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Figure 2


Fig. 2. G-quartet (G) formation on the lagging telomeric DNA is normally resolved by WRN (orange box), enabling efficient replication of lagging strand G-rich telomeres. In the absence of WRN, G-quartet formation on the lagging telomere leads to replication fork stalling and deletion of lagging-strand telomeres (Crabbe et al., 2004). The resultant dysfunctional telomeres can initiate a p53-dependent DNA-damage response, leading to premature onset of replicative senescence.





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