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Figure 4


Fig. 4. IQGAP1-dependent recruitment of N-WASP, Arp3 and FGFR1 to the cell periphery after FGF2 stimulation. Immunofluorescence microscopy revealed co-recruitment and colocalization of IQGAP1, N-WASP, Arp3 and FGFR1 to lamellipodia after FGF2 stimulation for 10 minutes, of low-density cultures of serum-starved MDBK cells containing IQGAP1 (Control cells). FGF2 was unable to recruit N-WASP, Arp3 and FGFR1 to cell margins in IQGAP1-deficient, siRNA-treated cells. To improve visualization of cell margins and intracellular details in IQGAP1-depleted cells, micrograph exposures for the siRNA samples were twice as long in the TRITC channel and 4.5 times longer in the FITC channel as they were for the scrRNA samples.





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