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Fig. 1. LINT-25 is a novel interaction partner of LAP2 ${alpha}$ . (A) Diagram of the domain organization of LAP2 ${alpha}$ , full-length human OIP5/LINT-25 (229 residues, TIGR THC2238209) and the yeast two-hybrid fragment identified using LAP2 ${alpha}$ -specific C-terminus as bait. The light gray box in human LINT-25 (residues 75-219) delineates conserved regions found also in protein sequences in Mus musculus (TIGR TC1500192), Rattus norvegicus (GB XM_575214), Gallus gallus (GB XM_421136), Xenopus laevis (TIGR TC267260), Danio rerio (TIGR TC296675) and Homo sapiens (TIGR THC2246127) with dotted lines showing the predicted full-length proteins. The black rectangle represents a predicted coiled-coil domain. Accession numbers given are from the Institute for Genomic Research (TIGR) and from GenBank (GB). The two numbers below each bar indicate the percentage identity and similarity, respectively, to human LINT-25 protein sequence. (B) RT-PCR analyses of LINT-25, LAP2 ${alpha}$ , and actin mRNA as control, using mRNAs from the indicated human tissues or cell line: bone marrow (Bm), brain (B), colon (C), heart (H), kidney (K), skeletal muscle (Sk), thymus (Th), testis (T) and uterus (U). An ethidium bromide-stained gel of PCR fragments is shown.

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