spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online August 22, 2007

Journal of Cell Science 120, 1705e (2007)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

GAPs in Golgi formation


Figure 1

Rab GTPases control transport between the ER and the Golgi complex and, consequently, are important for maintenance of the Golgi. GTPase-activating proteins (GAPs) inactivate GTP-bound Rab proteins; so to discover which human Rab proteins are needed to maintain an active Golgi complex, Francis Barr and colleagues have screened a host of human Rab GAPs for the ability to disrupt the Golgi and ER-to-Golgi protein transport in human cells (see p. 2997). They find that only two GAPS (RN-tre and TBC1D20, GAPS for Rab43 and Rab1, respectively) disrupt both these processes. TBC1D20, the authors show, is localised to the ER by a transmembrane anchor and its overexpression blocks ER-to-Golgi transport and causes loss of the Golgi. Knocking down Rab1 by RNAi produces a similar phenotype, they report, whereas expression of the TBC1D20-binding partner reticulon antagonises the effects of TBC1D20 overexpression. The authors therefore conclude that Rab1 and Rab43 are required for the biogenesis and maintenance of human Golgi complexes.


Related articles in JCS:

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells
Alexander K. Haas, Shin-ichiro Yoshimura, David J. Stephens, Christian Preisinger, Evelyn Fuchs, and Francis A. Barr
JCS 2007 120: 2997-3010. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content