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Figure 8


Fig. 8. ATP-{gamma}-S enhances epithelial wound closure in an EGFR-, HB-EGF-, ADAM10-, ADAM17-, ERK- and PI3K-dependent manner. Growth-factor-starved THCE cells were pretreated with the following inhibitors 1 µM AG 1478 (AG), 10 µg/ml CRM197 (CRM), 50 µM GM6001 (GM), 4 µM GW280264X (GW), 10 µM U0126 (U0) or 100 nM wortmannin (Wort) for 1 hour, wounded with a single tooth of a 48-well sharkstooth comb for DNA sequencing gels and allowed to heal in KBM containing 100 µM ATP-{gamma}-S in the presence of inhibitors. Wound closure was photographed immediately after wounding (0 h) or 6 hours p.w. (6 h). Micrographs in A represent one of three samples performed each time. Bar graph in B gives the statistical analysis of healing extent. Values are the mean ± s.e.m. (n=3), **P<0.01.





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