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Figure 1


Fig. 1. (A) Telosome/shelterin complex and telomere structure. The telomere folds back onto itself to form a double-stranded t-loop and a single-stranded D-loop. This complex protects telomeres at the G2 phase of the cell cycle from inappropriate NHEJ- and HR-mediated processing of telomeric DNA. The six-component telosome/shelterin is shown schematically on the t-loop, with POT1 interacting with the D-loop. (B) During DNA replication, the presence of WRN at the replication fork is postulated to enable the replication complex to efficiently replicate telomeric DNA. (C) The presence of WRN at telomeres may facilitate unwinding of the D-loop, enabling telomerase to extend telomeres. The linear 3' overhang is probably protected by POT1.





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