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Figure 9


Fig. 9. Increased tumor formation in Inv-Dsg2 transgenic mice. (A,B) Histological analysis of epidermal hyperplasia and early forms of papillomas in Inv-Dsg2 transgenic but not control wild-type mice at 6 weeks (A) and 3 months (B) (10x magnification). Arrows indicate hyperproliferation; box, hyperkeratosis; asterisk, encapsulated stratum corneum. (C) After 25 weeks of DMBA and TPA treatment, the Inv-Dsg2 transgenic mice developed more tumors than control wild-type mice. (D,E) The frequency and average number of papillomas in wild-type and transgenic mice after 25 weeks of tumor promotion. For tumors greater than 2 mm, *P=0.0063. (F) Histopathological appearance of carcinogen-induced tumors from wild-type and transgenic mice showing differentiated and hyperkeratotic papillomas.





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