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Figure 10


Fig. 10. Schematic representation of the effects the T19N and Q63L RhoB mutants have on CXCR2 trafficking. After 30 minutes of CXCL8 stimulation CXCR2 traffics to the Rab11a perinuclear recycling compartment and recycles back to the plasma membrane. CXCR2 traffics to the lysosome and is degraded after 3 hours of CXCL8 stimulation. Expression of T19N RhoB mutant results in constitutive recycling of CXCR2 through the Rab11a perinuclear recycling compartment after 3 hours of CXCL8 stimulation (blue arrows). Expression of the Q63L RhoB mutant results in the inability of CXCR2 to enter the Rab11a perinuclear recycling compartment after 30 minutes of CXCL8 stimulation and leads to CXCR2 recycling to the plasma membrane by alternative pathways (red arrows).





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