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Figure 4


Fig. 4. APC inhibits MyoD expression: Microtubule-association of APC is not essential. (A) APC inhibits MyoD expression: Confocal analysis of cells transfected with full-length APC (APC-FL-GFP) or APC lacking the microtubule-binding domain (APC{Delta}MT-GFP). Full-length APC is microtubule associated whereas APC{Delta}MT-GFP localizes to the cytoplasm; both forms effectively inhibit MyoD expression (red). Bar, 20 µm. (B) Quantification of MyoD expression in cells transfected with GFP alone (control) APC-FL-GFP or APC{Delta}MT-GFP (mean ± s.e.m., n=2).





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