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First published online December 5, 2007

Journal of Cell Science 120, 2403e (2007)
© The Company of Biologists Limited
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In this issue

Myosin VI: an ERCsome motor


Figure 1

Myosin VI is unique among myosin motors because it travels `backwards' (towards the minus end) along actin filaments. Perhaps because of this unusual property, myosin VI plays a role in diverse membrane trafficking processes, including early endocytosis and exocytic trafficking from the Golgi. On page 4278, Folma Buss and colleagues identify a new role for myosin VI in the delivery of cargo from early endosomes to the endosomal recycling compartment (ERC), as well as a new myosin-VI-binding partner, LMTK2, that acts in the same pathway. The authors have mapped the interacting regions of myosin VI and LMTK2 by using yeast and mammalian two-hybrid screens and co-immunoprecipitation. Moreover, they show that the two proteins colocalise. Importantly, knocking down either myosin VI or LMTK2 by RNAi leads to swollen early endosomes and impedes the normal transfer of transferrin from early endosomes to the ERC, demonstrating a role for both proteins in endosomal recycling.


Related articles in JCS:

Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment
Margarita V. Chibalina, Matthew N. J. Seaman, Christopher C. Miller, John Kendrick-Jones, and Folma Buss
JCS 2007 120: 4278-4288. [Abstract] [Full Text]  




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