Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

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Allan, D. J., Howell, A., Roberts, S. A., Williams, G. T., Watson, R. J., Coyne, J. D., Clarke, R. B., Laidlaw, I. J. and Potten, C. S (1992). Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic change and carcinoma of the premenopausal human breast. J. Pathol 167, 25-32.[Medline]

Ansari, B., Coates, P. J., Greenstein, B. and Hall, P. A (1993). In situ end labelling (ISEL) detects DNA strand breaks in apoptosis and in other physiological and pathological states. J. Pathol 170, 1-8.[Medline]

Avery, A., Paraskeva, C., Hall, P., Flanders, K. C., Sporn, M. and Moorghen, M (1993). TGFexpression in the human colon: differential immunostaining along crypt epithelium. Br. J. Cancer 68, 137-139.[Medline]

Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D. and Raff, M. C (1992). Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70, 31-46.[Medline]

Beaulieu, J.-F (1992). Differential expression of the VLA family of integrins along the crypt villus axis in the human small intestine. J. Cell Sci 102, 427-436.[Abstract/Free Full Text]

Bennedetti, A., Jezequel, A. M. and Orlandi, F (1988). A quantitative evaluation of apoptotic bodies in rat liver. Liver 8, 172-177.[Medline]

Cheng, H. and Leblond, C. P (1974). Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types. Am. J. Anat 141, 537-562.[Medline]

Coles, H. S. R., Burne, J. F. and Raff, M. C (1993). Large scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 118, 777-784.[Abstract]

Creamer, B., Shorter, R. G. and Bamford J (1961). The turnover and shedding of epithelial cells. Part II. The shedding in the small intestine. Gut 2, 117-118.[Abstract/Free Full Text]

Croft, D. N. and Cotton, P. B (1973). Gastrointestinal cell loss in man. Its measurement and significance. Digestion 8, 144-160.[Medline]

David, H (1967). Zum mechanismus der zellastobung im bereich der Dunndarmzotten (elektronenmikroskopishe untersuchungen). (The mechanism of desquamation of cells from the intestinal villi: an electron microscopic study). Virchow. Archiv. [Pathol. Anat.] 342, 19-25.

Del Buono R., Fleming, K. A., Morey A. L., Hall, P. A. and Wright, N. A (1992). A nude mouse xenograft model of fetal intestine development and differentiation. Development 114, 67-73.[Abstract]

Doherty, P. and Walsh, F. S (1994). Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules. Curr. Opin. Neurobiol 4, 49-55.[Medline]

Ellis, R. E., Yuan, J. and Horwitz, H. R (1991). Mechanisms and functions of cell death. Annu. Rev. Cell Biol 7, 663-669.

Ferriera, M. N. and Leblond, C. P (1971). Argentaffin and other endocrine cells of the small intestine and the adult mouse. II. Renewal. Am. J. Anat 131, 331-342.[Medline]

Frisch, S. M. and Francis, H (1994). Disruption of epithelial cell matrix interactions induces apoptosis. J. Cell Biol 124, 619-626.[Abstract/Free Full Text]

Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A (1992). Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J. Cell Biol 119, 493-501.[Abstract/Free Full Text]

Glucksmann, A (1951). Cell deaths in normal vertebrate ontogeny. Biol. Rev 26, 59-86.

Hauft, S. M., Kim, S. H., Schmidt, G. H., Pease, S., Rees, S., Harris, S., Roth, K, A., Hansbrough, J. R., Cohn, S. M., Ahnen, D. J., Wright, N. A., Goodlad, R. A. and Gordon, J. I (1992). Expression of the SV-40 T antigen in the small intestinal epithelium of transgenic mice results in proliferative changes in the crypt and reentry of villus-associated enterocytes into the cell cycle, but has no apparent effect on cellular differentiation programs and does not cause neoplastic transformation. J. Cell Biol 117, 825-839.[Abstract/Free Full Text]

Hopwood, D. and Levison, D. A (1976). Atrophy and apoptosis in the cyclical human endometrium. J. Pathol 119, 159-166.[Medline]

Kerr, J. F. R., Wyllie, A. H. and Currie, A. R (1972). Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.[Medline]

Lee, F. D (1993). Importance of apoptosis in the histopathology of drug related lesions in the small intestine. J. Clin. Pathol 46, 118-122.[Abstract/Free Full Text]

Marsh, M. N. and Trier, J. S (1974). Morphology and cell proliferation ofsubepithelial fibroblasts in adult mouse jejunum. I. Structural features. Gastroenterol 67, 622-635.[Medline]

Marsh, M. N. and Trier, J. S (1974). Morphology and cell proliferation of subepithelial fibroblasts in adult mouse jejunum. II. Radioautographic studies. Gastroenterology 67, 636-645.[Medline]

Merritt, A., Potten, C. A., Kempt, C. J., Hickman, J. A., Balmain, A., Lane, D. P. and Hall, P. A (1994). The role of p53 in spontaneous and radiation induced apoptosis in the gastrointestinal tract of normal and p53 deficient mice. Cancer Res 54, 614-617.[Abstract/Free Full Text]

Messier, B. and Leblond, C. P (1960). Cell proliferation and migration as revealed by autoradiography after injection of thymidine-3H into male rats and mice. Am. J. Anat 106, 247-285.[Medline]

Oppenheim, R. W (1991). Cell death during development of the nervous system. Annu. Rev. Neurosci 14, 453-501.[Medline]

Parker, F. G., Barnes, E. N. and Kaye, G. I (1974). The pericryptal fibroblast sheath. IV. Replication, migration and differentiation of the subepithelial fibroblasts of the crypt and villus of the rabbit jejunum. Gastroenterology 67, 607-621.[Medline]

Pascal, R. R., Kaye, G. I. and Lane, N (1968). Colonic pericryptal fibroblast sheath: replication, migration and cytodifferentiation of a mesenchymal cell system in adult tissue. I. Autoradiographic studies of normal rabbit colon. Gastroenterology 54, 835-851.[Medline]

Pascal, R. R., Kaye, G. I. and Lane, N (1968). Colonic pericryptal fibroblast sheath: replication, migration and cytodifferentiationof a mesenchymal cell system in adult tissue. II. Fine structural aspects of normal rabbit and human colon. Gastroenterology 54, 852-865.[Medline]

Pink, I. J., Croft, D. N. and Creamer, B (1970). Cell loss from small intestinal mucosa: a morphological study. Gut 11, 217-222.[Abstract/Free Full Text]

Potten, C. S (1977). Extreme sensitivity of some intestinal crypt cells to X andirradiation. Nature 169, 518-521.

Potten, C. S. and Loeffler, M (1990). Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110, 1001-1020.[Abstract/Free Full Text]

Potten, C. S., Owen, G. and Roberts, S. A (1990). The temporal and spatial changes in cell proliferation within the irradiated crypts of the murine small intestine. Int. J. Radiat. Biol 57, 185-199.[Medline]

Potten, C. S., Li, Q., O'Connor, P. J. and Winton, D. J (1992). A possible explanation for the differential cancer incidence in the intestine, based upon distribution of the cytotoxic effects of carcinogens in the murine large bowel. Carcinogenesis 13, 2305-2312.[Abstract/Free Full Text]

Probsteimer, R., Martini, R. and Schachner, M (1990). Expression of J1/tenascin in the crypt-villus unit of the adult mouse small intestine: implications for its role in epithelial cell shedding. Development 109, 313-321.[Abstract]

Raff, M. C (1992). Social controls on cell survival and cell death. Nature 356, 397-400.[Medline]

Rubinfield, B., Souza, B. Albert, I., Muller, O., Chamberlain, S. H., Masiarz, F. R., Munemitsu, S. and Polakis, P (1993). Association of the APC gene product with-catenin. Science 262, 1731-1734.[Abstract/Free Full Text]

Sato, M. and Ahnen, D. J (1992). Regional variability of colonocyte growth and differentiation in the rat. Anat. Record 233, 409-414.[Medline]

Saunders, J. W (1966). Death in embryonic systems. Science 154, 604-612.[Abstract/Free Full Text]

Strange, R., Li, F., Saurer, S., Burkhardt, A. and Friis, R. R (1992). Apoptotic cell death and tissue remodelling during mouse mammary gland involution. Development 115, 49-58.[Abstract]

Su, L.-K., Vogelstein, B. and Kinzler, K. W (1993). Association of the APC tumour suppressor protein with catenins. Science 262, 1734-1737.[Abstract/Free Full Text]

Tsubouchi, S. and Leblond, C. P (1979). Migration and turnover of enteroendocrine and caveolated cells in the epithelium of the descending colon, as shown by radioautography after continuous infusions of 3H-thymidine in mice. Am. J. Anat 156, 431-451.[Medline]

Walker, N. I (1987). Ultrastructure of the rat pancreas after experimental duct ligation. Am. J. Pathol 126, 439-451.[Abstract]

Walker, N. I., Bennett, R. E. and Axelsen, R. A (1988). Melanosis coli. A consequence of anthraquinone-induced apoptosis of colonic epithelial cells. Am. J. Pathol 131, 465-476.[Abstract]

Yeomans, N. D. and Trier, J. S (1976). Epithelial cell proliferation and migration in the developing gastric mucosa. Dev. Biol 53, 206-216.[Medline]

Zajicek, G., Yagil, C. and Michaeli, Y (1985). The streaming submandibular gland. Anat. Record 213, 150-158.[Medline]

Zajicek, G., Ariel, I. and Arber, N (1986). The streaming adrenal cortex: direct evidence of centripetal migration of adrenocytes by estimation of turnover rate. J. Endocrinol 111, 477-482.[Abstract/Free Full Text]

Zajicek, G., Ariel, I. and Arber, N (1988). The streaming liver. III. Littoral cells accompany the streaming hepatocyte. Liver 8, 213-218.[Medline]

Zajicek, G. and Arber N (1991). Streaming kidney. Cell Prolif 24, 375-382.[Medline]

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M W Bennett, J O'Connell, A Houston, J Kelly, G C O'Sullivan, J K Collins, and F Shanahan
Fas ligand upregulation is an early event in colonic carcinogenesis
J. Clin. Pathol., August 1, 2001; 54(8): 598 - 604.
[Abstract] [Full Text] [PDF]

T. S. Stappenbeck and J. I. Gordon
Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice
Development, July 1, 2001; 128(13): 2603 - 2614.
[Abstract] [Full Text] [PDF]

				E. Q. Haxhija, H. Yang, A. U. Spencer, H. Koga, X. Sun, and D. H. Teitelbaum Modulation of mouse intestinal epithelial cell turnover in the absence of angiotensin converting enzyme Am J Physiol Gastrointest Liver Physiol, July 1, 2008; 295(1): G88 - G98. [Abstract] [Full Text] [PDF]

				Y. Wang, K. Srinivasan, M. R. Siddiqui, S. P. George, A. Tomar, and S. Khurana A Novel Role for Villin in Intestinal Epithelial Cell Survival and Homeostasis J. Biol. Chem., April 4, 2008; 283(14): 9454 - 9464. [Abstract] [Full Text] [PDF]

				A. Bank, P. Wang, C. Du, J. Yu, and L. Zhang SMAC Mimetics Sensitize Nonsteroidal Anti-inflammatory Drug Induced Apoptosis by Promoting Caspase-3 Mediated Cytochrome c Release Cancer Res., January 1, 2008; 68(1): 276 - 284. [Abstract] [Full Text] [PDF]

				B. Halder, U. Bhattacharya, S. Mukhopadhyay, and A. K. Giri Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade Carcinogenesis, January 1, 2008; 29(1): 129 - 138. [Abstract] [Full Text] [PDF]

				B. P. Willing and A. G. Van Kessel Enterocyte proliferation and apoptosis in the caudal small intestine is influenced by the composition of colonizing commensal bacteria in the neonatal gnotobiotic pig J Anim Sci, December 1, 2007; 85(12): 3256 - 3266. [Abstract] [Full Text] [PDF]

				C. N. Kundu, R. Balusu, A. S. Jaiswal, and S. Narayan Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways Carcinogenesis, October 1, 2007; 28(10): 2089 - 2095. [Abstract] [Full Text] [PDF]

				L. Wang, Y. Tang, D. C. Rubin, and M. S. Levin Chronically administered retinoic acid has trophic effects in the rat small intestine and promotes adaptation in a resection model of short bowel syndrome Am J Physiol Gastrointest Liver Physiol, June 1, 2007; 292(6): G1559 - G1569. [Abstract] [Full Text] [PDF]

				B. Wu, W. Qiu, P. Wang, H. Yu, T. Cheng, G. P Zambetti, L. Zhang, and J. Yu p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion Gut, May 1, 2007; 56(5): 645 - 654. [Abstract] [Full Text] [PDF]

				S. Jin, R. M. Ray, and L. R. Johnson Rac1 mediates intestinal epithelial cell apoptosis via JNK Am J Physiol Gastrointest Liver Physiol, December 1, 2006; 291(6): G1137 - G1147. [Abstract] [Full Text] [PDF]

				Z.-F. Liu, C.-Y. Chen, W. Tang, J.-Y. Zhang, Y.-Q. Gong, and J.-H. Jia Gene-expression profiles in gastric epithelial cells stimulated with spiral and coccoid Helicobacter pylori. J. Med. Microbiol., August 1, 2006; 55(Pt 8): 1009 - 1015. [Abstract] [Full Text] [PDF]

				M. V. Swamy, J. M.R. Patlolla, V. E. Steele, L. Kopelovich, B. S. Reddy, and C. V. Rao Chemoprevention of Familial Adenomatous Polyposis by Low Doses of Atorvastatin and Celecoxib Given Individually and in Combination to APCMin Mice. Cancer Res., July 15, 2006; 66(14): 7370 - 7377. [Abstract] [Full Text] [PDF]

				M. Leslie Hold on for dear life J. Cell Biol., April 24, 2006; 173(2): 151 - 151. [Full Text] [PDF]

				B. S. Reddy, C. X. Wang, A.-N. Kong, T. O. Khor, X. Zheng, V. E. Steele, L. Kopelovich, and C. V. Rao Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in f 344 rats. Cancer Res., April 15, 2006; 66(8): 4542 - 4546. [Abstract] [Full Text] [PDF]

				M. Toruner, M. Fernandez-Zapico, J. J. Sha, L. Pham, R. Urrutia, and L. J. Egan Antianoikis Effect of Nuclear Factor-{kappa}B through Up-regulated Expression of Osteoprotegerin, BCL-2, and IAP-1 J. Biol. Chem., March 31, 2006; 281(13): 8686 - 8696. [Abstract] [Full Text] [PDF]

				M. Ohgushi, S. Kuroki, H. Fukamachi, L. A. O'Reilly, K. Kuida, A. Strasser, and S. Yonehara Transforming Growth Factor {beta}-Dependent Sequential Activation of Smad, Bim, and Caspase-9 Mediates Physiological Apoptosis in Gastric Epithelial Cells Mol. Cell. Biol., November 15, 2005; 25(22): 10017 - 10028. [Abstract] [Full Text] [PDF]

				A. Grishin, H. Ford, J. Wang, H. Li, V. Salvador-Recatala, E. S. Levitan, and E. Zaks-Makhina Attenuation of apoptosis in enterocytes by blockade of potassium channels Am J Physiol Gastrointest Liver Physiol, November 1, 2005; 289(5): G815 - G821. [Abstract] [Full Text] [PDF]

				W. Deng, M. J. Viar, and L. R. Johnson Polyamine depletion inhibits irradiation-induced apoptosis in intestinal epithelia Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G599 - G606. [Abstract] [Full Text] [PDF]

				T. Zou, J. N. Rao, L. Liu, B. S. Marasa, K. M. Keledjian, A.-H. Zhang, L. Xiao, B. L. Bass, and J.-Y. Wang Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells Am J Physiol Cell Physiol, September 1, 2005; 289(3): C686 - C696. [Abstract] [Full Text] [PDF]

				H. Mitomi, I. Okayasu, M. P. Bronner, H. Kanazawa, Y. Nishiyama, Y. Otani, M. Sada, S. Tanabe, M. Igarashi, T. Katsumata, et al. Comparative Histologic Assessment of Proctocolectomy Specimens from Japanese and American Patients with Ulcerative Colitis with or Without Dysplasia International Journal of Surgical Pathology, July 1, 2005; 13(3): 259 - 265. [Abstract] [PDF]

				J. M. Pagel, C. Laugen, L. Bonham, R. C. Hackman, D. M. Hockenbery, R. Bhatt, D. Hollenback, H. Carew, J. W. Singer, and O. W. Press Induction of Apoptosis Using Inhibitors of Lysophosphatidic Acid Acyltransferase-{beta} and Anti-CD20 Monoclonal Antibodies for Treatment of Human Non-Hodgkin's Lymphomas Clin. Cancer Res., July 1, 2005; 11(13): 4857 - 4866. [Abstract] [Full Text] [PDF]

				G. Zhu, H. Chen, B.-K. Choi, F. Del Piero, and D. M. Schifferli Histone H1 Proteins Act As Receptors for the 987P Fimbriae of Enterotoxigenic Escherichia coli J. Biol. Chem., June 17, 2005; 280(24): 23057 - 23065. [Abstract] [Full Text] [PDF]

				R. K. Le Leu, I. L. Brown, Y. Hu, A. R. Bird, M. Jackson, A. Esterman, and G. P. Young A Synbiotic Combination of Resistant Starch and Bifidobacterium lactis Facilitates Apoptotic Deletion of Carcinogen-Damaged Cells in Rat Colon J. Nutr., May 1, 2005; 135(5): 996 - 1001. [Abstract] [Full Text] [PDF]

				J. A. Clark, R. H. Lane, N. K. MacLennan, H. Holubec, K. Dvorakova, M. D. Halpern, C. S. Williams, C. M. Payne, and B. Dvorak Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis Am J Physiol Gastrointest Liver Physiol, April 1, 2005; 288(4): G755 - G762. [Abstract] [Full Text] [PDF]

				M. A. Wooters, M. B. Hildreth, E. A. Nelson, and A. K. Erickson Immunohistochemical Characterization of the Distribution of Galectin-4 in Porcine Small Intestine J. Histochem. Cytochem., February 1, 2005; 53(2): 197 - 205. [Abstract] [Full Text] [PDF]

				K. Steigerwald, G. K. Behbehani, K. A. Combs, M. C. Barton, and J. Groden The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitro Mol. Cancer Res., February 1, 2005; 3(2): 78 - 89. [Abstract] [Full Text] [PDF]

				J. M. Kiely, J.-H. Noh, H. A. Pitt, and D. A. Swartz-Basile Impaired Intestinal Cell Proliferation and Cell Death in Leptin-Deficient Obese Mice JPEN J Parenter Enteral Nutr, January 1, 2005; 29(1): 30 - 35. [Abstract] [Full Text] [PDF]

				A J M Watson Apoptosis and colorectal cancer Gut, November 1, 2004; 53(11): 1701 - 1709. [Full Text] [PDF]

				H. Kitazawa, T. Nishihara, T. Nambu, H. Nishizawa, M. Iwaki, A. Fukuhara, T. Kitamura, M. Matsuda, and I. Shimomura Intectin, a Novel Small Intestine-specific Glycosylphosphatidylinositol-anchored Protein, Accelerates Apoptosis of Intestinal Epithelial Cells J. Biol. Chem., October 8, 2004; 279(41): 42867 - 42874. [Abstract] [Full Text] [PDF]

				J. C. H. Hardwick, M. van Santen, G. R. van den Brink, S. J. H. van Deventer, and M. P. Peppelenbosch DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1 Carcinogenesis, July 1, 2004; 25(7): 1293 - 1298. [Abstract] [Full Text] [PDF]

				F. A. Sinicrope, E. Half, J. S. Morris, P. M. Lynch, J. D. Morrow, B. Levin, E. T. Hawk, D. S. Cohen, G. D. Ayers, and L. C. Stephens Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial Adenomatous Polyposis Patients Cancer Epidemiol. Biomarkers Prev., June 1, 2004; 13(6): 920 - 927. [Abstract] [Full Text] [PDF]