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Figure 7


Fig. 7. CRM1 localizes to CBs and is lost rapidly from them following treatment with LMB. In untreated HeLa cells, Crm1 (A) is found in CBs (arrows in A,B,D) where it colocalizes with snRNPs, detected with anti-Sm antibodies (B). Treatment of HeLa cells with LMB causes the loss of CRM1 from CBs (arrowheads in E,F,H). At timepoints up to 4 hours, snRNPs, detected by anti-Sm (F,H) or anti-TMG (J,L) antibodies, are still clearly seen in CBs (arrowheads and arrows). The CB marker protein, coilin, is also clearly seen in CBs after 4 hours of LMB treatment (I,L). Images A-H are deconvolved sections of HeLa cell nuclei; images I-L are three-dimensional projections of deconvolved serial sections of HeLa cell nuclei taken at 0.2 µm z-intervals. Bars, 13 µm.





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