spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 10


Fig. 10. Proposed extracellular ATP involvement in corneal epithelial wound healing that summarizes the pathway from ATP release caused by cell injury to wound closure, including P2Y activation, intracellular Ca2+ release and EGFR signaling. Wounding results in the release of ATP from damaged cells, and the released ATP – through its P2 receptors – triggers intracellular Ca2+ waves leading to activation of ADAM protein(s) in a neighboring cell that is not injured ({triangleup}). ADAM protein(s) cleaves pro-HB-EGF at the cell surface and HB-EGF in an autocrine and/or paracrine fashion binds EGFR, which transduces the signals into the intracellular signaling network. After EGFR activation, HCE cell migration, proliferation and wound healing are induced via PI3K, ERK and other intracellular signaling pathways.





Right arrow Return to article