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Figure 7


Fig. 7. Model for site-specific MT1-MMP expression during neovessel formation. MT1-MMP-expressing endothelial tip cells are maintained in an immature state as they drive invasion and proliferation. By contrast, endothelial stalk cells assume a quiescent state as perivascular mural cells signal neighboring endothelial cells to suppress MT1-MMP expression and increase type IV collagen deposition.





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