p63 is upstream of IKK in epidermal development

JCS03265 Supplementary Material

Files in this Data Supplement:

• Supplemental Table 1 -

  Adobe PDF

• Supplemental Figure 1 -

  Fig. S1. Analysis of human IKKα promoter region. Map of selected transcription factors binding sites found in IKKα proximal promoter. The transcription factors more relevant during skin development and differentiation are shown. Each transcription factor is represented by a different color. Details related to core and matrix similarity are shown in Supplementary Table S1.

• Supplemental Figure 2 -

  Fig. S2. Histology of p63^−/− knockout mice. Histologically, only very rare skin patches are present in the outer part of tissues taken from 19.5-day embryos. Complementation of p63^−/− mice with ΔNp63α (p63^−/−;ΔN), allows a degree of epidermal development. The reintroduction of both ΔNp63α and TAp63α into the p63^−/− background (p63^−/−;ΔN;TA) results in a more extensive reconstruction of the basal layer in several skin areas as observed in the sections stained for K14 (red) and p63 (green). Bar, 100 μm.