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Figure 5


Fig. 5. Activated Src distribution in tau-transfected 3T3 cells following PDGF stimulation. 3T3 cells were transfected with tau, stimulated with PDGF, and double-labeled with anti-Src (phospho-Y416) (A-F) and anti-tau (G-I). Quiescent cells showed activated Src located in focal adhesions (Fincham and Frame, 1998) (A,D). Upon stimulation with PDGF, activated Src localized to the periphery in a punctate pattern (B,E). At 7 hours, while the Src distribution reverted to the focal adhesions in non-transfected cells (C), in tau-expressing cells, much activated Src was still localized at the periphery (F). The tau distribution (G-I) was non-fibrillar owing to the fixation conditions required for labeling with the activated Src antibody. Bar, 10 µm.





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