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Figure 6


Fig. 6. Injection of recombinant active neuropsin into NP-/- mice restores L1ir synapses to NP+/+ levels. (A) Fluorescent microscopic photograph represent spread of recombinant actneuropsin in the hippocampus. Injection of FITC-conjugated recombinant actneuropsin reaches the observation site of the stratum radiatum. (B) Number (left) and percentage (right) of L1ir synapses one day after injection of ACSF or active neuropsin (act NP) into NP-/- mice. The number and percentage of L1ir synapses were significantly decreased (actNP, closed bars; *P<0.05) to the levels in untreated wild-type mice (untreated, open bars). There was no significant difference between the treated NP-/- mice and untreated wild-type mice (number, P>0.24; percentage, P>0.08). **P<0.001.





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