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Figure 5


Fig. 5. A model for the regulation of MRFs and TCF/LEF-1 by ß-catenin and I-mfa in myogenesis. In the absence of a canonical Wnt signal, I-mfa suppresses transcriptional activities of MRF and TCF/LEF-1 by binding to them. In the presence of canonical Wnt proteins, canonical Wnt signaling is activated, and the levels of ß-catenin increase in the cytoplasm and nucleus are elevated. ß-catenin then binds to I-mfa and relieves I-mfa suppression of TCF/LEF-1 and MRF, which is required for myogenic specification and development.





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