Chua, Z. Liu, L. A. Diaz, and D. S. Rubenstein Autoantibodies in the Autoimmune Disease Pemphigus Foliaceus Induce Blistering via p38 Mitogen-Activated Protein Kinase-Dependent Signaling in the Skin Am. J. Pathol., December 1, 2008; 173(6): 1628 - 1636. [Abstract] [Full Text] [PDF]

				S. Chaudhuri and P. G. Smith Cyclic Strain-Induced HSP27 Phosphorylation Modulates Actin Filaments in Airway Smooth Muscle Cells Am. J. Respir. Cell Mol. Biol., September 1, 2008; 39(3): 270 - 278. [Abstract] [Full Text] [PDF]

				G.-X. Shi, L. Jin, and D. A. Andres Pituitary Adenylate Cyclase-Activating Polypeptide 38-Mediated Rin Activation Requires Src and Contributes to the Regulation of Hsp27 Signaling during Neuronal Differentiation Mol. Cell. Biol., August 15, 2008; 28(16): 4940 - 4951. [Abstract] [Full Text] [PDF]

				D.-S. Jung, J. J. Li, S.-J. Kwak, S. H. Lee, J. Park, Y. S. Song, T.-H. Yoo, S. H. Han, J. E. Lee, D. K. Kim, et al. FR167653 inhibits fibronectin expression and apoptosis in diabetic glomeruli and in high-glucose-stimulated mesangial cells Am J Physiol Renal Physiol, August 1, 2008; 295(2): F595 - F604. [Abstract] [Full Text] [PDF]

				K. Namekata, C. Harada, K. Kohyama, Y. Matsumoto, and T. Harada Interleukin-1 Stimulates Glutamate Uptake in Glial Cells by Accelerating Membrane Trafficking of Na+/K+-ATPase via Actin Depolymerization Mol. Cell. Biol., May 15, 2008; 28(10): 3273 - 3280. [Abstract] [Full Text] [PDF]

				J. Guo, R. Ananthakrishnan, W. Qu, Y. Lu, N. Reiniger, S. Zeng, W. Ma, R. Rosario, S. F. Yan, R. Ramasamy, et al. RAGE Mediates Podocyte Injury in Adriamycin-induced Glomerulosclerosis J. Am. Soc. Nephrol., May 1, 2008; 19(5): 961 - 972. [Abstract] [Full Text] [PDF]

				X. Zheng, L. Hong, L. Shi, J. Guo, Z. Sun, and J. Zhou Proteomics Analysis of Host Cells Infected with Infectious Bursal Disease Virus Mol. Cell. Proteomics, March 1, 2008; 7(3): 612 - 625. [Abstract] [Full Text] [PDF]

				C. Csortos, I. Kolosova, and A. D. Verin Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L843 - L854. [Abstract] [Full Text] [PDF]

				P. J. Nadeau, S. J. Charette, M. B. Toledano, and J. Landry Disulfide Bond-mediated Multimerization of Ask1 and Its Reduction by Thioredoxin-1 Regulate H2O2-induced c-Jun NH2-terminal Kinase Activation and Apoptosis Mol. Biol. Cell, October 1, 2007; 18(10): 3903 - 3913. [Abstract] [Full Text] [PDF]

				W. Huang, J. B. Fileta, T. Filippopoulos, A. Ray, A. Dobberfuhl, and C. L. Grosskreutz Hsp27 Phosphorylation in Experimental Glaucoma Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4129 - 4135. [Abstract] [Full Text] [PDF]

				C. Gaitanaki, T. Kalpachidou, I.-K. S. Aggeli, P. Papazafiri, and I. Beis CoCl2 induces protective events via the p38-MAPK signalling pathway and ANP in the perfused amphibian heart J. Exp. Biol., July 1, 2007; 210(13): 2267 - 2277. [Abstract] [Full Text] [PDF]

				F. Kawano, Y. Matsuoka, Y. Oke, Y. Higo, M. Terada, X. D. Wang, N. Nakai, H. Fukuda, S. Imajoh-Ohmi, and Y. Ohira Role(s) of nucleoli and phosphorylation of ribosomal protein S6 and/or HSP27 in the regulation of muscle mass Am J Physiol Cell Physiol, July 1, 2007; 293(1): C35 - C44. [Abstract] [Full Text] [PDF]

				K. A. Huey, G. E. McCall, H. Zhong, and R. R. Roy Modulation of HSP25 and TNF-{alpha} during the early stages of functional overload of a rat slow and fast muscle J Appl Physiol, June 1, 2007; 102(6): 2307 - 2314. [Abstract] [Full Text] [PDF]

				J.-T. Hsu, Y.-C. Hsieh, W. H. Kan, J. G. Chen, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2982 - H2987. [Abstract] [Full Text] [PDF]

				A. Shamaei-Tousi, J. P. Halcox, and B. Henderson Stressing the obvious? Cell stress and cell stress proteins in cardiovascular disease Cardiovasc Res, April 1, 2007; 74(1): 19 - 28. [Abstract] [Full Text] [PDF]

				K. A. Alford, S. Glennie, B. R. Turrell, L. Rawlinson, J. Saklatvala, and J. L. E. Dean Heat Shock Protein 27 Functions in Inflammatory Gene Expression and Transforming Growth Factor-beta-activated Kinase-1 (TAK1)-mediated Signaling J. Biol. Chem., March 2, 2007; 282(9): 6232 - 6241. [Abstract] [Full Text] [PDF]

				S.-W. Park, J.-H. Yi, G. Miranpuri, I. Satriotomo, K. Bowen, D. K. Resnick, and R. Vemuganti Thiazolidinedione Class of Peroxisome Proliferator-Activated Receptor {gamma} Agonists Prevents Neuronal Damage, Motor Dysfunction, Myelin Loss, Neuropathic Pain, and Inflammation after Spinal Cord Injury in Adult Rats J. Pharmacol. Exp. Ther., March 1, 2007; 320(3): 1002 - 1012. [Abstract] [Full Text] [PDF]

				C. Gaitanaki, M. Pliatska, K. Stathopoulou, and I. Beis Cu2+ and acute thermal stress induce protective events via the p38-MAPK signalling pathway in the perfused Rana ridibunda heart J. Exp. Biol., February 1, 2007; 210(3): 438 - 446. [Abstract] [Full Text] [PDF]

				E. Schmitt, M. Gehrmann, M. Brunet, G. Multhoff, and C. Garrido Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy J. Leukoc. Biol., January 1, 2007; 81(1): 15 - 27. [Abstract] [Full Text] [PDF]

				M. Kamada, A. So, M. Muramaki, P. Rocchi, E. Beraldi, and M. Gleave Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells Mol. Cancer Ther., January 1, 2007; 6(1): 299 - 308. [Abstract] [Full Text] [PDF]

				P. Rafiee, M. E. Theriot, V. M. Nelson, J. Heidemann, Y. Kanaa, S. A. Horowitz, A. Rogaczewski, C. P. Johnson, I. Ali, R. Shaker, et al. Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27 Am J Physiol Cell Physiol, November 1, 2006; 291(5): C931 - C945. [Abstract] [Full Text] [PDF]

				S. Somara and K. N. Bitar Phosphorylated HSP27 modulates the association of phosphorylated caldesmon with tropomyosin in colonic smooth muscle Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G630 - G639. [Abstract] [Full Text] [PDF]

				J. J. Saris, P. A.C. 't Hoen, I. M. Garrelds, D. H.W. Dekkers, J. T. den Dunnen, J. M.J. Lamers, and A.H. Jan Danser Prorenin Induces Intracellular Signaling in Cardiomyocytes Independently of Angiotensin II Hypertension, October 1, 2006; 48(4): 564 - 571. [Abstract] [Full Text] [PDF]

				A. Vertii, C. Hakim, A. Kotlyarov, and M. Gaestel Analysis of Properties of Small Heat Shock Protein Hsp25 in MAPK-activated Protein Kinase 2 (MK2)-deficient Cells: MK2-DEPENDENT INSOLUBILIZATION OF Hsp25 OLIGOMERS CORRELATES WITH SUSCEPTIBILITY TO STRESS J. Biol. Chem., September 15, 2006; 281(37): 26966 - 26975. [Abstract] [Full Text] [PDF]

				S. Li, H. Tanaka, H. H. Wang, S. Yoshiyama, H. Kumagai, A. Nakamura, D. L. Brown, S. E. Thatcher, G. L. Wright, and K. Kohama Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1262 - H1272. [Abstract] [Full Text] [PDF]

				P. Berkowitz, P. Hu, S. Warren, Z. Liu, L. A. Diaz, and D. S. Rubenstein p38MAPK inhibition prevents disease in pemphigus vulgaris mice PNAS, August 22, 2006; 103(34): 12855 - 12860. [Abstract] [Full Text] [PDF]

				Z. Xiao, J. Xue, T. J. Sowin, and H. Zhang Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy. Mol. Cancer Ther., August 1, 2006; 5(8): 1935 - 1943. [Abstract] [Full Text] [PDF]

				K. Parhar, K. A. Baer, K. Parker, and M. J. Ropeleski Short-chain fatty acid mediated phosphorylation of heat shock protein 25: effects on camptothecin-induced apoptosis Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G178 - G188. [Abstract] [Full Text] [PDF]

				H. Wei, W. Campbell, and R. S. Vander Heide Heat shock-induced cardioprotection activates cytoskeletal-based cell survival pathways Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H638 - H647. [Abstract] [Full Text] [PDF]

				C. Jomary, J. Cullen, and S. E. Jones Inactivation of the Akt Survival Pathway during Photoreceptor Apoptosis in the Retinal Degeneration Mouse. Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1620 - 1629. [Abstract] [Full Text] [PDF]