Modulation of tight junction structure in blood-brain barrier endothelial cells. Effects of tissue culture, second messengers and cocultured astrocytes

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Wolburg, H.
	Articles by Risau, W.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Wolburg, H.
	Articles by Risau, W.

Arthur, F. E., Shivers, R. R. and Bowman, P. D (1987). Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model. Dev. Brain Res 36, 155-159.

Brightman, M. W. and Reese, T. S (1969). Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol 40, 648-677.[Abstract/Free Full Text]

Bundgaard, M., Cserr, H. and Murray, M (1979). Impermeability of hagfish cerebral capillaries to horseradish peroxidase An ultrastructural study. Cell Tiss. Res 198, 65-77.[Medline]

Butt, A. M., Jones, H. C. and Abbott, N. J (1990). Electrical-resistance across the blood-brain barrier in anesthetized rats- a developmental study. J. Physiol 429, 47-62.

Citi, S (1993). The molecular-organization of tight junctions. J. Cell Biol 121, 485-489.[Free Full Text]

Claude, P. and Goodenough, D. A (1973). Fracture faces of zonulae occludentes from \322tight\323 and \322leaky\323 epithelia. J. Cell Biol 58, 390-400.[Abstract/Free Full Text]

Claude, P (1978). Morphological factors influencing transepithelial permeability: a model for the resistance of the zonula occludens. J. Membr. Biol 32, 219-232.

Dermietzel, R. and Krause, D (1991). Molecular anatomy of the blood-brain-barrier as defined by immunocytochemistry. Int. Rev. Cytol 127, 57-109.[Medline]

Drenckhahn, D. and Dermietzel, R (1988). Organization of the actin filament cytoskeleton in the intestinal brush border: a quantitative and qualitative immunoelectron microscope study. J. Cell Biol 107, 1037-1048.[Abstract/Free Full Text]

Frey, A., Meckelein, B., Weilerguttler, H., Mockel, B., Flach, R. and Gassen, H. G (1991). Pericytes of the brain microvasculature express gamma-glutamyl transpeptidase. Eur. J. Biochem 202, 421-429.[Medline]

Gumbiner, B. and Simons, K (1986). A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J. Cell Biol 102, 457-468.[Abstract/Free Full Text]

Itoh, M., Nagafuchi, A., Yonemura, S., Kitani-Yasuda, T., Tsukita, S. and Tsukita, S (1993). The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J. Cell Biol 121, 491-502.[Abstract/Free Full Text]

Janzer, R. C. and Raff, M. C (1987). Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325, 253-257.[Medline]

Kintner, C (1992). Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain. Cell 69, 225-236.[Medline]

Kniesel, U. and Wolburg, H (1993). Tight junction complexity in the retinal-pigment epithelium of the chicken during development. Neurosci. Lett 149, 71-74.[Medline]

Krause, D., Mischeck, U., Galla, H. J. and Dermietzel, R (1991). Correlation of zonula-occludens ZO-1 antigen expression and transendothelial resistance in porcine and rat cultured cerebral endothelial-cells. Neurosci. Lett 128, 301-304.[Medline]

Lampugnani, M. G., Resnati, M., Raiteri, M., Pigott, R., Pisacane, A., Houen, G., Ruco, L. P. and Dejana, E (1992). A novel endothelial-specific membrane-protein is a marker of cell-cell contacts. J. Cell Biol 118, 1511-1522.[Abstract/Free Full Text]

Madara, J. L. and Dharmsathaphorn, K (1985). Occluding junction structure-function relationships in a cultured epithelial monlayer. J. Cell Biol 101, 2124-2133.[Abstract/Free Full Text]

Madara, J. L (1987). Intestinal absorptive cell tight junctions are linked to cytoskeleton. Amer. J. Physiol 253, 171-.

Madara, J. L. and Pappenheimer, J. R (1987). Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J. Membr. Biol 100, 149-164.[Medline]

Mandel, L. J., Bacallao, R. and Zampighi, G (1993). Uncoupling of the molecular fence and paracellular gate functions in epithelial tight junctions. Nature 361, 552-555.[Medline]

Marcial, M. A., Carlson, S. L. and Madar, J. L (1984). Partitioning of paracellular conductance along the ileal crypt-villus axis: a hypothesis based on structural analysis with detailed considerations of tight junction structure-function relationship. J. Membr. Biol 80, 59-80.[Medline]

Meyer, J., Rauh J. and Galla, H. J (1991). The susceptibility of cerebral endothelial-cells to astroglial induction of blood-brain-barrier enzymes depends on their proliferative state. J. Neurochem 57, 1971-1977.[Medline]

Muhleisen, H., Wolburg, H. and Betz, E (1989). Freeze-fracture analysis of endothelial cell membranes in rabbit carotid arteries subjected to short-term atherogenic stimuli. Virch. Arch. B Cell Pathol 56, 413-417.[Medline]

Nagy, Z., Peters, H. and Huttner, I (1984). Fracture faces of cell junctions in cerebral endothelium during normal and hyperosmotic conditions. Lab. Invest 50, 313-322.[Medline]

Nigam, S. K., Denisenko, N., Rodriguez-Boulan, E. and Citi, S (1991). The role of phosphorylation in development of tight junctions in cultured renal epithelial (mdck) cells. Biochem. Biophys. Res. Commun 181, 548-553.[Medline]

Noble, M., Fok-Seang, J. and Cohen, J (1984). Glia are a unique substrate for the in vitro growth of central nervous system neurons. J. Neurosci 4, 1892-1903.[Abstract]

Ozawa, M. and Kemler, R (1992). Molecular-organization of the uvomorulin-catenin complex. J. Cell Biol 116, 989-996.[Abstract/Free Full Text]

Reese, T. S. and Karnovsky, M. J (1967). Fine structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell Biol 34, 207-217.[Abstract/Free Full Text]

Risau, W., Hallmann, R. and Albrecht, U (1986). Differentiation-dependent expression of protein in brain endothelium during development of the blood-brain barrier. Dev. Biol 117, 537-545.[Medline]

Risau, W., Hallmann, R., Albrecht, U. and Henke-Fahle, S (1986). Brain induces the expression of an early cell surface marker for blood-brain barrier specific endothelium. EMBO J 5, 3179-3183.[Medline]

Risau, W., Engelhardt, B. and Wekerle, H (1990). Immune function of the blood-brain barrier: Incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro. J. Cell Biol 110, 1757-1766.[Abstract/Free Full Text]

Risau, W. and Wolburg, H (1990). Development of the blood-brain barrier. Trends Neurosci 13, 174-178.[Medline]

Risau, W. and Wolburg, H (1991). The importance of the blood-brain barrier in fetuses and embryos- reply. Trends Neurosci 14, 15-15.

Risau, W., Dingler, A., Albrecht, U., Dehouck, M.-P. and Cecchelli, R (1992). Blood-brain barrier pericytes are the main source of gamma-glutamyltranspeptidase activity in brain capillaries. J. Neurochem 58, 667-672.[Medline]

Rubin, L. L., Hall, D. E., Porter, S., Barbu, K., Cannon, C., Horner, H. C., Janatpour, M., Liaw, C. W., Manning, K., Morales, J., Tanner, L. I., Tomaselli, K. J., et al (1991). A cell-culture model of the blood-brain barrier. J. Cell Biol 115, 1725-1735.[Abstract/Free Full Text]

Saunders, N. R., Dziegielewska, K. M. and Mollgard, K (1991). The importance of the blood-brain barrier in fetuses and embryos. Trends Neurosci 14, 14-14.[Medline]

Schulze, C. and Firth, J. A (1992). Interendothelial junctions during blood-brain barrier development in the rat, morphological changes at the level of individual tight junctional contacts. Dev. Brain Res 69, 85-95.[Medline]

Seulberger, H., Lottspeich, F. and Risau, W (1990). The inducible blood-brain barrier specific molecule HT7 is a novel immunoglobulin-like cell surface glycoprotein. EMBO J 9, 2151-2158.[Medline]

Simionescu, M., Ghinea, N., Fixman, A., Lasser, M., Kukes, L., Simionescu, N. and Palade, G. E (1988). The cerebral microvasculature of the rat: structure and luminal surface properties during early development. J. Submicrosc. Cytol 20, 243-261.

Stevenson, B. R., Anderson, J. M., Godenough, D. A. and Mooseker, M. S (1988). Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance. J. Cell Biol 107, 2401-2408.[Abstract/Free Full Text]

Stevenson, B. R., Anderson, J. M., Braun, D. and Mooseker, M. S (1989). Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance. Biochem. J 263, 597-599.[Medline]

Stewart, P. A. and Wiley, M. J (1981). Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimeras. Dev. Biol 84, 183-192.[Medline]

Stewart, P. A. and Hayakawa, E. M (1987). Interendothelial junctional changes underlie the developmental \324tightening' of the blood-brain barrier. Dev. Brain Res 32, 271-281.

Tao-Cheng, J., Nagy, Z. and Brightman, M. W (1987). Tight junctions of brain endothelium in vitro are enhanced by astroglia. J. Neurosci 7, 3293-3299.[Abstract]

van Deurs, B. and Luft, J. H (1979). Effects of glutaraldehyde fixation on the structure of tight junctions. A quantitative freeze-fracture analysis. J. Ultrastruct. Res 68, 160-172.[Medline]

Wakai, S. and Hirokawa, N (1978). Development of the blood-brain barrier to horseradish peroxidase in the chick embryo. Cell Tiss. Res 195, 195-203.[Medline]

Zampighi, G., Bacallao, R., Mandel, L. and Cereijido, M (1991). Structural differences of the tight junction between low and high resistance MDCK monolayers. J. Cell Biol 115, 479-.

This article has been cited by other articles:

J. Piontek, L. Winkler, H. Wolburg, S. L. Muller, N. Zuleger, C. Piehl, B. Wiesner, G. Krause, and I. E. Blasig
Formation of tight junction: determinants of homophilic interaction between classic claudins
FASEB J, January 1, 2008; 22(1): 146 - 158.
[Abstract] [Full Text] [PDF]

R. Polavarapu, M. C. Gongora, H. Yi, S. Ranganthan, D. A. Lawrence, D. Strickland, and M. Yepes
Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit
Blood, April 15, 2007; 109(8): 3270 - 3278.
[Abstract] [Full Text] [PDF]

C. D. Anfuso, G. Lupo, L. Romeo, G. Giurdanella, C. Motta, A. Pascale, C. Tirolo, B. Marchetti, and M. Alberghina
Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of PKC{alpha} and the MAPK/ERK cascade
J. Lipid Res., April 1, 2007; 48(4): 782 - 793.
[Abstract] [Full Text] [PDF]

H. Tu, A. J. Kastin, and W. Pan
Corticotropin-Releasing Hormone Receptor (CRHR)1 and CRHR2 Are Both Trafficking and Signaling Receptors for Urocortin
Mol. Endocrinol., March 1, 2007; 21(3): 700 - 711.
[Abstract] [Full Text] [PDF]

S. Schrot, C. Weidenfeller, T. E. Schaffer, H. Robenek, and H.-J. Galla
Influence of Hydrocortisone on the Mechanical Properties of the Cerebral Endothelium In Vitro
Biophys. J., December 1, 2005; 89(6): 3904 - 3910.
[Abstract] [Full Text] [PDF]

H. Xu, R. Dawson, I. J. Crane, and J. Liversidge
Leukocyte Diapedesis In Vivo Induces Transient Loss of Tight Junction Protein at the Blood-Retina Barrier
Invest. Ophthalmol. Vis. Sci., July 1, 2005; 46(7): 2487 - 2494.
[Abstract] [Full Text] [PDF]

J. R. Carlson, W. L. W. Chang, S. S. Zhou, A. F. Tarantal, and P. A. Barry
Rhesus brain microvascular endothelial cells are permissive for rhesus cytomegalovirus infection
J. Gen. Virol., March 1, 2005; 86(3): 545 - 549.
[Abstract] [Full Text] [PDF]

X. Gu, J. Zhang, D. W. Brann, and F.-S. X. Yu
Brain and Retinal Vascular Endothelial Cells with Extended Life Span Established by Ectopic Expression of Telomerase
Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 3219 - 3225.
[Abstract] [Full Text] [PDF]

T. Sato, Y. Morishima, and Y. Shirasaki
3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e), a Novel Calmodulin Antagonist, Reduces Brain Edema through the Inhibition of Enhanced Blood-Brain Barrier Permeability after Transient Focal Ischemia
J. Pharmacol. Exp. Ther., March 1, 2003; 304(3): 1042 - 1047.
[Abstract] [Full Text] [PDF]

R. C. Brown, K. S. Mark, R. D. Egleton, J. D. Huber, A. R. Burroughs, and T. P. Davis
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NF{kappa}B
J. Cell Sci., February 15, 2003; 116(4): 693 - 700.
[Abstract] [Full Text] [PDF]

M. Furuse, K. Furuse, H. Sasaki, and S. Tsukita
Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells
J. Cell Biol., April 9, 2001; 153(2): 263 - 272.
[Abstract] [Full Text] [PDF]

S. Fischer, M. Wobben, J. Kleinstuck, D. Renz, and W. Schaper
Effect of astroglial cells on hypoxia-induced permeability in PBMEC cells
Am J Physiol Cell Physiol, October 1, 2000; 279(4): C935 - C944.
[Abstract] [Full Text] [PDF]

H. Utsumi, H. Chiba, Y. Kamimura, M. Osanai, Y. Igarashi, H. Tobioka, M. Mori, and N. Sawada
Expression of GFRalpha -1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB
Am J Physiol Cell Physiol, August 1, 2000; 279(2): C361 - C368.
[Abstract] [Full Text] [PDF]

D. Li and R. J. Mrsny
Oncogenic Raf-1 Disrupts Epithelial Tight Junctions via Downregulation of Occludin
J. Cell Biol., February 21, 2000; 148(4): 791 - 800.
[Abstract] [Full Text] [PDF]

C Johnson-Leger, M Aurrand-Lions, and B. Imhof
The parting of the endothelium: miracle, or simply a junctional affair?
J. Cell Sci., January 3, 2000; 113(6): 921 - 933.
[Abstract] [PDF]

A. Burns, R. Bowden, S. MacDonell, D. Walker, T. Odebunmi, E. Donnachie, S. Simon, M. Entman, and C. Smith
Analysis of tight junctions during neutrophil transendothelial migration
J. Cell Sci., January 1, 2000; 113(1): 45 - 57.
[Abstract] [PDF]

K. Morita, H. Sasaki, M. Furuse, and S. Tsukita
Endothelial Claudin: Claudin-5/TMVCF Constitutes Tight Junction Strands in Endothelial Cells
J. Cell Biol., October 4, 1999; 147(1): 185 - 194.
[Abstract] [Full Text] [PDF]

N. Sonoda, M. Furuse, H. Sasaki, S. Yonemura, J. Katahira, Y. Horiguchi, and S. Tsukita
Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands: Evidence for Direct Involvement of Claudins in Tight Junction Barrier
J. Cell Biol., October 4, 1999; 147(1): 195 - 204.
[Abstract] [Full Text] [PDF]

C. C. Michel and F. E. Curry
Microvascular Permeability
Physiol Rev, July 1, 1999; 79(3): 703 - 761.
[Abstract] [Full Text] [PDF]

C. A. Hathaway, C. B. Appleyard, W. H. Percy, and J. L. Williams
Experimental colitis increases blood-brain barrier permeability in rabbits
Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1174 - G1180.
[Abstract] [Full Text] [PDF]

S. Bamforth, U Kniesel, H Wolburg, B Engelhardt, and W Risau
A dominant mutant of occludin disrupts tight junction structure and function
J. Cell Sci., January 6, 1999; 112(12): 1879 - 1888.
[Abstract] [PDF]

T. Korff and H. G. Augustin
Integration of Endothelial Cells in Multicellular Spheroids Prevents Apoptosis and Induces Differentiation
J. Cell Biol., November 30, 1998; 143(5): 1341 - 1352.
[Abstract] [Full Text] [PDF]

M. Furuse, H. Sasaki, K. Fujimoto, and S. Tsukita
A Single Gene Product, Claudin-1 or -2,�Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts
J. Cell Biol., October 19, 1998; 143(2): 391 - 401.
[Abstract] [Full Text] [PDF]

R. H. Adamson, B. Liu, G. N. Fry, L. L. Rubin, and F. E. Curry
Microvascular permeability and number of tight junctions are modulated by cAMP
Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H1885 - H1894.
[Abstract] [Full Text] [PDF]

S. Duport, F. Robert, D. Muller, G. Grau, L. Parisi, and L. Stoppini
An in vitro blood-brain barrier model: Cocultures between endothelial cells and organotypic brain slice�cultures
PNAS, February 17, 1998; 95(4): 1840 - 1845.
[Abstract] [Full Text] [PDF]

V. Wong
Phosphorylation of occludin correlates with occludin localization and function at the tight junction
Am J Physiol Cell Physiol, December 1, 1997; 273(6): C1859 - C1867.
[Abstract] [Full Text] [PDF]

B. Engelhardt, D. Vestweber, R. Hallmann, and M. Schulz
E- and P-Selectin Are Not Involved in the Recruitment of Inflammatory Cells Across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis
Blood, December 1, 1997; 90(11): 4459 - 4472.
[Abstract] [Full Text] [PDF]

C. Garlanda and E. Dejana
Heterogeneity of Endothelial Cells : Specific Markers
Arterioscler. Thromb. Vasc. Biol., July 1, 1997; 17(7): 1193 - 1202.
[Abstract] [Full Text]

V. Wong and B. M. Gumbiner
A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier
J. Cell Biol., January 27, 1997; 136(2): 399 - 409.
[Abstract] [Full Text] [PDF]

G. I. Gorodeski
The Cultured Human Cervical Epithelium: A New Model for Studying Paracellular Transport
Reproductive Sciences, September 1, 1996; 3(5): 267 - 280.
[Abstract] [PDF]

M. Aurrand-Lions, L. Duncan, C. Ballestrem, and B. A. Imhof
JAM-2, a Novel Immunoglobulin Superfamily Molecule, Expressed by Endothelial and Lymphatic Cells
J. Biol. Chem., January 19, 2001; 276(4): 2733 - 2741.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Wolburg, H.

Articles by Risau, W.

Search for Related Content

PubMed

PubMed Citation

Articles by Wolburg, H.

Articles by Risau, W.

				R. Polavarapu, M. C. Gongora, H. Yi, S. Ranganthan, D. A. Lawrence, D. Strickland, and M. Yepes Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit Blood, April 15, 2007; 109(8): 3270 - 3278. [Abstract] [Full Text] [PDF]

				C. D. Anfuso, G. Lupo, L. Romeo, G. Giurdanella, C. Motta, A. Pascale, C. Tirolo, B. Marchetti, and M. Alberghina Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of PKC{alpha} and the MAPK/ERK cascade J. Lipid Res., April 1, 2007; 48(4): 782 - 793. [Abstract] [Full Text] [PDF]

				H. Tu, A. J. Kastin, and W. Pan Corticotropin-Releasing Hormone Receptor (CRHR)1 and CRHR2 Are Both Trafficking and Signaling Receptors for Urocortin Mol. Endocrinol., March 1, 2007; 21(3): 700 - 711. [Abstract] [Full Text] [PDF]

				S. Schrot, C. Weidenfeller, T. E. Schaffer, H. Robenek, and H.-J. Galla Influence of Hydrocortisone on the Mechanical Properties of the Cerebral Endothelium In Vitro Biophys. J., December 1, 2005; 89(6): 3904 - 3910. [Abstract] [Full Text] [PDF]

				H. Xu, R. Dawson, I. J. Crane, and J. Liversidge Leukocyte Diapedesis In Vivo Induces Transient Loss of Tight Junction Protein at the Blood-Retina Barrier Invest. Ophthalmol. Vis. Sci., July 1, 2005; 46(7): 2487 - 2494. [Abstract] [Full Text] [PDF]

				J. R. Carlson, W. L. W. Chang, S. S. Zhou, A. F. Tarantal, and P. A. Barry Rhesus brain microvascular endothelial cells are permissive for rhesus cytomegalovirus infection J. Gen. Virol., March 1, 2005; 86(3): 545 - 549. [Abstract] [Full Text] [PDF]

				X. Gu, J. Zhang, D. W. Brann, and F.-S. X. Yu Brain and Retinal Vascular Endothelial Cells with Extended Life Span Established by Ectopic Expression of Telomerase Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 3219 - 3225. [Abstract] [Full Text] [PDF]

				T. Sato, Y. Morishima, and Y. Shirasaki 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e), a Novel Calmodulin Antagonist, Reduces Brain Edema through the Inhibition of Enhanced Blood-Brain Barrier Permeability after Transient Focal Ischemia J. Pharmacol. Exp. Ther., March 1, 2003; 304(3): 1042 - 1047. [Abstract] [Full Text] [PDF]

				R. C. Brown, K. S. Mark, R. D. Egleton, J. D. Huber, A. R. Burroughs, and T. P. Davis Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NF{kappa}B J. Cell Sci., February 15, 2003; 116(4): 693 - 700. [Abstract] [Full Text] [PDF]

				M. Furuse, K. Furuse, H. Sasaki, and S. Tsukita Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells J. Cell Biol., April 9, 2001; 153(2): 263 - 272. [Abstract] [Full Text] [PDF]

				S. Fischer, M. Wobben, J. Kleinstuck, D. Renz, and W. Schaper Effect of astroglial cells on hypoxia-induced permeability in PBMEC cells Am J Physiol Cell Physiol, October 1, 2000; 279(4): C935 - C944. [Abstract] [Full Text] [PDF]

				H. Utsumi, H. Chiba, Y. Kamimura, M. Osanai, Y. Igarashi, H. Tobioka, M. Mori, and N. Sawada Expression of GFRalpha -1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB Am J Physiol Cell Physiol, August 1, 2000; 279(2): C361 - C368. [Abstract] [Full Text] [PDF]

				D. Li and R. J. Mrsny Oncogenic Raf-1 Disrupts Epithelial Tight Junctions via Downregulation of Occludin J. Cell Biol., February 21, 2000; 148(4): 791 - 800. [Abstract] [Full Text] [PDF]

				C Johnson-Leger, M Aurrand-Lions, and B. Imhof The parting of the endothelium: miracle, or simply a junctional affair? J. Cell Sci., January 3, 2000; 113(6): 921 - 933. [Abstract] [PDF]

				A. Burns, R. Bowden, S. MacDonell, D. Walker, T. Odebunmi, E. Donnachie, S. Simon, M. Entman, and C. Smith Analysis of tight junctions during neutrophil transendothelial migration J. Cell Sci., January 1, 2000; 113(1): 45 - 57. [Abstract] [PDF]

				K. Morita, H. Sasaki, M. Furuse, and S. Tsukita Endothelial Claudin: Claudin-5/TMVCF Constitutes Tight Junction Strands in Endothelial Cells J. Cell Biol., October 4, 1999; 147(1): 185 - 194. [Abstract] [Full Text] [PDF]

				N. Sonoda, M. Furuse, H. Sasaki, S. Yonemura, J. Katahira, Y. Horiguchi, and S. Tsukita Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands: Evidence for Direct Involvement of Claudins in Tight Junction Barrier J. Cell Biol., October 4, 1999; 147(1): 195 - 204. [Abstract] [Full Text] [PDF]

				C. C. Michel and F. E. Curry Microvascular Permeability Physiol Rev, July 1, 1999; 79(3): 703 - 761. [Abstract] [Full Text] [PDF]

				C. A. Hathaway, C. B. Appleyard, W. H. Percy, and J. L. Williams Experimental colitis increases blood-brain barrier permeability in rabbits Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1174 - G1180. [Abstract] [Full Text] [PDF]

				S. Bamforth, U Kniesel, H Wolburg, B Engelhardt, and W Risau A dominant mutant of occludin disrupts tight junction structure and function J. Cell Sci., January 6, 1999; 112(12): 1879 - 1888. [Abstract] [PDF]

				T. Korff and H. G. Augustin Integration of Endothelial Cells in Multicellular Spheroids Prevents Apoptosis and Induces Differentiation J. Cell Biol., November 30, 1998; 143(5): 1341 - 1352. [Abstract] [Full Text] [PDF]

				M. Furuse, H. Sasaki, K. Fujimoto, and S. Tsukita A Single Gene Product, Claudin-1 or -2,�Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts J. Cell Biol., October 19, 1998; 143(2): 391 - 401. [Abstract] [Full Text] [PDF]

				R. H. Adamson, B. Liu, G. N. Fry, L. L. Rubin, and F. E. Curry Microvascular permeability and number of tight junctions are modulated by cAMP Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H1885 - H1894. [Abstract] [Full Text] [PDF]

				S. Duport, F. Robert, D. Muller, G. Grau, L. Parisi, and L. Stoppini An in vitro blood-brain barrier model: Cocultures between endothelial cells and organotypic brain slice�cultures PNAS, February 17, 1998; 95(4): 1840 - 1845. [Abstract] [Full Text] [PDF]

				V. Wong Phosphorylation of occludin correlates with occludin localization and function at the tight junction Am J Physiol Cell Physiol, December 1, 1997; 273(6): C1859 - C1867. [Abstract] [Full Text] [PDF]

				B. Engelhardt, D. Vestweber, R. Hallmann, and M. Schulz E- and P-Selectin Are Not Involved in the Recruitment of Inflammatory Cells Across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis Blood, December 1, 1997; 90(11): 4459 - 4472. [Abstract] [Full Text] [PDF]

				C. Garlanda and E. Dejana Heterogeneity of Endothelial Cells : Specific Markers Arterioscler. Thromb. Vasc. Biol., July 1, 1997; 17(7): 1193 - 1202. [Abstract] [Full Text]

				V. Wong and B. M. Gumbiner A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier J. Cell Biol., January 27, 1997; 136(2): 399 - 409. [Abstract] [Full Text] [PDF]

				G. I. Gorodeski The Cultured Human Cervical Epithelium: A New Model for Studying Paracellular Transport Reproductive Sciences, September 1, 1996; 3(5): 267 - 280. [Abstract] [PDF]

				M. Aurrand-Lions, L. Duncan, C. Ballestrem, and B. A. Imhof JAM-2, a Novel Immunoglobulin Superfamily Molecule, Expressed by Endothelial and Lymphatic Cells J. Biol. Chem., January 19, 2001; 276(4): 2733 - 2741. [Abstract] [Full Text] [PDF]