spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online July 2, 2007

Journal of Cell Science 120, 1403e (2007)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Adapters actin' together


Figure 1

Adapter proteins help to control various aspects of cellular behaviour by mediating protein–protein interactions. Now, Kathrin Kirsch and colleagues report that two closely related adapter proteins – CMS and CIN85 – modulate dynamic rearrangements of the actin cytoskeleton (see p. 2366). Both proteins contain three N-terminal Src homology 3 (SH3) domains, a proline-rich region (PR), a linker region and a C-terminal coiled-coil (CC) domain that mediates oligomerization. The authors first show that CMS is a component of podosomes (actin-rich adhesion structures) and that its entire C-terminal half is required for efficient binding to filamentous actin. They then demonstrate that CMS and CIN85 both crosslink actin to form bundles; this activity depends on their PR and CC domains and is needed for cell migration. Finally, they show that CMS and CIN85 interact through their CC domains to form heterodimers. Because CIN85 exists as different isoforms, all of which contain the CC domain, the authors propose that heterotypic interactions between these isoforms and CMS regulate its binding to actin and thus modulate cytoskeletal rearrangements.


Related articles in JCS:

Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation
Gabriel Gaidos, Shefali Soni, Duane J. Oswald, Paul A. Toselli, and Kathrin H. Kirsch
JCS 2007 120: 2366-2377. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content