The processing pathway of prelamin A

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Ashby, M. N., King, D. S. and Rine, J (1992). Endoproteolytic processing of a farnesylated peptide in vitro. Proc. Nat. Acad. Sci. USA 89, 4613-4617.[Abstract/Free Full Text]

Beck, L. A., Hosick, T. J. and Sinensky, M (1990). Isoprenylation is required for the processing of the lamin A precursor. J. Cell Biol 110, 1489-1499.[Abstract/Free Full Text]

Casey, P. J., Solski, P. A., Der, C. J. and Buss, J. E (1989). p21ras is modified by a farnesyl isoprenoid. Proc. Nat. Acad. Sci. USA 86, 8323-8327.[Abstract/Free Full Text]

Chelsky, D., Olson, J. F. and Koshland, D. E. Jr (1987). Cell cycle-dependent methyl esterification of lamin B. J. Biol. Chem 262, 4303-4309.[Abstract/Free Full Text]

Cox, A. D. and Der, C. J (1992). Protein prenylation: more than just glue?. Curr. Opin. Cell Biol 4, 1008-1016.[Medline]

Farnsworth, C. C., Wolda, S. L., Gelb, M. H. and Glomset, J (1989). Human lamin B contains a farnesylated cysteine residue. J. Biol. Chem 264, 20442-20429.

Faust, J. and Krieger, M (1987). Expression of specific high capacity mevaonate transport in a Chinese hamster ovary cell variant. J. Biol. Chem 262, 1996-2004.[Abstract/Free Full Text]

Fisher, D. Z., Chaudhary, N. and Blobel, G (1986). cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc. Nat. Acad. Sci. USA 83, 6450-6454.[Abstract/Free Full Text]

Fukada, Y., Takao, T., Ohguro, H., Yoshizawa, T., Akino, T. and Shimonishi, Y (1990). Farnesylated-subunit of photoreceptor G protein indispensible for GTP-binding. Nature 346, 658-660.[Medline]

Goldman, A. E., Moir, R. D., Montag-Lowy, M., Stewart, M. and Goldman, R. D (1992). Pathway of incorporation of microinjected lamin A into the nuclear envelope. J. Cell Biol 119, 725-735.[Abstract/Free Full Text]

Hancock, J. F., Magee, A. I., Childs, J. E. and Marshall, C. J (1989). All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57, 11167-11177.

Hancock, J. F., Cadwallader, K. and Marshall, C. J (1991). Methylation and proteolysis are esential for efficient membrane binding of prenylated p21K-ras(B). EMBO J 10, 641-646.[Medline]

Inglese, J., Clickman, J. F., Lorenz, W., Caron, M. G. and Lefkowitz, R. J (1992). Isoprenylation of a protein kinase. J. Biol. Chem 267, 1422-1425.[Abstract/Free Full Text]

James, G. L., Goldstein, J. L., Brown, M. S., Rawson, T. E., Somers, T. C., McDowell, R. S., Crowley, C. W., Lucas, B. K., Levinson, A. D. andMarsters, J. C (1993). Benzodiazapine peptidomimetics: potent inhibitors of ras farnesylation in animal cells. Science 260, 1937-1942.[Abstract/Free Full Text]

Kim, C. M., Goldstein, J. L. and Brown, M. S (1992). cDNA cloning of MEV, a mutant protein that facilitates uptake of mevalonate and identification of the point mutation responsible for its gain of function. J. Biol. Chem 267, 23113-23121.[Abstract/Free Full Text]

Loewinger, L. and McKeon, F (1988). Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm. EMBO J 7, 2301-2309.[Medline]

Lutz, R. J., Trujillo, M. A., Denham, K. S., Wenger, L. and Sinensky, M (1992). Nucleoplasmic localization of prelamin A: Implications for prenylation-dependent lamin A assembly into the nuclear lamina. Proc. Nat. Acad. Sci. USA 89, 3000-3004.[Abstract/Free Full Text]

Ma, Y.-T. and Rando, R. R (1992). A microsomal endoprotease that specifically cleaves isoprenylated peptides. Proc. Nat. Acad. Sci. USA 89, 6275-6279.[Abstract/Free Full Text]

Marcus, S., Caldwell, G. A., Xu, C.-B., Naider, F. and Becker, J. M (1990). Total in vitro maturation of the Saccharomyces cerevisiae A-factor lipopeptide mating pheromone. Biochem. Biophys. Res. Commun 172, 1310-1316.[Medline]

Miyakawa, T. R., Miyama, M., Tabata, M., Tsuchiya, E. and Fukui, S (1985). A study of the biosynthesis of tremerogen A-10, a polyisoprenyl peptide mating pheromone of Tremella mesenterica , using an inhibitor of mevalonate synthesis. Agric. Biol. Chem 49, 1343-1374.

Omer, C. A., Kral, A., Diehl, R. E., Prendergast, G. C., Powers, S., Allen, C. A., Gibbs, J. B. and Kohl, N. E (1993). Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases. Biochemistry 32, 5167-5176.[Medline]

Reiss, Y., Goldstein, J. L., Seabra, M. C., Casey, P. J. and Brown, M. S (1991). Inhibition of purified p21rasfarnesyl-protein transferase by Cys-A-A-X tetrapeptides. Cell 62, 81-88.

Reiss, Y., Brown, M. S. and Goldstein, J. L (1992). Divalent cation and prenyl pyrophosphate specificities of the protein farnesyl transferase from rat brain, a zinc metalloenzyme. J. Biol. Chem 267, 6403-6408.[Abstract/Free Full Text]

Sarria, A. J., Nordeen, S. K. and Evans, R. M (1990). Regulated expression of vimentin cDNA in cells in the presence and absence of a prexisting vimentin filament network. J. Cell Biol 111, 553-565.[Abstract/Free Full Text]

Sinensky, M. and Lutz, R. J (1992). The prenylation of proteins. BioEssays 14, 25-31.[Medline]

Sobotka-Briner, C. and Chelsky, D (1992). COOH-terminal methylation of lamin B and inhibition of methylation by farnesylated peptides corresponding to lamin B and other CAAX motif proteins. J. Biol. Chem 267, 12116-12122.[Abstract/Free Full Text]

Southern, P. J. and Berg, P (1982). Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promotor. J. Mol. Appl. Genet 1, 327-341.[Medline]

Stephenson, R. C. and Clarke, S (1990). Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate. J. Biol. Chem 265, 16248-16254.[Abstract/Free Full Text]

Weber, K., Plessmann, U. and Traub, P (1989). Maturation of nuclear lamin A involves specific carboxy-terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina. FEBS Lett 257, 411-414.[Medline]

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				B. C. Capell, F. S. Collins, and E. G. Nabel Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes Circ. Res., July 6, 2007; 101(1): 13 - 26. [Abstract] [Full Text] [PDF]

				K. Cao, B. C. Capell, M. R. Erdos, K. Djabali, and F. S. Collins A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells PNAS, March 20, 2007; 104(12): 4949 - 4954. [Abstract] [Full Text] [PDF]

				T. Dechat, T. Shimi, S. A. Adam, A. E. Rusinol, D. A. Andres, H. P. Spielmann, M. S. Sinensky, and R. D. Goldman Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging PNAS, March 20, 2007; 104(12): 4955 - 4960. [Abstract] [Full Text] [PDF]

				Y. Liu, A. Rusinol, M. Sinensky, Y. Wang, and Y. Zou DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A J. Cell Sci., November 15, 2006; 119(22): 4644 - 4649. [Abstract] [Full Text] [PDF]

				A. E. Rusinol and M. S. Sinensky Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors. J. Cell Sci., August 15, 2006; 119(Pt 16): 3265 - 3272. [Abstract] [Full Text] [PDF]

				J. L. V. Broers, F. C. S. Ramaekers, G. Bonne, R. B. Yaou, and C. J. Hutchison Nuclear lamins: laminopathies and their role in premature ageing. Physiol Rev, July 1, 2006; 86(3): 967 - 1008. [Abstract] [Full Text] [PDF]

				R. L. Boguslavsky, C. L. Stewart, and H. J. Worman Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy Hum. Mol. Genet., February 15, 2006; 15(4): 653 - 663. [Abstract] [Full Text] [PDF]

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				K Fukuchi, T Katsuya, K Sugimoto, M Kuremura, H D Kim, L Li, and T Ogihara LMNA mutation in a 45 year old Japanese subject with Hutchinson-Gilford progeria syndrome J. Med. Genet., May 1, 2004; 41(5): e67 - e67. [Full Text] [PDF]

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				C. Vigouroux, M. Auclair, E. Dubosclard, M. Pouchelet, J. Capeau, J.-C. Courvalin, and B. Buendia Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene J. Cell Sci., March 14, 2002; 114(24): 4459 - 4468. [Abstract] [Full Text] [PDF]

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				C. K. L. Too, N. Vickaryous, R. T. M. Boudreau, and S. M. Sangster Identification and Nuclear Localization of a Novel Prolactin and Cytokine-Responsive Carboxypeptidase D Endocrinology, March 1, 2001; 142(3): 1357 - 1367. [Abstract] [Full Text] [PDF]

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				A. A. Adjei, C. Erlichman, J. N. Davis, D. L. Cutler, J. A. Sloan, R. S. Marks, L. J. Hanson, P. A. Svingen, P. Atherton, W. R. Bishop, et al. A Phase I Trial of the Farnesyl Transferase Inhibitor SCH66336: Evidence for Biological and Clinical Activity Cancer Res., April 1, 2000; 60(7): 1871 - 1877. [Abstract] [Full Text]

				O Klingenberg, A Wiedlocha, A Rapak, D Khnykin, L Citores, and S Olsnes Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus J. Cell Sci., January 5, 2000; 113(10): 1827 - 1838. [Abstract] [PDF]

				L. Citores, J. Wesche, E. Kolpakova, and S. Olsnes Uptake and Intracellular Transport of Acidic Fibroblast Growth Factor: Evidence for Free and Cytoskeleton-anchored Fibroblast Growth Factor Receptors Mol. Biol. Cell, November 1, 1999; 10(11): 3835 - 3848. [Abstract] [Full Text]

				R. M. Barton and H. J. Worman Prenylated Prelamin A Interacts with Narf, a Novel Nuclear Protein J. Biol. Chem., October 15, 1999; 274(42): 30008 - 30018. [Abstract] [Full Text] [PDF]

				J. Broers, B. Machiels, G. van Eys, H. Kuijpers, E. Manders, R van Driel, and F. Ramaekers Dynamics of the nuclear lamina as monitored by GFP-tagged A-type lamins J. Cell Sci., January 10, 1999; 112(20): 3463 - 3475. [Abstract] [PDF]