QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

	Help viewing high resolution images
	Return to article

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.

Fig. 3. Shift from smaller to larger L1ir synapses in NP^-/- mice. (A) The stratum radiatum was divided into three regions, proximal (prox.), middle (mid.) and distal (dist.), according to distance from the CA1 soma. In NP^+/+ mice (open bars), the mean cross-sectional spine head area of L1ir (L1) synapses is significantly smaller than that of L1ir-negative (L1neg) synapses in all regions of the stratum radiatum. The mean spine head area of L1ir synapses is larger in NP^-/- mice (filled bars) than in NP^+/+ mice (open bars), especially in the proximal region. ^*P<0.05; ^**P<0.001. (B) The distribution of spine head area in the proximal region of L1ir synapses and L1ir-negative synapses in NP^+/+ and NP^-/- mice. In NP^+/+ mice, L1ir synapses were significantly smaller than L1ir-negative synapses (Kolmogorov-Smirnov test, P<0.03). In NP^-/- mice, the distribution of L1ir synapses shifted to a larger size, comparable with that of L1ir-negative synapses. (C) The mean cross-sectional PSD length of L1ir synapses was significantly smaller than that of L1ir-negative synapses in NP^+/+ (open) and NP^-/- (closed) mice, except in the proximal region where the length of L1ir synapses in NP^-/- mice was significantly larger than that in NP^+/+ mice and comparable with the level in L1ir-negative synapses (P>0.55). ^*P<0.05; ^**P<0.001.

Return to article