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Figure 4


Fig. 4. Effect of OST subunit knockdown on the N-glycosylation of type II membrane proteins. Transmembrane topology and number of N-linked glycans (branched structures) for the two proteins studied. (A) Human invariant chain was synthesised as previously described to determine the extent of its N-glycosylation (see Fig. 3A). The resulting glycosylated (+ 2CHO) and non-glycosylated (– CHO) polypeptides are shown with the proportion of N-glycosylated products calculated as before (see Fig. 3A), and symbols are as previously described. (B) Human asialoglycoprotein receptor (ASGPR) was synthesised and products analysed as in A. The numbers below the lanes are the mean ± s.e.m. of three independent experiments. Levels of N-glycosylation that differ from the mock-treated control by a significance of at least 0.02 are indicated (*).





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