spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online January 10, 2007

Journal of Cell Science 120, 205e (2007)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Lamp light for neuronal endosomes


Figure 1

LAMP proteins are involved in lysosomal function and intracellular trafficking. During a bioinformatics-based search for lysosome-associated molecules, Philippe Pierre and co-workers have identified brain-associated LAMP-like molecule (BAD-LAMP), a new member of the LAMP family in mice (p. 353). This unconventional LAMP-like protein defines a new endocytic compartment in specific subsets of cortical projection neurons. Interestingly, its post-natal expression coincides with cortical synaptogenesis, indicating a possible role in this process. Unlike other LAMP family members, BAD-LAMP has a highly restricted localisation: it is enriched in distinct intracellular vesicles in defined zones along the neuronal projections. Although BAD-LAMP is endocytosed, the vesicles in which it accumulates do not contain markers for classical intracellular transport pathways. Further analysis of BAD-LAMP endocytosis in HeLa cells revealed that it constantly recycles to the plasma membrane via a dynamin/AP2-dependent mechanism. The defined expression and distribution patterns of BAD-LAMP demonstrate a role for non-conventional endocytic vesicles and membrane lipids in the maturation or function of specific cortical neurones.


Related articles in JCS:

BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons
Alexandre David, Marie-Catherine Tiveron, Axel Defays, Christophe Beclin, Voahirana Camosseto, Evelina Gatti, Harold Cremer, and Philippe Pierre
JCS 2007 120: 353-365. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content