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First published online March 21, 2007

Journal of Cell Science 120, 704e (2007)
© The Company of Biologists Limited
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In this issue

Dawn arrival for condensin


Figure 1

During mitosis, interphase chromatin is reorganized into condensed, rigid chromosomes. This morphological change and the subsequent segregation of chromosomes requires the association of condensin I and II - protein complexes containing two ATPases of the structural maintenance of chromosomes (SMC) family and three non-SMC subunits - with the chromosomes. But what controls this? On p. 1245, Jan-Michael Peters and co-workers report that for condensin I (but not condensin II) the answer is Aurora B - a kinase that controls various stages of chromosome segregation. Using quantitative time-lapse imaging of human cells expressing GFP-labelled condensin subunits, the authors show that the loading of condensin I on to chromosomes in prometaphase and its maintenance on the chromosomes as mitosis proceeds requires Aurora B. The three non-SMC subunits of condensin I, they report, are phosphorylated by Aurora B in vitro and their phosphorylation during mitosis requires Aurora B. The authors conclude, therefore, that Aurora B contributes to chromosome rigidity and segregation during mitosis by promoting the binding of condensin I to chromatin.


Related articles in JCS:

Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes
Jesse J. Lipp, Toru Hirota, Ina Poser, and Jan-Michael Peters
JCS 2007 120: 1245-1255. [Abstract] [Full Text]  




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