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Fig. 3. Immunisation has no effect on tPA-independent behaviour tasks. (A,B) Spontaneous locomotor activity in an activity cage. No difference was seen in either group. (C,D) Mice were subjected to an elevated plus-maze, which allows the measurement of the anxiety level. (C) The activity of tPA-deficient mice in the closed or open arms of the maze did not differ from that of WT mice. (D) Accordingly no behaviour difference was seen in the plus-maze between control, CFA-treated and NTD-NR1-vaccinated mice.