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Figure 1


Fig. 1. GW bodies (GWBs) are heterogeneous structures with obvious differences in protein composition. (Top) HEp-2 cells stained with human anti-GWB serum (a prototype serum often used as a GWB marker and known to contain antibodies to GW182, hAgo2 and Ge-1, but not Dcp1; green) and rabbit anti-Dcp1 antibody (often used as a marker for P-bodies; red) demonstrate that not all GWBs contain Dcp1. (Bottom) HEp-2 cells stained with mouse anti-hAgo2 monoclonal (green) and rabbit anti-RCK/p54 (red) polyclonal antibodies demonstrate that not all foci containing RCK/p54 contain hAgo2. Conversely, not all foci that stain for hAgo2 contain RCK/p54. Arrows, GWBs that do not contain both protein factors. Arrowheads, GWBs that do contain both protein factors. Nuclei (blue) were counterstained with DAPI. Bar, 10 µm.





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