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First published online December 5, 2007

Journal of Cell Science 120, 2404e (2007)
© The Company of Biologists Limited
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In this issue

The trials of centrosome separation


Figure 1

Centrosome duplication is necessary for cell division. This occurs at S phase, but the new centrosomes do not split from each other until prophase. What holds them together after duplication, until they separate to enable mitotic spindle formation? A proteinaceous linker is thought to maintain this association, but details of its makeup remain unclear. On page 4321 of this issue, Erich Nigg and co-workers identify two new components in the linker: Cep68 and Cep215. In an RNAi screen of 38 putative centrosomal proteins, they find that knocking down of Cep68 and Cep215, and three previously identified candidates, abolishes centrosome cohesion. Immunogold electron microscopy shows that both proteins lie adjacent to centrioles. The authors use further RNAi studies to show that Cep68 and other proteins, such rootletin, have interdependent roles in centrosome cohesion. Their work yields a clearer picture of the mechanisms of centrosomal duplication and splitting, suggesting a key role for Cep68 in forming the proteinaceous linker, and an accessory function for Cep215.


Related articles in JCS:

Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion
Susanne Graser, York-Dieter Stierhof, and Erich A. Nigg
JCS 2007 120: 4321-4331. [Abstract] [Full Text]  




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