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Figure 4


Fig. 4. Sca-1-mediated signaling activates Akt to support CSC proliferation and survival. (A) Representative photographs of TUNEL assay obtained from NTG- or Sca-1 KD-derived CSCs treated with 200 µM H2O2 for 18 hours. The numbers of apoptotic cells (brown nuclei) in NTG (C6)- or Sca-1 KD-CSCs (C1) are shown (n=8). *P<0.01 versus NTG. (B) Loss of Sca-1 diminished EGF and bFGF-induced Akt activation in CSCs. CSCs treated with 200 µm H2O2 for 15 minutes were used as positive controls. Bars, 50 µm in A.





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