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Figure 2


Fig. 2. Spatial mechanisms governing proteolysis of CtrA. (A) The master regulator and inhibitor of DNA replication initiation, CtrA, transiently localizes (red) at the incipient stalked pole at the swarmer (SW) to stalked (ST) cell transition and at the ST pole upon compartmentalization of the cytoplasm in predivisional cells. It localizes there with the protease ClpXP (green), the degradation factor RcdA (orange) and the response regulator CpdR (blue) (in its unphosphorylated state), and is thereby targeted for proteolysis by ClpXP. This relieves the CtrA-mediated block on DNA replication initiation. The cell cycle-regulated phosphorylation state of CpdR is indicated. (B) The hierarchical dependency of ST pole localization for factors necessary for CtrA clearance. Unphosphorylated CpdR at the ST pole is required for polar localization of ClpXP, which is required for the localization of RcdA, which is required for the localization of CtrA.





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