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Fig. 5. Expression of Epb41l3, encoding 4.1B protein, in the sarcoma cells. (A) Normalised expression levels of the Epb41l3 gene are shown for the cultured cells and the primary tumours. The normalisation was based on median values from individual microarrays. Each dot and bar represents the mean value ± s.e.m. of the expression levels obtained from multiple microarrays. Epb41l3 is significantly downregulated in the metastatic cells (P<0.05), and this expression pattern is closely matched by that of the tumours. (B) The difference in expression also occurs at the protein level, as seen in this western blot, in which very little 4.1B is detectable in cultured T15, A297 and A311 cells. Actin was used as a loading control.
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