spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 6


Fig. 6. The CUL-3MEL-26 ubiquitin ligase might target two distinct AAA-ATPases for degradation at different developmental stages. The CUL-3MEL-26 complex degrades FIGL-1 during meiotic stages in the gonad. By contrast, FIGL-1 is largely protected from degradation in the mitotic zone, possibly because of spatial restriction of MEL-26. At the meiosis-to-mitosis transition, the same E3 ligase targets MEI-1 for degradation (Pintard et al., 2003b). The different timing of degradation of FIGL-1 and MEI-1 might be regulated by phosphorylation by means of kinases present at these different developmental stages.





Right arrow Return to article