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Figure 7


Fig. 7. PI3K-dependent signalling is required at multiple stages of developmental haemopoiesis. Our studies have demonstrated that PI3K signalling is required for proliferation of cells within the developing EB at the early stages of development. However, inhibition of PI3K/PDK1-mediated signals does not block differentiation towards the BL-CFC, as indicated by Flk-1 and brachurury expression and blast colony formation. A crucial requirement for PI3Ks and PDK1 was defined during the expansion of the BL-CFC to form blast colonies and this appears to be mainly at the level of proliferation. Inhibition of PI3Ks only during the HCAs indicates PI3Ks are required for optimal generation of myeloid lineages and optimal proliferation of erythroid cells.





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