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First published online December 5, 2007

Journal of Cell Science 120, 2401e (2007)
© The Company of Biologists Limited
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In this issue

Cytokinesis: the MiDAS touch


Figure 1

Dictyostelium form a myosin-containing contractile ring to divide daughter cells during mitosis. Mutants that lack myosin motors do not undergo mitosis in suspension, but can still divide if attached to a substrate. Although substratum attachment is thought to allow daughter cells to generate traction force for pushing away from one another, the way in which force might be exerted remains obscure. Go Itoh and Shigehiko Yumura (p. 4302) now describe the formation of novel actin structures (termed MiDASes) during mitosis in myosin-null and wild-type Dictyostelium, which might help generate traction. Using total internal reflection fluorescence (TIRF) microscopy of GFP-actin, they show that MiDASes localise to the ventral surface of the cell, under the nucleus, and migrate with daughter nuclei. Importantly, MiDASes are points for attachment of cells to the substrate, implying that they can generate traction for the cell. The authors demonstrate that MiDAS formation may play a role in forcing daughter cells apart.


Related articles in JCS:

A novel mitosis-specific dynamic actin structure in Dictyostelium cells
Go Itoh and Shigehiko Yumura
JCS 2007 120: 4302-4309. [Abstract] [Full Text]  




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